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  4. KCNIP4 Antibody, Biotin conjugated

KCNIP4 Antibody, Biotin conjugated

  • 中文名稱：
    KCNIP4兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA750882LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KCNIP4 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCNIP4
  • 別名：
    A type potassium channel modulatory protein 4 antibody; A-type potassium channel modulatory protein 4 antibody; CALP antibody; Calsenilin like protein antibody; Calsenilin-like protein antibody; HGNC:30083 antibody; KCHIP 4 antibody; KChIP4 antibody; KCIP4_HUMAN antibody; KCNIP 4 antibody; Kcnip4 antibody; Kv channel interacting protein 4 antibody; Kv channel-interacting protein 4 antibody; MGC44947 antibody; Potassium channel interacting protein 4 antibody; Potassium channel-interacting protein 4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Kv channel-interacting protein 4 protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
  • 基因功能參考文獻：
    1. Results indicate that SNPs in KCNIP4 may modulate ACE inhibitor-induced cough risk. PMID: 26169577
    2. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4. PMID: 24811166
    3. genetic association studies in populations in Germany: Data suggest that multiple SNPs in KCNIP4 are associated not only with attention deficit disorder with hyperactivity in children and adults but also with personality disorders. PMID: 22981920
    4. Genome-wide association study identifies KCNIP4 as an asthma gene in human and in mouse. PMID: 23457522
    5. KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID: 23576435
    6. The synthesis of the variant KCNIP4 isoform is also detrimental to brain physiology, as it results in the concomitant blockade of the fast kinetics of potassium channels. PMID: 21624954
    7. These data demonstrate that PKA phosphorylation of Kv4.2 plays an important role in the trafficking of Kv4.2 through its specific interaction with KChIP4a. PMID: 20045463
    8. cloning and investigation of interaction with presenilin 2 and voltage-gated potassium channel subunit Kv4 PMID: 11847232
    9. The conformational change with metal-bound KChIP4.1 is crucial for its interaction with Kv channel but not for KChIP2.2, and that the Mg2+- and Ca2+-binding properties of KChIP2.2 and KChIP4.1 have different effects on their molecular structure. PMID: 16951992
    10. Mutation of KCNIP4 is associated with renal cell carcinoma. PMID: 17981209
    11. CALP and calsenilin are involved in the trafficking of Golgi glycosyltransferases. PMID: 18269347
    12. These results reveal a new role for KChIP3 in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated. PMID: 18393943
    13. KChIP4a, KChIP2x, and KChIP3x comprise a novel class of KChIP isoforms characterized by an unusual transmembrane domain at their N termini that modulates Kv4 channel gating and trafficking. PMID: 18957440

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm.; [Isoform 4]: Endoplasmic reticulum.
  • 蛋白家族：
    Recoverin family
  • 組織特異性：
    Predominantly expressed in brain.
  • 數據庫鏈接：

    HGNC: 30083

    OMIM: 608182

    KEGG: hsa:80333

    STRING: 9606.ENSP00000371587

    UniGene: Hs.655705



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