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  4. JARID2 Antibody, FITC conjugated

JARID2 Antibody, FITC conjugated

  • 中文名稱：
    JARID2兔多克隆抗體, FITC偶聯(lián)
  • 貨號：
    CSB-PA852915HC01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) JARID2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    JARD2 antibody; JARD2_HUMAN antibody; JARID2 antibody; JMJ antibody; Jumonji AT rich interactive domain 2 antibody; Jumonji homolog antibody; Jumonji like protein antibody; Jumonji protein antibody; Jumonji/ARID domain containing protein 2 antibody; Jumonji/ARID domain-containing protein 2 antibody; Protein Jumonji antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Protein Jumonji protein (1-159AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts as an accessory subunit for the core PRC2 (Polycomb repressive complex 2) complex, which mediates histone H3K27 (H3K27me3) trimethylation on chromatin. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells, thereby playing a key role in stem cell differentiation and normal embryonic development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Does not have histone demethylase activity.
  • 基因功能參考文獻：
    1. rs2237126 in JARID2 is not significantly associated with childhood autism spectrum disorder or the severity of the disease in a Chinese Han population. PMID: 29216786
    2. The knockdown of JARID2 inhibited the viability and invasion of trophoblast cells in preeclampsia by suppressing the PI3K/Akt signaling pathway. PMID: 28714012
    3. bservations suggested that knockdown of JARID2 inhibited proliferation, migration and invasion in vitro through the inactivation of the PI3K/Akt signaling pathway. Therefore, JARID2 may represent a potential therapeutic target for the treatment of ovarian cancer. PMID: 28765957
    4. Authors found that knockdown of Jarid2 was able to inhibit the invasive ability and sphere-forming capacity in bladder cancer cells. PMID: 28445934
    5. Our results suggest that JARID2 rs2237138 shows a protective effect against NSCL +/- P (non-syndromic oral clefts)in the Brazilian population. PMID: 27328068
    6. JARID2 promotes invasion and metastasis of hepatocellular carcinoma by facilitating epithelial-mesenchymal transition through PTEN/AKT signaling PMID: 27259236
    7. JARID2 plays an important role in glioma development. PMID: 27641964
    8. Data further strengthen the conclusion that JARID2 polymorphisms are associated with NSOC susceptibility. PMID: 25155265
    9. JARID2 inhibits leukemia cell proliferation by regulating CCND1 expression PMID: 25939703
    10. TGF-ss-dependent expression changes of EMT-related genes were inhibited by JARID2 knockdown and enhanced by JARID2 overexpression. PMID: 25542019
    11. Results suggest a regulation loop where Jarid2 protein methylation fine-tunes polycomb repressive complex 2 (PRC2) activity depending on the chromatin context. PMID: 25620564
    12. Jarid2 is an important component of PRC2 that has a central role in coordinating hematopoietic stem and progenitor cell function PMID: 25645357
    13. Decreased miRNA-940 affects the proliferation and migration of the progenitor cells of the secondary heart field by targeting JARID2. PMID: 24889693
    14. miR-155 regulates the fate of Th17 and Treg cells and miR-155 contributes to Th17 cell function by suppressing the inhibitory effects of Jarid2. PMID: 24856900
    15. The interaction of JARID2 at these promoters is dependent on EED. PMID: 23435416
    16. Jarid2 is an important mediator of Xist-induced PRC2 targeting. PMID: 24462204
    17. The presence of long noncoding RNAs stimulated JARID2-EZH2 interactions in vitro and JARID2-mediated recruitment of PRC2 to chromatin. PMID: 24374312
    18. Patients carrying JARID2 deletion manifested with cognitive impairment, gait disturbance and a characteristic facial appearance, whereas patients with deletion of ATXN1 seemed to be characterized by intellectual disability and behavioural abnormalities PMID: 23294540
    19. In chronic myeloproliferative neoplasms & myelodysplastic syndromes, there were frequent deletions in a 1.1 Mb region of the short arm of chromosome 6 containing only the JARID2 gene. This del6p was associated with leukemic transformation. PMID: 22190018
    20. JARID2 is essential for the binding of PcG proteins to target genes and, consistent with this, for the proper differentiation of embryonic stem cells and normal development PMID: 20075857
    21. Two SNPs in JARID2 showed association in allelic, genotypic and haplotypic tests with schizophrenia patients from Chang Le area. PMID: 19884986
    22. JMJ was evaluated against risk factors for spinal dysraphism and congenital heart defects. Variations within exons and introns of JMJ might be in linkage disequlibrium. PMID: 15057990
    23. JARID2 should be viewed as a candidate gene for 6p22.3-linked schizophrenia PMID: 16967465
    24. JARID2 appears important in transcriptional regulation of fetal genes and may emerge as a diagnostic marker for left ventricular decompensation in aortic stenosis. PMID: 18805276
    25. Based on the findings the authors propose that miR-155 has a prosurvival function that is mediated through the downregulation of targets including JARID2. PMID: 19759154

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6196

    OMIM: 601594

    KEGG: hsa:3720

    STRING: 9606.ENSP00000341280

    UniGene: Hs.269059



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