在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. KCNC1 Antibody

KCNC1 Antibody

  • 中文名稱：
    KCNC1兔多克隆抗體
  • 貨號：
    CSB-PA003120
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of K562 cells using KV3.1 Polyclonal Antibody
    • Western Blot analysis of K562 cells using KV3.1 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    KCNC1
  • 別名：
    KCNC1; Potassium voltage-gated channel subfamily C member 1; NGK2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human KV3.1.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2, and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons.
  • 基因功能參考文獻：
    1. A recurrent de novo mutation in KCNC1 (c.959G>A, p.Arg320His) has been identified recently as one of the important genetic causes of progress myoclonic epilepsy. This recurrent mutation in KCNC1 was identified in the two brothers who showed characteristic features of myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK). The asymptomatic mother was suspected as being mosaic for this mutation. PMID: 29428275
    2. KNCN1 p.R320H mutation causes MEAK syndrome. PMID: 28380698
    3. A nonsense variant in KCNC1 gene was identified in three family members with intellectual disability without seizures. PMID: 28145425
    4. reviews the phenotype/genotype of progressive myoclonus epilepsy and ataxia due to potassium channel mutation (MEAK)associated with KCNC1 mutations [review] PMID: 27629860
    5. KCNC1 produces a resurgent current during repolarization, ensuring enough repolarizing power to terminate each action potential. The current results from a combination of steep voltage-dependent gating kinetics and ultra-fast voltage-sensor relaxation. PMID: 26673941
    6. A recurrent KCNC1 de novo mutation, c.959G>A (p.Arg320His), is a new major cause for progressive myoclonus epilepsy. It has a dominant-negative loss-of-function effect. PMID: 25401298
    7. Findings show a decrease in Kv3.1b channel protein in schizophrenia neocortex, a deficit that is restored by antipsychotic drugs PMID: 23628987
    8. Describes localization in mouse brain of two isoforms - the longer is called b and the shorter is called a. PMID: 12091563
    9. Describes two rat isoforms of Kv3.1, alpha is the longer one and beta is the shorter one PMID: 1432046
    10. KChIP4a suppresses A-type Kv4 current via ER retention and enhancement of Kv4 closed-state inactivation. PMID: 23576435
    11. Although all KV3 subunit transcripts are significantly expressed at embryonic age in whole mouse brain extracts, only KV3.1, KV3.2 and KV3.4 subunit transgenic proteins are present. PMID: 21912965
    12. demonstrated that glycosylation was necessary for both DPP10 trafficking to the cell surface and functional interaction with Kv4 channels PMID: 22387313
    13. Kv3.1 channels are transported into axons by binding to kinesin I. PMID: 21106837

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Epilepsy, progressive myoclonic 7 (EPM7)
  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell junction, synapse, presynaptic cell membrane.
  • 蛋白家族：
    Potassium channel family, C (Shaw) (TC 1.A.1.2) subfamily, Kv3.1/KCNC1 sub-subfamily
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6233

    OMIM: 176258

    KEGG: hsa:3746

    STRING: 9606.ENSP00000265969

    UniGene: Hs.552896



主站蜘蛛池模板： 高潮又爽又无遮挡又免费| 搡女人真爽免费视频大全| 精品国产一区二区三区四区| 国产精品久久久久久久久久久久午夜片| 成年女人色毛片| 国产99视频精品专区| 未满十八18禁止午夜免费网站 | 午夜丰满少妇性开放视频| 欧美老熟妇xb水多毛多| 亚洲国精产品一二二线| 亚洲处破女av日韩精品波波网| 亚洲人成电影在线天堂色| 青青青国产精品一区二区| 国产午夜福利片| 国产精品乱子伦xxxx裸| 熟女人妻av完整一区二区三区| 国产女人好紧好爽| 猫咪av成人永久网站在线观看| 国产精品夜夜春夜夜爽久久| 亚洲综合色视频在线观看| 亂倫近親相姦中文字幕| 69久久国产露脸精品国产| 中文字幕乱码免费专区| 亚洲欧洲日产国无高清码图片 | 国产在线观看片a免费观看| 久久久肥妇熟女ⅹxxx毛片| 国产精品区av| 久久免费的精品国产v∧| 忍着娇喘人妻被中出中文字幕| 色噜噜亚洲男人的天堂www| 亚洲国产精品美女久久久久| 亚洲综合一区无码精品| 国产情侣疯狂作爱系列| 久久青青草原精品国产| 国语精品一区二区三区| 亚洲日韩看片无码电影| av性色av久久无码ai换脸| 女人下边被添全过视频| 玩弄漂亮少妇高潮白浆| 美女裸免费观看网站| 无码人妻aⅴ一区二区三区|