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  4. KCMF1 Antibody, Biotin conjugated

KCMF1 Antibody, Biotin conjugated

  • 中文名稱：
    KCMF1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA873718LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) KCMF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KCMF1
  • 別名：
    KCMF1 antibody; FIGC antibody; ZZZ1 antibody; E3 ubiquitin-protein ligase KCMF1 antibody; EC 2.3.2.27 antibody; FGF-induced in gastric cancer antibody; Potassium channel modulatory factor antibody; PCMF antibody; RING-type E3 ubiquitin transferase KCMF1 antibody; ZZ-type zinc finger-containing protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase KCMF1 protein (98-226AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has intrinsic E3 ubiquitin ligase activity and promotes ubiquitination.
  • 基因功能參考文獻：
    1. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4. PMID: 25582440
    2. Data indicate that expressions of miR-210 and potassium channel modulatory factor 1 (KCMF1) exhibited an inverse correlation in placentas from patients with severe preeclampsia. PMID: 24980667
    3. Data indicate that FIGC upregulation in response to basic fibroblast growth factor in gastric cancer might be implicated in carcinogenesis through dysregulation of growth modulator. PMID: 15581609
    4. Suppression of KCMF1 by constitutive high CD99 expression levels contribute to the malignant properties of Ewing's sarcoma by promoting growth and migration of tumor cells PMID: 16314831
  • 蛋白家族：
    KCMF1 family
  • 組織特異性：
    Spleen, small intestine, ovary, peripheral blood, lung, kidney and pancreas. Expressed at low levels in the thymus, prostate, testis, colon, heart, brain, placenta and liver.
  • 數據庫鏈接：

    HGNC: 20589

    OMIM: 614719

    KEGG: hsa:56888

    STRING: 9606.ENSP00000386738

    UniGene: Hs.654968



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