在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

JMJD6 Antibody

  • 中文名稱:
    JMJD6兔多克隆抗體
  • 貨號:
    CSB-PA988498
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA988498(JMJD6 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse liver tissue, Primary antibody: CSB-PA988498(JMJD6 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    JMJD6
  • 別名:
    Apoptotic cell clearance receptor antibody; Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 antibody; Histone arginine demethylase JMJD6 antibody; JmjC domain-containing protein 6 antibody; JMJD 6 antibody; JMJD6 antibody; JMJD6_HUMAN antibody; Jumonji domain containing 6 antibody; Jumonji domain-containing protein 6 antibody; KIAA0585 antibody; Lysyl-hydroxylase JMJD6 antibody; Peptide-lysine 5-dioxygenase JMJD6 antibody; Phosphatidylserine receptor antibody; Protein PTDSR antibody; PSR antibody; PTDSR 1 antibody; PTDSR antibody; PTDSR1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human JMJD6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Dioxygenase that can both act as a arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Regulates RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. Hydroxylates its own N-terminus, which is required for homooligomerization. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which preferentially demethylates asymmetric dimethylation. Demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), including mono-, symmetric di- and asymmetric dimethylated forms, thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. In collaboration with BRD4, interacts with the positive transcription elongation factor b (P-TEFb) complex in its active form to regulate polymerase II promoter-proximal pause release for transcriptional activation of a large cohort of genes. On distal enhancers, so called anti-pause enhancers, demethylates both histone H4R3me2 and the methyl cap of 7SKsnRNA leading to the dismissal of the 7SKsnRNA:HEXIM1 inhibitor complex. After removal of repressive marks, the complex BRD4:JMJD6 attract and retain the P-TEFb complex on chromatin, leading to its activation, promoter-proximal polymerase II pause release, and transcriptional activation. Demethylates other arginine methylated-proteins such as ESR1. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.
  • 基因功能參考文獻:
    1. JMJD6 regulates VHL gene expression in the human placenta. VHL downregulation in preeclampsia is dependent on decreased JMJD6 demethylase activity due to hypoxia and reduced Fe2+ bioavailability. PMID: 29373688
    2. In tumor samples but not normal breast tissue, the expression of JMJD6 linearly correlated with HOTAIR suggesting that JMJD6-mediated up-regulation may occur specifically in tumors. PMID: 29229759
    3. Results show that JMJD6 is up-regulated in melanoma, and high expression of JMJD6 protein is strongly correlated with advanced stages and aggressiveness of melanoma. It enhances the MAPK signaling through regulation of alternative splicing of PAK1 promoting multiple cellular processes including melanogenesis, proliferation, invasion, and angiogenesis in melanoma cells. PMID: 29187213
    4. High JMJD6 expression is associated with Neuroblastomas. PMID: 28684529
    5. miR-770 acted on a tumor suppressor by binding to the 3'UTR of JMJD6 and downregulated its expression in NSCLC cells; this study also demonstrated that JMJD6 played as an oncogene in NSCLC cells PMID: 28882645
    6. AcK27-HOXB9 suppresses the transcription of its target gene Jumonji domain-containing protein 6 (JMJD6) by direct occupying the promoter of JMJD6 gene. PMID: 27613418
    7. These findings provide evidence that JMJD6 may play a role in regulating the production of sFLT-1 in the preeclamptic placenta. Decreased placental JMJD6 expression may be an important component to the pathophysiology of preeclampsia. PMID: 26819475
    8. Study identified a novel epigenetic mechanism showing how JMJD6 cooperates with Myc during oncogenic transformation. Combined high expression of Myc and JMJD6 confers a more aggressive phenotype in mouse and human tumors. PMID: 27081402
    9. Our studies identify JMJD6 as a molecular determinant of cancer stem cell phenotype PMID: 26645717
    10. Although JMJD6 displays anti-tumoral properties in cell lines, its expression in breast tumours may be a marker of poor prognosis, suggesting that its function could be altered in breast cancer PMID: 25951181
    11. The expression of JMJD6 was reduced in T lymphocytes in chronic hepatitis B. PMID: 25219359
    12. A novel role for JMJD6 as an oxygen sensor in the human placenta, and alterations in the JMJD6-VHL-HIF1A feedback loop may indirectly contribute to elevated HIF1A found in preeclampsia. PMID: 26037477
    13. JMJD6 is a potential biomarker for colon cancer aggressiveness and a potential target for colon cancer intervention. PMID: 24667498
    14. Study reports that a unique cohort of JMJD6 and Brd4 cobound distal enhancers, termed anti-pause enhancers, regulate promoter-proximal pause release of a large subset of transcription units via long-range interactions. PMID: 24360279
    15. The structure of Jmjd6 oligomers in vitro changes in the absence of the polyS domain, possibly reflecting the role of the polyS domain in nuclear/nucleolar shuttling of Jmjd6. PMID: 23688307
    16. results showed that JMJD6 plays a key role in lung adenocarcinoma and therefore may provide an opportunity for developing a novel therapeutic target as well as a prognostic marker in lung adenocarcinoma. PMID: 23595221
    17. histones are additional substrates of JMJD6 in vivo. Because 5-hydroxylation of lysyl residues inhibited N-acetylation and N-methylation by an acetyltransferase and a methyltransferase PMID: 23303181
    18. data indicate JMJD6 has conserved functions and often affects similar pathways across multiple cell types; it has ability to promote cancer cell proliferation and motility; JMJD6 is a novel biomarker of tumor aggressiveness with functional implications in breast cancer growth and migration PMID: 22621393
    19. Endothelial microparticles are incorporated by endothelial cells in an annexin I/phosphatidylserine receptor-dependent manner and protect target cells against apoptosis. PMID: 22701020
    20. we did not detect arginine demethylase activity for Jmjd6, but we did confirm that it could catalyze the lysyl-hydroxylation of histone peptides PMID: 22189873
    21. Jmjd6 regulates the splicing of Flt1, thereby controlling angiogenic sprouting. PMID: 21300889
    22. Data show that JMJD6 bound efficiently to single-stranded RNA, but not to single-stranded DNA, double-stranded RNA, or double-stranded DNA. PMID: 20679243
    23. crystallographic studies on the catalytic domain of JMJD6 in complex with Ni(II) substituting for Fe(II) PMID: 20684070
    24. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. PMID: 11877474
    25. plays a major role in the clearance of apoptotic cells from the thymus. PMID: 15072554
    26. Homomultimer of PS-R might be playing an important function as a scaffolding protein in the nucleus. PMID: 17534701
    27. study demonstrates that JMJD6 is a JmjC-containing iron- and 2-oxoglutarate-dependent dioxygenase that demethylates histone H3 at arginine 2 (H3R2) and histone H4 at arginine 3 (H4R3) in both biochemical and cell-based assays PMID: 17947579
    28. Jmjd6 is predicted to have a conserved enzymatic function as a classical non-heme, Fe(II)- and 2OG-dependent dioxygenase, and is closely related to the JmjC domain-containing proteins Jmjd4 and JFP6. PMID: 18564434
    29. Jmjd6 serves as a membrane-associated receptor that regulates phagocytosis in immature macrophages but is dispensable for phagocytosis. PMID: 19492415
    30. study reveals the splicing factor U2AF65 undergoes posttranslational lysyl-5-hydroxylation catalyzed by Jmjd6; Jmjd6 is shown to change alternative RNA splicing of some endogenous & reporter genes, supporting a role for Jmjd6 in regulation of RNA splicing PMID: 19574390
    31. The mouse ortholog of Ptdsr is essential for the development and differentiation of multiple organs during embryogenesis but not for apoptotic cell clearance. PMID: 15345036

