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KAP95 Antibody

  • 中文名稱：
    KAP95 Antibody
  • 貨號：
    CSB-PA012490XA01SVG
  • 規格：
    ￥880
  • 圖片：
    • Western Blot
      Positive WB detected in: recombinant protein
      All lanes:KAP95 Antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/20000 dilution
      Predicted band size: 34.6 kDa
      Observed band size: 34 kDa
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP95 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    KAP95
  • 別名：
    Importin subunit beta-1 (Importin-95) (Karyopherin subunit beta-1) (Karyopherin-95) KAP95 YLR347C L8300.15
  • 宿主：
    Rabbit
  • 反應種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 免疫原：
    Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) KAP95 protein (611-861aa)
  • 免疫原種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:5000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Importin beta subunit that functions in nuclear protein import through association with the importin alpha subunit, which binds to the classical nuclear localization signal (cNLS) in cargo substrates. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by importin beta through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, GTP-Ran binds to importin beta and the three components separate, leading to release of the cargo. Importin alpha and beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin beta. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of histones H2A and H2B. Mediates the nuclear import of transcription factor GCN4.
  • 基因功能參考文獻：
    1. Data suggest that, in nuclear exosomes, karyopherins are bound to the Rrp6 complex; Srp1, Kap95, and Sxm1 appear to be the most important karyopherins for nuclear import of Rrp6. (Rrp6 = exosome nuclease subunit RRP6; Srp1 = karyopherin alpha kap60; Kap95 = karyopherin beta Kap95; Sxm1 = karyopherin Kap108) PMID: 28539363
    2. The Kap95 is able to mediate efficient Mig2-Kap95 interaction in the absence of the importin-alpha. PMID: 23131016
    3. Hxk2 as a new cargo for the alpha/beta-importin pathway of S. cerevisiae. PMID: 22157003
    4. Kap95 is likely the primary karyopherin responsible for Replication protein A nuclear import in yeast. PMID: 21332387
    5. The authors identified karyopherin Kap95 as the transport factor responsible for the nuclear import of Slt2 and Rlm1. PMID: 19930464
    6. identification of a key interaction site where the RanGTP switch I loop binds to the carboxy-terminal arch of Kap95p PMID: 15864302
    7. There is a correlation between the binding affinity of an NLS cargo for the NLS receptor, importin alpha, and the import rate for this cargo. PMID: 16785238
    8. Kap95 serves as a key regulator of nuclear pore complex assembly into intact nuclear envelopes. PMID: 17182855
    9. Data show the crystal structure of the Kap95p-RanGDP complex shows that Kap95p induces the switch I and II regions of RanGDP to adopt a conformation that resembles that of the GTP-bound form. PMID: 18708071
    10. Pct1 interacts with Kap60 and Kap95 with this tripartite complex transiting the nuclear pore. PMID: 19141610

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Nucleus, nuclear pore complex.
  • 蛋白家族：
    Importin beta family, Importin beta-1 subfamily
  • 數據庫鏈接：

    KEGG: sce:YLR347C

    STRING: 4932.YLR347C



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