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  4. IRF2BP1 Antibody

IRF2BP1 Antibody

  • 中文名稱：
    IRF2BP1兔多克隆抗體
  • 貨號：
    CSB-PA815541LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA815541LA01HU diluted at 1:100 and staining in paraffin-embedded human salivary gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of Hela cells with CSB-PA815541LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IRF2BP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IRF2BP1
  • 別名：
    DKFZp434M154 antibody; I2BP1_HUMAN antibody; Interferon regulatory factor 2 binding protein 1 antibody; Interferon regulatory factor 2-binding protein 1 antibody; IRF 2BP1 antibody; IRF-2-binding protein 1 antibody; IRF-2BP1 antibody; IRF2 binding protein 1 antibody; Irf2bp1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Interferon regulatory factor 2-binding protein 1 protein (340-499AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，IRF2BP1 Antibody (CSB-PA815541LA01HU)，的標記方式是Non-conjugated。對于IRF2BP1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA815541LB01HU IRF2BP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA815541LC01HU IRF2BP1 Antibody, FITC conjugated
    Biotin CSB-PA815541LD01HU IRF2BP1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation.
  • 基因功能參考文獻：
    1. Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2. PMID: 12799427
    2. PCTA (IRF2BP1) defines a new component of the TGF-beta signalling pathway that functions to facilitate Smad2 phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2-receptor complex. PMID: 18511908
    3. IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter. PMID: 18671972
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    IRF2BP family
  • 數據庫鏈接：

    HGNC: 21728

    OMIM: 615331

    KEGG: hsa:26145

    STRING: 9606.ENSP00000307265

    UniGene: Hs.515477



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