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleoplasm. Nucleus, nucleolus. Cytoplasm.
  • 蛋白家族:
    JMJD6 family
  • 組織特異性:
    Highly expressed in the heart, skeletal muscle and kidney. Expressed at moderate or low level in brain, placenta, lung, liver, pancreas, spleen, thymus, prostate, testis and ovary. Up-regulated in many patients with chronic pancreatitis. Expressed in nurs
  • 數據庫鏈接:

    HGNC: 19355

    OMIM: 604914

    KEGG: hsa:23210

    STRING: 9606.ENSP00000394085

    UniGene: Hs.514505



主站蜘蛛池模板: 亚洲中文字幕aⅴ无码天堂 | 亚洲自偷自拍熟女另类| av色欲无码人妻中文字幕| 日本成本人片视频免费| 国产在线aaa片一区二区99| 日本熟妇人妻xxxxx人hd| 双乳奶水饱满少妇呻吟免费看| 亚洲人毛茸茸bbxx| 国产日韩一区二区三免费高清| 久久精品国产最新地址| 亚洲国产日韩在线人成蜜芽| 成人亚洲欧美激情在线电影| 草色噜噜噜av在线观看香蕉| 又大又粗又爽的少妇免费视频| 性男女做视频观看网站| 一本热久久sm色国产| 非洲黑人最猛性xxxx交| 欧美成人免费全部观看国产| 午夜成人亚洲理论片在线观看| 野花社区www视频最新资源| 国产又粗又猛又黄又爽无遮挡| 精品国产乱码久久久久久影片| 99久久国语露脸精品国产色| 亚洲精品无码乱码成人| 暴力调教一区二区三区| 99国产精品自在自在久久| 一本久道久久综合狠狠老| 亚洲国产精品无码中文lv| 18禁免费无码无遮挡不卡网站| 亚洲精品动漫免费二区| 国产亚洲精aa在线观看不卡| 狠狠做五月深爱婷婷| 日本无码欧美一区精品久久| 99久久精品免费看国产一区二区| 亚洲 欧美精品suv| 欧美巨大巨粗黑人性aaaaaa| 欧美午夜理伦三级在线观看| 人人揉揉揉香蕉大免费| 中文无码精品一区二区三区| 亚洲鲁丝片一区二区三区| 女人的天堂a国产在线观看 |