在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ITGA7 Antibody, FITC conjugated

  • 中文名稱:
    ITGA7兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA618797LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) ITGA7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    alpha 7 antibody; FLJ25220 antibody; Integrin alpha 7 antibody; Integrin alpha 7 chain antibody; Integrin alpha 7 heavy chain antibody; Integrin alpha 7 light chain antibody; Integrin alpha-7 70 kDa form antibody; ITA7_HUMAN antibody; ITGA 7 antibody; Itga7 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Integrin alpha-7 protein (175-283AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
  • 基因功能參考文獻:
    1. Speculate that the postnatal splicing of alpha7A to alpha7B and of beta1A to beta1D integrins is delayed, altering spontaneous descent of the testes in the first months of life. PMID: 30089289
    2. As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. PMID: 27924820
    3. targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. PMID: 28602620
    4. Taken together, these results further support the use of a7 integrin as a potential therapy for Duchenne muscular dystrophy PMID: 26076707
    5. Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. PMID: 26320193
    6. Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. PMID: 26011651
    7. ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells. PMID: 23830872
    8. The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. PMID: 24227711
    9. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7] PMID: 23800289
    10. Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury. PMID: 24091324
    11. This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. PMID: 20651226
    12. ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression. PMID: 20460506
    13. conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology PMID: 12057917
    14. FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells PMID: 15117962
    15. alpha7-expressing fetal myoblasts are capable of differentiation to osteoblast lineage with a coordinated switch in integrin profiles and may represent a mechanism that promotes homing and recruitment of myogenic stem cells for tissue remodeling. PMID: 17054947
    16. Integrin alpha7 mutations are associated with prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma PMID: 17551147
    17. analysis of how distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms PMID: 17618648
    18. Alpha7B is a novel marker of the contractile phenotype, and alpha7 expression is essential for human airway smooth muscle cell maturation, which is a laminin-dependent process. PMID: 17641293
    19. cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions. PMID: 18940796
    20. laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts PMID: 19416897

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Integrin alpha chain family
  • 組織特異性:
    Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes
  • 數(shù)據(jù)庫鏈接:

    HGNC: 6143

    OMIM: 600536

    KEGG: hsa:3679

    STRING: 9606.ENSP00000452120

    UniGene: Hs.524484



主站蜘蛛池模板: 久久人午夜亚洲精品无码区| 国产人妻黑人一区二区三区| 新国产精品视频福利免费| 无码人妻精品一区二区三区久久| 午夜亚洲影院在线观看| 国产v亚洲v天堂无码| 人妻无码人妻有码中文字幕| 刺激一区仑乱| 亚洲欧美日本久久综合网站| 国产偷窥熟精品视频| 熟女人妻av完整一区二区三区| 久久精品无码精品免费专区| 日本免费人成视频播放| 欧美乱大交aaaa片if| 强行从后面挺进人妻| 日日碰狠狠添天天爽| 亚洲精品一区国产| 国产免费爽爽视频在线观看| 亚洲欧美日韩综合av| 亚洲精品一区三区三区在线观看| 在线看片免费人成视频久网| 东京热一精品无码av| 国产成人一区二区三区免费视频| 日本在线视频www色| 麻豆精产国品| 四虎永久免费地址入口| 久久国产精品老女人| 东京热无码av男人的天堂| 亚洲第一成人网站在线播放| 风韵犹存丰满大屁股熟妇视频| 欧洲精品一线二线三线区别| 免费中文字幕日韩欧美| 一本大道一卡2卡三卡4卡国产| 中文字幕一区二区三区久久网站 | 精精国产xxxx视频在线| 狠狠色噜噜狠狠狠狠97首创麻豆| 欧美乱码伦视频免费| 99精品视频免费热播在线观看| 爱做久久久久久| 国产真实伦在线观看视频| 精品亚洲aⅴ在线无码播放|