IZUMO1 Antibody
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中文名稱：IZUMO1兔多克隆抗體
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貨號：CSB-PA812903LA01HU
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規格：￥440
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圖片：
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA812903LA01HU at dilution of 1:100 -
Immunofluorescent analysis of A549 cells using CSB-PA812903LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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其他：
產品詳情
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產品名稱：Rabbit anti-Homo sapiens (Human) IZUMO1 Polyclonal antibody
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Uniprot No.：
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基因名：IZUMO1
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別名：FLJ61440 antibody; IZUM1_HUMAN antibody; IZUMO antibody; Izumo sperm egg fusion 1 antibody; Izumo sperm-egg fusion protein 1 antibody; Izumo1 antibody; MGC34799 antibody; OBF antibody; Oocyte binding/fusion factor antibody; Sperm specific protein izumo antibody; Sperm-specific protein izumo antibody
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宿主：Rabbit
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反應種屬：Human
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免疫原：Recombinant Human Izumo sperm-egg fusion protein 1 protein (22-292AA)
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免疫原種屬：Homo sapiens (Human)
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標記方式：Non-conjugated
本頁面中的產品，IZUMO1 Antibody (CSB-PA812903LA01HU)，的標記方式是Non-conjugated。對于IZUMO1 Antibody，我們還提供其他標記。見下表：
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克隆類型：Polyclonal
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抗體亞型：IgG
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純化方式：>95%, Protein G purified
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濃度：It differs from different batches. Please contact us to confirm it.
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保存緩沖液：Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 -
產品提供形式：Liquid
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應用范圍：ELISA, IHC, IF
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推薦稀釋比：
Application Recommended Dilution IHC 1:20-1:200 IF 1:50-1:200 -
Protocols：
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儲存條件：Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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貨期：Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
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用途：For Research Use Only. Not for use in diagnostic or therapeutic procedures.
產品評價
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靶點詳情
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功能：Essential sperm cell-surface protein required for fertilization by acting as a ligand for IZUMO1R/JUNO receptor on egg. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion. The ligand-receptor interaction probably does not act as a membrane 'fusogen'.
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基因功能參考文獻：
- crystal structures of human IZUMO1, JUNO and the IZUMO1-JUNO complex, establishing the structural basis for the IZUMO1-JUNO-mediated sperm-oocyte interaction PMID: 27309808
- crystal structures of human IZUMO1 and JUNO in unbound and bound conformations PMID: 27309818
- these findings indicate that human sperm expresses Izumo protein, and the immunoinfertile female sera have circulating isoantibodies against this protein. PMID: 23279005
- human sperm contain Izumo and addition of the antibody against human Izumo left the sperm unable to fuse with zona-free hamster eggs [Izumo] PMID: 15759005
- We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions. PMID: 18082733
- Observational study of gene-disease association. (HuGE Navigator) PMID: 18082733
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亞細胞定位：Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle, acrosome membrane; Single-pass type I membrane protein.
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蛋白家族：Izumo family
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組織特異性：Sperm-specific (at protein level). Detectable on sperm surface only after the acrosome reaction.
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數據庫鏈接：
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