在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGB1BP1 Antibody, Biotin conjugated

  • 中文名稱:
    ITGB1BP1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA011881LD01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ITGB1BP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    ITGB1BP1
  • 別名:
    ITGB1BP1 antibody; ICAP1Integrin beta-1-binding protein 1 antibody; Integrin cytoplasmic domain-associated protein 1 antibody; ICAP-1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Integrin beta-1-binding protein 1 protein (1-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter.
  • 基因功能參考文獻(xiàn):
    1. nuclear-cytoplasmic shuttling of ICAP1 influences both integrin activation and KRIT1 localization, presumably impacting nuclear functions of KRIT1. PMID: 28003363
    2. The cocrystal structure of ICAP1 in complex with krev interaction trapped protein (KRIT)1 is characterized here. PMID: 23695561
    3. The structural basis for KRIT1 antagonized ICAP1-modulated integrin-beta1 activation. PMID: 23317506
    4. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway. PMID: 22736399
    5. Identify ICAP1 as a novel regulator to prevent excessive sprouting angiogenesis. PMID: 20616313
    6. Site-directed mutagenesis showed that Leu(135), Ile(138), and Ile(139) of Icap1 alpha, and Leu(82) and Tyr(144), are required for the Icap1 alpha-beta(1) integrin interaction PMID: 11741908
    7. Integrin-binding protein also interacts with Krit 1 protein, cause of CCM1. (ICAP-1, integrin cytoplasmic domain-associated protein 1) PMID: 11854171
    8. beta(1) integrin viability signal in collagen matrices is transduced by focal adhesion kinase PMID: 15166238
    9. ICAP-1 shuttles between the nucleus and cytoplasm in a beta1 integrin-dependent manner PMID: 15703214
    10. TNF-alpha induced expression of c-IAP1 and c-IAP2 via MAP kinases, but not via NF-kappaB, and that MAP kinases participated in the inhibition of apoptosis by induction of c-IAPs in TNF-alpha-stimulated endothelial cells PMID: 17133355
    11. integrin cytoplasmic domain-associated protein-1 alpha (icap1alpha) act concordantly to play a critical role in beta1-integrin-mediated cell proliferation. PMID: 18812969

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in a integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen.
  • 組織特異性:
    Expressed in endothelial cells and fibroblasts (at protein level). Ubiquitously expressed. Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 23927

    OMIM: 607153

    KEGG: hsa:9270

    STRING: 9606.ENSP00000347504

    UniGene: Hs.467662



主站蜘蛛池模板: 免费无码黄网站在线看| 欧美黑人巨大xxxxx视频| 久久无码高潮喷水| 污污内射在线观看一区二区少妇| 亚洲精品专区在线观看| 免费无码又爽又刺激高潮的动态图 | 无线日本视频精品| 丰满的少妇hd高清中文字幕| 人人人妻人人澡人人爽欧美一区| 无码任你躁久久久久久久| а√天堂www在线а√天堂资源| 亚洲色欲色欲综合网站| 加勒比无码一区二区三区| 天天干天天日| 亚洲精品国产一区二区精华| 少妇人妻偷人精品无码视频新浪| 青青草国产成人99久久| 国产精品三级国产电影| 人人妻人人爽人人添夜夜欢视频| 成av人片一区二区三区久久| 风流老熟女一区二区三区| 亚洲高清专区日韩精品| 久久精品国产精品亚洲蜜月| 好爽…又高潮了毛片免费看| 成人看的污污超级黄网站免费| 潮喷大喷水系列无码久久精品| av无码av天天av天天爽| 少妇熟女视频一区二区三区| 国产精品a国产精品a手机版| 久久青青草免费线频观| 国产乱人伦app精品久久| 日本精品αv中文字幕| 国产av亚洲精品久久久久久小说 | 亚洲一区精品无码色成人| 色插图午夜影院| 久久精品亚洲一区二区三区浴池| 国产系列丝袜熟女精品网站| 久久久精品人妻无码专区不卡| 国产永久免费观看视频| 精品一区二区三区国产在线观看 | 日本韩国亚洲欧美在线 |