在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KAT7 Antibody

  • 中文名稱:
    KAT7兔多克隆抗體
  • 貨號:
    CSB-PA002860
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of Jurkat cells using HBO1 Polyclonal Antibody
    • Western Blot analysis of various cells using HBO1 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    KAT7
  • 別名:
    Hbo 1 antibody; HBO1 antibody; HBOa antibody; Histone acetyltransferase binding to hORC1 antibody; Histone acetyltransferase binding to ORC1 antibody; Histone acetyltransferase KAT7 antibody; Histone acetyltransferase MYST2 antibody; K(lysine) acetyltransferase 7 antibody; KAT 7 antibody; KAT7 antibody; Lysine acetyltransferase 7 antibody; MOZ antibody; MOZ YBF2/SAS3 SAS2 and TIP60 protein antibody; MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 antibody; MYST 2 antibody; MYST histone acetyltransferase 2 antibody; MYST protein 2 antibody; MYST-2 antibody; MYST2 antibody; MYST2_HUMAN antibody; SAS 2 antibody; SAS2 and TIP60 protein 2 antibody; TIP60 protein 2 antibody; YBF2/SAS3 antibody; ZC2HC7 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human HBO1.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development. Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation. Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4. H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II. Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation. H3K14ac is also required for T-cell development. KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing. Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange. Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites. Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity.; Plays a central role in the maintenance of leukemia stem cells in acute myeloid leukemia (AML). Acts by mediating acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby facilitating the processivity of RNA polymerase II to maintain the high expression of key genes, such as HOXA9 and HOXA10 that help to sustain the functional properties of leukemia stem cells.
  • 基因功能參考文獻:
    1. acts in concert with SNF2H-ACF1 to make the chromosome structure more accessible to canonical nucleotide excision repair factors PMID: 28719581
    2. Hbo1 is another ERalpha coactivator that ubiquitinates ERalpha PMID: 28769019
    3. Histone acetyltransferase binding to ORC1 (HBO1) is upregulated in bladder cancer. PMID: 28796367
    4. The results demonstrate some connections between KAT7 upregulated in RA SFs and RA progression and present the inhibition of KAT7 activity as a novel therapeutic target for interfering RA disease. PMID: 28552525
    5. Structural and mechanistic insights into regulation of HBO1 histone acetyltransferase activity by BRPF2 have been presented. PMID: 28334966
    6. KAT7-containing acetyltransferases associating with the Mis18 complex provides competence for histone turnover/exchange activity on alphoid DNA and prevents Suv39h1-mediated heterochromatin invasion into centromeres. PMID: 27270040
    7. the possible binding sites and biological functions of HBO1, were identified. PMID: 27247147
    8. Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ) represses p53 activity by direct inhibition of the histone acetyltransferase (HAT) activity of p300/CBP and the HAT activity of HBO1: [HBZ] PMID: 26625199
    9. This study demonstrates that CRL4(DDB2) is a novel ubiquitin ligase of HBO1. PMID: 26572825
    10. Taken together, MYST2 is a repressed growth suppressor in AML mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival. PMID: 26072331
    11. Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter PMID: 25743411
    12. Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 shuttling during organ regeneration. PMID: 24739512
    13. Hbo1 modulated transcription by estrogen receptor-alpha. Hbo1 contributes to degradation of ER-alpha by ubiquitination through lysine 48. PMID: 24125069
    14. Phosphorylated Hbo1 expression is associated with breast cancer. PMID: 23955388
    15. alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails PMID: 24065767
    16. Gemcitabine resistance is dependent on Plk1-mediated phosphorylation of Orc2 and Hbo1. PMID: 23188630
    17. Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels. PMID: 23319590
    18. The protein domains required for the assembly and function of HBO1/ING complexes were shown. Multiple PHD finger domains in different subunits bound the histone H3 N-terminal tail with a specificity towards lysine 4 methylation. PMID: 22144582
    19. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress PMID: 21856198
    20. HBO1 was an important downstream molecule of ERalpha. PMID: 21040551
    21. HBO1 promote MCM loading in vivo involves the stimulation of large-scale chromatin decondensation to allow access to the underlying DNA substrate. PMID: 20980834
    22. results show that ING4 is a bivalent reader of the chromatin H3K4me3 modification and suggest a mechanism for enhanced targeting of the HBO1 complex to specific chromatin sites PMID: 20053357
    23. H4 acetylation at origins by HBO1 is critical for DNA replication licensing. PMID: 20129055
    24. inhibition by Set/TAF-1beta inhibits active demethylation of DNA, integrating DNA methylation and transcriptional silencing PMID: 11978794
    25. ordered recruitmenet to thyroid hormone-responsive promoters in vivo PMID: 12034878
    26. Hbo1 is a positive regulatory factor for prereplicative complex assembly. PMID: 16428461
    27. histone acetyltransferase binding to ORC-1 might play an important physiological role in human progesterone receptor signaling PMID: 16645042
    28. reveal a direct regulatory connection between p53-responsive stress signaling and Hbo1-dependent chromatin pathways PMID: 17954561
    29. Hbo1 depletion results in decreased DNA replication and a failure of Mcm complex binding to chromatin, both of which can be partially rescued by the ectopic expression of WT Hbo1 but not Hbo1-S57A PMID: 18250300
    30. Jade-1/1L are crucial co-factors for HBO1-mediated histone H4 acetylation PMID: 18684714
    31. HBO1 associates with replication origins specifically during the G1 phase of the cell cycle in a manner that depends on the replication licensing factor Cdt1, but is independent of the Cdt1 repressor Geminin. PMID: 18832067
    32. Overexpression of MYST2 is associated with breast cancer. PMID: 19372580
    33. Immunohistochemistry for Hbo1 in 11 primary human tumor types revealed strong Hbo1 protein expression in carcinomas of the testis, ovary, breast, stomach/esophagus, and bladder. PMID: 19393168

