在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KCNK4 Antibody

KCNK4 Antibody

  • 中文名稱：
    KCNK4兔多克隆抗體
  • 貨號：
    CSB-PA004321
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of HT29 cells using TRAAK Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KCNK4
  • 別名：
    KCNK4; TRAAK; Potassium channel subfamily K member 4; TWIK-related arachidonic acid-stimulated potassium channel protein; Two pore potassium channel KT4.1; Two pore K(+ channel KT4.1
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human TRAAK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Voltage-insensitive potassium channel. Channel opening is triggered by mechanical forces that deform the membrane. Channel opening is triggered by raising the intracellular pH to basic levels. The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius. Plays a role in the perception of pain caused by heat. Plays a role in the sensory perception of pain caused by pressure.
  • 基因功能參考文獻：
    1. Functional alanine-mutagenesis screens of TASK-1 and TRAAK were used to build an in silico model of the TASK-1 cap. PMID: 26794006
    2. KCNK4 promoter methylation is associated with Breast Cancer. PMID: 25809865
    3. How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2. PMID: 26332952
    4. findings uncover a unique aspect of potassium channel modulation, indicate a means for how the channel C-terminal cytoplasmic domain affects the C-type gate, and suggest how lipids and bilayer inner leaflet deformations gate the channel. PMID: 25500157
    5. TRAAK is responsive to mechanical forces similar to the ion channel Piezo1; mechanical activation of TRAAK can electrically counter Piezo1 activation. PMID: 24550493
    6. structure reveals a domain-swapped chain connectivity enabled by the helical cap that exchanges two opposing outer helices 180 degrees around the channel PMID: 23341632
    7. crystal structure of TRAAK at 3.8 angstroms resolution; channel comprises 2 protomers that create 2-fold symmetric K(+) channel; extracellular surface has a helical cap; 2 diagonally opposed gate-forming inner helices form membrane-interacting structures PMID: 22282805
    8. role for TREK-1 in contributing to uterine quiescence during gestation PMID: 20811500
    9. Human TASK-3 was cloned and expressed; protein sequence and activity compared to similar two pore domain potassium channels, including KCNK4 (TRAAK). PMID: 11042359

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Two pore domain potassium channel (TC 1.A.1.8) family
  • 數據庫鏈接：

    HGNC: 6279

    OMIM: 605720

    KEGG: hsa:50801

    STRING: 9606.ENSP00000378033

    UniGene: Hs.647233



主站蜘蛛池模板： 欧美大片aaaaa免费观看| 欧美videos另类极品| 国产成人亚洲无吗淙合青草| 少妇的渴望hd高清在线播放| 日本真人做爰免费视频120秒| 欧美日韩精品一区二区视频| 久久亚洲精品成人av二次元| 亚洲综合激情五月丁香六月| 99精品国产成人一区二区| 国精品无码一区二区三区在线蜜臀| 永久免费男同av无码入口| 波多野成人无码精品电影| 日本少妇毛茸茸高潮| 精品无人区一区二区三区 | 欧美日本免费一区二区三区| 亚洲成在人线视av| 曰韩欧美群交p片内射| 两个男人吮她的花蒂和奶水视频| 无码熟妇人妻av在线电影| 中文字幕欧美人妻精品一区| 国产aⅴ爽av久久久久久| 久久天天躁狠狠躁夜夜2019| 狠狠躁夜夜躁av网站中文字幕| 大陆熟妇丰满多毛xxxⅹ| 日本熟妇色一本在线视频| 国产亚洲精品成人aa片新蒲金 | 国产精品福利自产拍久久| 国产又色又爽无遮挡免费动态图| 一边啪啪的一边呻吟声口述| 韩国主播av福利一区二区| av在线播放日韩亚洲欧| 欧美尺码专线欧洲b1b1| 人妻激情乱人伦| 日韩精品一区二区三区| 亚洲一区二区女搞男| 中文字幕久久精品一区二区三区| 熟妇人妻av中文字幕老熟妇| 国产成人亚洲综合色婷婷| 国产精品久久久久久无码五月| 爱久久av一区二区三区| 日韩一区二区三区无码影院 |