在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KCNJ3 Antibody, FITC conjugated

  • 中文名稱:
    KCNJ3兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA012056LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KCNJ3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    KCNJ3; GIRK1; G protein-activated inward rectifier potassium channel 1; GIRK-1; Inward rectifier K(+ channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human G protein-activated inward rectifier potassium channel 1 protein (350-487AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat.
  • 基因功能參考文獻:
    1. these data suggest that patients with estrogen receptor positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor PMID: 27835900
    2. Results clearly corroborate that overexpression of GIRK1 protein exerts profound effects on wound healing, chemoinvasion and cellular motility in the MCF-7 breast cancer cell line suggesting a role to promote invasion and metastasis. PMID: 27519272
    3. GIRK1/GIRK4 hetero-tetramers are not activated by Na+, but rather are in a permanent state of high responsiveness to G proteins beta-gamma, suggesting that the GIRK1 subunit functions like a GIRK4 subunit with Na+ permanently bound. PMID: 27074664
    4. The findings of this study suggest that variations in KCNJ3 genes are associated with both mild and severe persistent breast pain after breast cancer surgery. PMID: 25599232
    5. For KCNJ3 rs7574878, individuals who were heterozygous or homozygous for the rare G allele (TT versus TG+ GG) had a 48% reduction in the odds of reporting preoperative breast pain. PMID: 24392765
    6. we show that Kir3.1, in the absence of trafficking partner subunits, can exit the endoplasmic reticulum (ER) and reach the Golgi (though not the plasma membrane) PMID: 23368630
    7. In the dorsal horn of the developing rat, K(ir)3.1 and K(ir)3.2 were expressed at mature levels from birth. PMID: 23219908
    8. Conformational changes at the Gbetagamma/Kir3 interface were lost when Kir3.1 subunits were replaced. PMID: 23175530
    9. These data suggest that the KCNJ3 gene is genetically associated with schizophrenia in Asian populations and add further evidence to the "channelopathy theory of psychiatric illnesses". PMID: 21927946
    10. Kir3.1 channel is involved in the TLR4-mediated signal at an early event by facilitating the recruitment of TLR4 into lipid raft. PMID: 21420934
    11. halothane predominantly interferes with Gbetagamma-mediated Kir3 currents, such as those functioning during inhibitory synaptic activity PMID: 21044958
    12. The very high abundance of mRNA's encoding GIRK1 together with the presence of GIRK1 protein suggests a pathophysiological role in breast cancer PMID: 20512921
    13. We identified several known single nucleotide polymorphisms in KCNJ3 and KCNJ5, but no mutations in either of the genes. PMID: 20110696
    14. glutamate residue at the C terminus regulates activity -- implications for Andersen Disease (inward rectifier potassium channel 2; IRK2) PMID: 12034888
    15. that GIRK channels are important functional effectors of the P2Y(12) receptor in human platelets. PMID: 15142872
    16. GIRK1 and GIRK2 channels, but not GIRK3 or GIRK4, may may activate signaling pathways in development of lung cancer PMID: 16109170
    17. GIRK1 was overexpressed in breast carcinoma suggesting its involvement in proliferation and oncogenesis and its possible use as a putative pharmaceutical target. PMID: 18498071
    18. Sar 1 H79G and Rab 1 S25N mutants efficiently blocked the plasma membrane trafficking of the Kir3.1/Kir3.4 complex however they did not block the Gbeta1gamma2/Kir3.1 interaction. Gbeta1-4 can interact with Kir3.1 in the absence of Kir3.4. PMID: 19135528
    19. S385 identified as in vitro phosphorylation site. Mutation of this residue to alanine resulted in reduced sensitivity of Kir3.1* currents to H89 & Forskolin, confirming in vivo role for this novel site of the Kir3.1 channel subunit in regulation by PKA. PMID: 19151997

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ3 subfamily
  • 數據庫鏈接:

    HGNC: 6264

    OMIM: 601534

    KEGG: hsa:3760

    STRING: 9606.ENSP00000295101

    UniGene: Hs.591606



主站蜘蛛池模板: 亚洲无线码一区二区三区| 久久久免费精品re6| 又黄又爽又高潮免费毛片| 国产精品久久人妻无码网站蜜臀| 亚洲第一无码av无码专区| 亚洲精品nv久久久久久久久久| 免费人成视频在线| 免费国产白丝喷水娇喘视频| 亚洲国产成人久久综合碰碰| 性色av无码不卡中文字幕| 亚洲成在人线av| 无码国产激情在线观看| 久久天天躁狠狠躁夜夜96流白浆| 6699嫩草久久久精品影院| 97国产精东麻豆人妻电影| 久久天堂av综合合色蜜桃网| 国产精品天天看特色大片| 免费看成人aa片无码视频羞羞网 | 日本欧美久久久久免费播放网| 热99re久久精品国产首页免费| 国语自产精品视频在线第100页| 欧美性猛交xxxxx按摩欧美 | 私人家庭影院5777| 欧美人与动另类xxxx| 国色天香成人网| 亚洲中文欧美在线视频| 欧美成人精品一区二区三区色欲| 成人天堂婷婷青青视频在线观看| 不卡无码av一区二区三区| 人人澡人人澡人人看添| 色综合久久网| yy111111少妇无码理论片| 天干天干夜啦天干天干国产| 中文字幕中文乱码www| 97久久国产亚洲精品超碰热| 久久 国产 尿 小便 嘘嘘| 亚洲伦无码中文字幕另类| 情人伊人久久综合亚洲| 久久精品国产99久久丝袜蜜桃| 高潮好爽视频在线观看| 99久热re在线精品99 6热视频|