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Chromosome. Chromosome, centromere. Cytoplasm, cytosol.
  • 蛋白家族:
    MYST (SAS/MOZ) family
  • 組織特異性:
    Ubiquitously expressed, with highest levels in testis.
  • 數據庫鏈接:

    HGNC: 17016

    OMIM: 609880

    KEGG: hsa:11143

    STRING: 9606.ENSP00000259021

    UniGene: Hs.21907



主站蜘蛛池模板: 影音先锋男人av鲁色资源网| 欧美亚洲色aⅴ大片| 潮喷失禁大喷水av无码| 欧美性xxxxx极品少妇直播| 久9re热视频这里只有精品| 久久国产成人免费网站| 亚洲中文有码字幕日本| 日韩a片无码一区二区三区电影| 亚洲精品无码ma在线观看 | 亚洲欧美日韩精品久久| 婷婷久久综合九色综合88| 国产国拍精品av在线观看| 欧美黑人又粗又大xxx| 亚洲人成网站18禁止大app| 国产呻吟久久久久久久92| 日韩精品人妻中文字幕有码| 成 人 亚洲 综合天堂| 久久精品国产成人午夜福利| 日韩激情无码不卡码| 天天狠天天天天透在线| 色综合色狠狠天天综合网| 欧美老肥妇多毛xxxxx| 亲嘴扒胸摸屁股激烈网站 | 国产亚洲欧美另类一区二区| 动漫av纯肉无码av电影网| 久久天堂av综合合色| 男女作爱免费网站| 久久久精品欧美一区二区免费| 4480yy私人精品国产| 任我爽橹在线视频精品583| 久久精品国产清自在天天线| 99精品国产一区二区三区| 国产又粗又猛又爽的视频a片| 永久免费看啪啪网址入口| 极品尤物一区二区三区| 久久久久无码中| 蜜桃日本免费观看mv| 亚洲国产精品无码中文lv| 美女脱了内裤张开腿让男人桶网站| 国产二级一片内射视频播放| 熟女chachacha性少妇|