在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KCNJ12 Antibody, HRP conjugated

KCNJ12 Antibody, HRP conjugated

  • 中文名稱：
    KCNJ12兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA619877LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KCNJ12 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNJ12
  • 別名：
    KCNJ12; IRK2; KCNJN1; ATP-sensitive inward rectifier potassium channel 12; Inward rectifier K(+ channel Kir2.2; IRK-2; Inward rectifier K(+ channel Kir2.2v; Potassium channel, inwardly rectifying subfamily J member 12
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human ATP-sensitive inward rectifier potassium channel 12 protein (182-433aa)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Inward rectifying potassium channel that is activated by phosphatidylinositol 4,5-bisphosphate and that probably participates in controlling the resting membrane potential in electrically excitable cells. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
  • 基因功能參考文獻：
    1. Cellular electrophysiology assays of mouse Kir2.1 and human Kir2.2 indicated that, consistent with simulations, the Leu residue increased the channel responses to phosphatidylinositol diphosphate (PIP2) through increased binding affinity and faster activation kinetics, and the deactivation kinetics decreased upon PIP2 inhibition. PMID: 26520451
    2. This report is the first to describe the KCNJ12 gene as a cause of familial dilated cardiomyopathy in patients PMID: 28816949
    3. The augmentation of Ca(2+) influx and cytokine release suggests a physiological role for Kir2.2 in TLR4-stimulated monocytes. PMID: 26324774
    4. Unconventional role of the inwardly rectifying potassium channel Kir2.2 as a constitutive activator of RelA in cancer. PMID: 23269273
    5. Kir2.2 knockdown induces senescence of cancer cells by a mechanism involving reactive oxygen species accumulation. PMID: 20841375
    6. heteromerization contributes to the phenotype of Andersen syndrome PMID: 12032359
    7. Molecular cloning of functional KCNJ12 with an arginine residue at position 285. PMID: 12417321
    8. transcripts for Kir2.2 potassium channels are identified in proliferative smooth muscle cells PMID: 12598232
    9. Data show that the recovery of K(ir)2.2 from inhibition by FCCP requires intracellular components, but direct depletion of ATP does not reproduce the differential inhibitory effect of FCCP. PMID: 19016473

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Inward rectifier-type potassium channel (TC 1.A.2.1) family, KCNJ12 subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6258

    OMIM: 602323

    KEGG: hsa:3768

    STRING: 9606.ENSP00000328150

    UniGene: Hs.200629



主站蜘蛛池模板： 国产欧美精品一区二区三区四区| 亚洲精品国精品久久99热| 色妺妺av爽爽影院| 人人玩人人添人人澡欧美| 囯产精品一区二区三区线| 欧美顶级少妇作爱| 国产嫖妓风韵犹存对白| 扒开双腿猛进入喷水高潮叫声| 精品国产卡一卡2卡3卡| 香港aa三级久久三级| 我和亲妺妺乱的性视频| 美女张开腿让人桶| 无遮挡激情视频国产在线观看| 国产超碰人人做人人爽av大片| 在线视频观看免费视频18| 18禁肉肉无遮挡无码网站 | 永久免费观看美女裸体的网站 | 久久久国产成人一区二区| 奇米777狠狠色噜噜狠狠狠| 免费无码肉片在线观看| 国产亚洲精品久久久久久无几年桃 | 精品人妻系列无码人妻免费视频| 大香伊蕉在人线免费视频| 成人免费无码大片a毛片小说 | 久久国产色av免费观看 | 色五月五月丁香亚洲综合网| 尹人香蕉久久99天天拍欧美p7| 久久www色情成人免费观看| 麻豆av一区二区三区| 乱中年女人伦av| 国产高清视频色拍| 欧美婷婷六月丁香综合色| 精品国产av无码一区二区三区| 亚洲欧美日韩在线码| 国产大量精品视频网站| 开心五月激情综合婷婷色| 刺激一区仑乱| 又色又爽又高潮免费观看| 人妻少妇无码中文幕久久| 久久精品国产99国产精品| 图片区小说区激情区偷拍区|