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  4. KCNIP1 Antibody

KCNIP1 Antibody

  • 中文名稱：
    KCNIP1兔多克隆抗體
  • 貨號：
    CSB-PA585744
  • 規格：
    ￥1090
  • 圖片：
    • Immunohistochemical analysis of paraffin-embedded Mouse BrainTissue using KChIP1 Rabbit pAb diluted at 1:200.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    KCNIP1
  • 別名：
    A type potassium channel modulatory protein 1 antibody; A-type potassium channel modulatory protein 1 antibody; KChIP1 antibody; KCIP1_HUMAN antibody; Kcnip1 antibody; Kv channel interacting protein 1 antibody; Kv channel-interacting protein 1 antibody; MGC9 antibody; MGC95 antibody; Potassium channel interacting protein 1 antibody; Potassium channel-interacting protein 1 antibody; VABP antibody; Vesicle APC binding protein antibody; Vesicle APC-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic Peptide
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    IHC,ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC IHC-p:1:100-200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Increases the presence of KCND2 at the cell surface.
  • 基因功能參考文獻：
    1. This is the first copy number variation association study of the KCNIP1 gene in Chinese population, and these data indicated that KCNIP1 might function as a type 2 diabetes-susceptibility gene whose dysregulation alters insulin production. PMID: 29491224
    2. Study shows that the VAPB-PTPIP51 tethers regulate autophagy and demonstrates that overexpression of VAPB or PTPIP51 to tighten endoplasmic reticulum-mitochondria contacts impairs, whereas small interfering RNA-mediated loss of VAPB or PTPIP51 to loosen contacts stimulates, autophagosome formation. PMID: 28132811
    3. the current study provides evidence that genetic variants of Kv accessory proteins may contribute to the susceptibility of Attention-deficit/hyperactivity disorder. PMID: 29176790
    4. These studies showed that a common copy number variation in KCNIP1 gene is a genetic predictor of atrial fibrillation risk possibly pointing to a functional pathway. PMID: 26831368
    5. KCNIP1 from copy number variations study might function as a type 2 diabetes susceptibility gene whose dysregulation alters insulin production. PMID: 24886904
    6. Protein aggregation due to nsSNP resulting in P56S VABP protein is associated with amyotrophic lateral sclerosis PMID: 24681403
    7. V234I-VAPB induces ubiquitin aggregation followed by cell death; proposed that V234I-VAPB exhibits the characteristics of amyotrophic lateral sclerosis in spite of not having the typical aggregation property of different mutations in various neurodegenerative diseases PMID: 24792378
    8. our findings suggest that KChIP1 interacts with Kv4.3 in interneurons at the stratum lacunosum-moleculare/radiatum junction PMID: 21129448
    9. X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites. PMID: 17057713
    10. EF-hands 3 and 4 of KChIP1 are functionally involved in a specific association with PS on the membrane PMID: 19550036

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  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein. Cytoplasm. Cell projection, dendrite.
  • 蛋白家族：
    Recoverin family
  • 組織特異性：
    Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus.
  • 數據庫鏈接：

    HGNC: 15521

    OMIM: 604660

    KEGG: hsa:30820

    STRING: 9606.ENSP00000395323

    UniGene: Hs.484111



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