在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ITGA8 Antibody, HRP conjugated

ITGA8 Antibody, HRP conjugated

  • 中文名稱：
    ITGA8兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA011871NB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ITGA8 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    Integrin alpha 8 antibody; Integrin alpha-8 heavy chain antibody; Integrin alpha-8 light chain antibody; ITA8_HUMAN antibody; ITGA 8 antibody; ITGA8 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Peptide sequence from Human Integrin alpha-8 protein (114-131AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.
  • 基因功能參考文獻：
    1. ITGA2B and ITGA8 have roles in prognosis in clear cell renal cell carcinoma patients PMID: 26198048
    2. In 15 of 590 families, we identified recessive mutations in the genes FRAS1, FREM2, GRIP1, FREM1, ITGA8, and GREM1, all of which function in the interaction of the ureteric bud and the metanephric mesenchyme. PMID: 24700879
    3. Mutations of ITGA8 are a genetic cause of bilateral renal agenesis and that, at least in some cases, bilateral renal agenesis is an autosomal-recessive disease. PMID: 24439109
    4. the ITGA8 gene might have gender-specific roles in the development of schizophrenia. PMID: 23153507
    5. Analysis of the data demonstrated that Itga8 expression is CArG box-serum response factor independent, but myocardin dependent through an as yet unknown sequence module that is distal from the promoter region. PMID: 23142384
    6. The mRNA levels of Integrinalpha8 were significantly lower in LSCC tissues than that in corresponding adjacent normal tissues. PMID: 20942236
    7. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance. PMID: 20678483
    8. expressed in developing kidney PMID: 12060755
    9. Role in regulation of mesangial cell phenotype. Seems to promote adhesion, but inhibit migration and proliferation of mesangial cells. Alpha8 integrin could play important role in maintaining tissue integrity in glomerulus during glomerular injury. PMID: 12787402
    10. genomic analysis of the human integrin subunit alpha8 gene PMID: 15579315
    11. Mammary carcinoma cells do express alpha8 integrin. PMID: 15592496
    12. A polymorphism of the ITGA8 promoter modifies the progression of renal failure in ADPKD. PMID: 18277079
    13. These results indicate that the specific high-affinity binding of nephronectin to alpha8beta1 integrin is achieved by bipartite interaction of the integrin with the RGD motif and LFEIFEIER sequence. PMID: 19342381
    14. In intestinal crypt cells, integrin alpha8beta1 is closely involved in the regulation of adhesion, migration and cell proliferation via a predominant RhoA/ROCK-dependent mechanism. PMID: 19527220

    顯示更多

    收起更多

  • 相關疾病：
    Renal hypodysplasia/aplasia 1 (RHDA1)
  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein. Cell membrane.
  • 蛋白家族：
    Integrin alpha chain family
  • 組織特異性：
    Expressed in mesenchymal cells, including alveolar myofibroblasts, kidney mesangial cells and hepatic stellar cells and vascular and visceral smooth muscle (at protein level).
  • 數據庫鏈接：

    HGNC: 6144

    OMIM: 191830

    KEGG: hsa:8516

    STRING: 9606.ENSP00000367316

    UniGene: Hs.171311



主站蜘蛛池模板： 日韩人妻熟女中文字幕aⅴ春菜| 最近中文字幕免费mv在线| 精品国产乱码久久久久久下载| 狠狠色噜噜狠狠狠狠米奇777| 又粗又黄又爽视频免费看| 国产精品无码永久免费888| 国产裸体xxxx视频| 国产国语亲子伦亲子| 日韩精品一区二区在线观看| 精品一区二区三区东京热| 国产自愉自愉免费精品七区| av无码动漫一区二区三区精品| 亚洲精品午夜一区二区电影院| 中国白嫩丰满人妻videos| 欧美乱妇高清无乱码| 精品国产乱码久久久人妻| 久久婷婷综合激情亚洲狠狠| 午夜无码性爽快影院6080| 日产精品一二三区| 妺妺窝人体色www聚色窝| 国产精品熟女高潮视频| 亚洲一区在线日韩在线秋葵| 中文字幕精品久久久久人妻红杏| 国产日韩在线视看第一页| 色综合久久蜜芽国产精品| 亚洲综合av色婷婷| 偷自拍亚洲视频在线观看99 | 久久香蕉国产线看观看手机| 国产又色又爽又黄的视频在线观看| 99e热久久免费精品首页| 人人妻人人澡人人爽不卡视频 | 午夜精品久久久久久久久| 国产在线高清理伦片a| 日本高清不卡aⅴ免费网站| 日韩内射美女人妻一区二区三区| 国产不卡视频一区二区三区| 在线观看黄a∨免费无毒网站| 欧美精品videossex另类日本| 边喂奶边中出的人妻| 中文字幕日本六区小电影| 国产av夜夜欢一区二区三区|