在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IST1 Antibody

IST1 Antibody

  • 中文名稱：
    IST1兔多克隆抗體
  • 貨號：
    CSB-PA012171GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    hIST1 antibody; Increased sodium tolerance 1 antibody; Increased sodium tolerance 1 homolog antibody; IST1 homolog antibody; IST1_HUMAN antibody; KIAA0174 antibody; MAPK activating protein PM28 antibody; MGC117220 antibody; MGC128433 antibody; Putative MAPK-activating protein PM28 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Human OLC1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    ESCRT-III-like protein involved in specific functions of the ESCRT machinery. Is required for efficient abscission during cytokinesis, but not for HIV-1 budding. The involvement in the MVB pathway is not established. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
  • 基因功能參考文獻(xiàn)：
    1. Nuclear overexpression of OLC1 was associated with clinicopathological parameters and could predict a poor overall survival in gastric adenocarcinoma. PMID: 28038462
    2. The expression of OLC1 in the tumor tissues of lung adenocarcinoma is higher than that in squamous cell carcinoma. PMID: 28532543
    3. Structural and biochemical studies reveal an unusually tight interaction between ULK3 and IST1, an ESCRT-III subunit required for cytokinetic abscission. PMID: 26011858
    4. Overexpression of OLC1 promotes tumorigenesis of human esophageal squamous cell carcinoma. PMID: 24608342
    5. Findings indicate that a high expression level of overexpressed in lung cancer 1 (OLC1) serves as a biomarker for poor prognosis for breast cancer, suggesting that OLC1 may be a potential target of antiangiogenic therapy for breast cancer. PMID: 24880589
    6. Over-expression of the OCL1 is associated with colorectal cancer. PMID: 24403489
    7. the binding of ALG-2 to IST1 is Ca(2+)-dependent PMID: 23649269
    8. The results suggest that inclusion of IST1 into the ESCRT complex allows recruitment of spastin to promote fission of recycling tubules from the endosome. PMID: 23897888
    9. OLC1 over-expression is an important factor in epithelial ovarian carcinoma prognosis and can be a potential biomarker for ovarian carcinoma. PMID: 23609236
    10. The interaction between CL7MIT and CHMP1B and between CL7MIT and IST1 became stronger when IST1 or CHMP1B was additionally coexpressed, suggesting formation of ternary complex of calpain-7, IST1 and CHMP1B. PMID: 21616915
    11. These results demonstrate that cigarette smoke regulates OLC1 expression in lung cancer cells by compromising its ubiquitination and subsequent degradation through the ubiquitin E3 ligase APC. PMID: 21439932
    12. These data suggest that Ist1 interaction is important for spartin recruitment to the midbody and that spartin participates in cytokinesis. PMID: 20719964
    13. Results demonstrate that human calpain 7 is proteolytically active, and imply that calpain 7 is activated by ESCRT-III-related protein IST1. PMID: 20849418
    14. OLC1 (KIAA0174) is a candidate oncogene in lung cancer whose expression may be regulated by exposure to cigarette smoke. PMID: 19001599
    15. IST1 and CHMP1 act together to recruit and modulate specific VPS4 activities required during the final stages of cell division. PMID: 19129479
    16. hIST1 is essential for cytokinesis in mammalian cells. PMID: 19129480
    17. Data show that the N-terminal core domains of increased sodium tolerance-1 (IST1) and charged multivesicular body protein-3 (CHMP3) form equivalent four-helix bundles, revealing that IST1 is a previously unrecognized ESCRT-III family member. PMID: 19525971

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasmic vesicle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Nucleus envelope.
  • 蛋白家族：
    IST1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 28977

    OMIM: 616434

    KEGG: hsa:9798

    STRING: 9606.ENSP00000330408

    UniGene: Hs.232194



主站蜘蛛池模板： 无码帝国www无码专区色综合| 久久免费的精品国产v∧| 国产精品岛国久久久久| 国产亚洲精品久久久久动漫| 日本护士xxxxhd少妇| 日本一区午夜艳熟免费| 精品国产三级在线观看| 国产日产欧产精品精品| 成 人 a v免费视频在线观看| 欧美激欧美啪啪片| 日本va欧美va精品发布| 人妻无码中文字幕| 熟女俱乐部五十路六十路| 一本无码人妻在中文字幕| 可以直接看的无码av| 亚洲 日韩 国产 中文有码| 国产成人欧美日韩在线电影 | 国产在视频线精品视频| 久久久精品久久久久久96| 免费无码在线播放av| 老熟女重囗味hdxx70星空| 一本色道久久88综合日韩精品| 日本两人免费观看的视频| 亚洲国产精品无码中文lv| 久久久久波多野结衣高潮| 欧美黑人粗大xxxxbbbb| 午夜男女无遮掩免费视频| 中文字幕人成人乱码亚洲电影 | 又爆又大又粗又硬又黄的a片| 欧美精品色婷婷五月综合| 一 级做人爱全视频在线看| 蜜桃av久久久一区二区三区麻豆| 亚洲国产成人精品无码区在线观看 | 国产精品_九九99久久精品| 无码午夜福利片| 亚洲色成人网站www永久四虎| 少妇白浆呻吟爽| 国色天香社区在线视频| 天天躁日日躁狠狠躁欧美老妇小说| 欧美日韩无套内射另类 | 亚洲线精品一区二区三区影音先锋 |