在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ITGB3BP Antibody

ITGB3BP Antibody

  • 中文名稱：
    ITGB3BP兔多克隆抗體
  • 貨號(hào)：
    CSB-PA622653DSR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA622653DSR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA622653DSR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ITGB3BP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ITGB3BP
  • 別名：
    ITGB3BP antibody; CENPR antibody; NRIF3Centromere protein R antibody; CENP-R antibody; Beta-3-endonexin antibody; Integrin beta-3-binding protein antibody; Nuclear receptor-interacting factor 3 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Centromere protein R protein (1-177AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
  • 基因功能參考文獻(xiàn)：
    1. The beta3-endonexin can act as a novel anti-angiogenic factor specifically in the response to hypoxia due to its negative impact on the activation of HIF-1. PMID: 24386901
    2. Data propose that CENP-P/O/R/Q/U self-assembles on kinetochores with varying stoichiometry and undergoes a pre-mitotic maturation step that could be important for kinetochores switching into the correct conformation for microtubule-attachment. PMID: 23028590
    3. The presence of various isoforms and the relationship between subcellular localization and integrin-activating function of beta(3)-endonexin is described. PMID: 11864709
    4. This protein downregulates urokinase-type plasminogen activator receptor promoter activity. PMID: 12244126
    5. Results suggest that breast cancer cells contain a novel "death switch" that can be specifically triggered by NRIF3 or death domain 1. PMID: 15082778
    6. Metastasis-associated protein 1 interacts with NRIF3, an estrogen-inducible nuclear receptor coregulator PMID: 15254226
    7. findings suggest that NRIF3-Ser28 is a physiologic target of Pak1 signaling and contributes to the enhanced NRIF3 co-activator activity, leading to coordinated potentiation of ERalpha transactivation PMID: 18521086

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore.; [Isoform 2]: Nucleus.; [Isoform 3]: Nucleus. Cytoplasm. Note=Isoform 3 is predominantly nuclear and weakly cytoplasmic.; [Isoform 4]: Cytoplasm.
  • 組織特異性：
    Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 6157

    OMIM: 605494

    KEGG: hsa:23421

    STRING: 9606.ENSP00000360133

    UniGene: Hs.166539



主站蜘蛛池模板： 丰满少妇做爰视频爽爽和| 国产在线无码一区二区三区| 伊人久久大香线蕉精品| 热99re久久精品这里都是精品免费| 久久久久九九精品影院| 在线观看的网站| 国内无遮挡18禁无码网站免费| 无码人妻一区二区三区四区av| 国产大片黄在线观看| 国产永久免费观看视频| 亚洲曰本av在线天堂| 天天爱天天做久久狼狼| www国产无套内射com| 中文字幕热久久久久久久| 亚洲色在线无码国产精品| 国产日韩未满十八禁止观看| 精品一区国产vr| 男受被做哭激烈娇喘gv视频 | 久久久一本精品99久久精品66| 丰满多毛的陰户视频| 99精品国产一区二区三区a片| 国产女人18毛片水真多1| 亚洲熟妇色xxxxx亚洲| 成人午夜无码精品免费看| 精品精品国产高清a毛片| 色av综合av综合无码网站| 狠狠躁夜夜躁人人爽天天古典| 国内精品伊人久久久久妇| 国产精欧美一区二区三区| 无码少妇精品一区二区免费动态| 伊人无码精品久久一区二区| h漫全彩纯肉无码网站| 国产精品久久久久久av| 亚洲中文字幕无码av永久| 日产欧美国产日韩精品| 97精品超碰一区二区三区 | 国产私拍大尺度在线视频| 欧美性video高清精品| 国产av国片精品jk制服丝袜| 天天av天天爽无码中文| 亚洲日韩在线a视频在线观看 |