在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGB8 Antibody

  • 中文名稱:
    ITGB8兔多克隆抗體
  • 貨號:
    CSB-PA011892ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: ITGB8 antibody at 1.52µg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Lane 3: HepG2 whole cell lysate
      Lane 4: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 86, 72 kDa
      Observed band size: 86 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA011892ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) ITGB8 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ITGB8; Integrin beta-8
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Integrin beta-8 protein (43-320AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Integrin alpha-V:beta-8 (ITGAV:ITGB8) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligands. Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation on the surface of activated regulatory T-cells (Tregs) (Probable). Required during vasculogenesis.
  • 基因功能參考文獻:
    1. ITGB8 is identified as a novel target of miR-26a-5p. PMID: 29746867
    2. our results indicate that miR-199a-3p enhances cisplatinsensitivity of ovarian cancer cells through downregulating ITGB8 expression, and miR-199a-3p may serve as a therapeutic target for the treatment of ovarian cancer patients with cisplatin-resistance. PMID: 29436681
    3. In cellular model, the microRNA-513a-3p was identified as a novel element targeting ITG-beta8, thereby controlling the protein level and its molecular function in the controlling of migration and pro-inflammatory environment. PMID: 29204818
    4. Among Greek and Polish patients with intracerebral hemorrhage, heterozygous individuals with the rs10251386 and the rs10239099 of the ITGB8 gene had significantly lower age of ICH onset compared to the wild-type genotypes. PMID: 27476161
    5. The results demonstrated that the hsa_circ_0046701/miR-142-3p/ITGB8 axis might play critical regulatory roles in the pathogenesis and development of glioma. PMID: 29337055
    6. Integrin beta8 was differentially expressed between Fibromyalgia patients and healthy controls. PMID: 27157394
    7. Integrin Beta8 plays a role in the motility of prostate cancer cells. PMID: 25886373
    8. data show that integrin beta 8, but not integrin beta 5 or integrin beta 6, protein expression is increased in liver specimens of patients with biliary atresia PMID: 25079481
    9. Brain metastases ITGB8 expression exhibits considerable heterogeneity according to tumor origin. PMID: 24294359
    10. Desmoglein-2 co-localizes with integrin-beta8 in N-MVECs. PMID: 23874518
    11. ITGB8 silencing may change lung cancer cells to a less invasive phenotype through alteration in the expression of metastasis-related genes. PMID: 22753015
    12. Deletion of the Itgb8 gene from retinal ganglia cells and Mu ller glia, but not astrocytes, results in highly abnormal vascular patterning and instability. PMID: 22279205
    13. Highly angiogenic and poorly invasive glioblastomas expressed low levels of beta8 integrin, whereas highly invasive glioblastomas with limited neovascularization expressed high levels of beta8 integrin. PMID: 21859829
    14. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. PMID: 21878622
    15. miR-93 promotes the growth of, and angiogenesis in astrocytomas, by suppressing, at least in part, integrin-beta8 expression. PMID: 20956944
    16. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway PMID: 20519498

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin beta chain family
  • 組織特異性:
    Placenta, kidney, brain, ovary, uterus and in several transformed cells. Transiently expressed in 293 human embryonic kidney cells.
  • 數據庫鏈接:

    HGNC: 6163

    OMIM: 604160

    KEGG: hsa:3696

    STRING: 9606.ENSP00000222573

    UniGene: Hs.592171



主站蜘蛛池模板: 99久久久国产精品无码免费| 2019最新中文字幕在线观看| 窝窝午夜看片| 久久国产精品-国产精品| 亚洲欧美日韩中文播放| 国产午夜成人无码免费| 人妻丰满熟av无码区hd| 精品无码国产av一区二区| 久久精品国产久精国产一老狼| 国产在不卡免费一区二区三| 亚洲乱码伦小说区| 成人精品一区二区三区电影| 精品无码一区二区三区爱欲| 四十如虎的丰满熟妇啪啪| 丰满少妇人妻无码| 污污内射在线观看一区二区少妇| 中文在线а天堂| 日韩做a爰片久久毛片a片| 狠狠躁18三区二区一区| 免费视频欧美无人区码| 精品一区二区国产在线观看| 性亚洲videofree高清| 欧美牲交a欧美牲交aⅴ久久| 亚洲第一网站男人都懂| 欧美婷婷六月丁香综合| 茄子视频国产在线观看| 无遮无挡爽爽免费毛片| 国产九九99久久99大香伊| 国产精品久久自在自线不卡| 免费无码又爽又刺激激情视频软件| 日韩av无码中文无码不卡电影| 两个人日本www免费版| 日本一卡2卡3卡4卡5卡精品视频 | 久久精品av麻豆| 亚洲.欧美.在线视频| 国产超碰人人爽人人做人人添 | 精品无码国产av一区二区| 国产精品无码专区久久久| 国产亚洲日韩一区二区三区| 国产精品一区二区久久国产| 国产xxxxx在线观看|