在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IRF2 Antibody

  • 中文名稱:
    IRF2兔多克隆抗體
  • 貨號:
    CSB-PA011815ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human thyroid tissue using CSB-PA011815ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA011815ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA011815ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IRF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    IRF2
  • 別名:
    DKFZp686F0244 antibody; Interferon regulatory factor 2 antibody; IRF 2 antibody; IRF-2 antibody; IRF2 antibody; IRF2_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interferon regulatory factor 2 protein (120-349AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and represses those genes. Also acts as an activator for several genes including H4 and IL7. Constitutively binds to the ISRE promoter to activate IL7. Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth. Antagonizes IRF1 transcriptional activation.
  • 基因功能參考文獻:
    1. Data suggest that MIR1290 expression is remarkably upregulated in non-small-cell lung carcinoma tissues compared to adjacent normal lung tissues; IRF2 appears to be a direct target of MIR1290. (MIR1290 = microRNA-1290; IRF2 = interferon regulatory factor-2) PMID: 29275213
    2. These finding suggests that miR-302b inhibits key transcription factors and cytokines by targeting ERBB4, IRF2 and CXCR4, implicating its role in the inhibition of CRI in EC. PMID: 28467773
    3. Our study primarily suggests IRF-2 as a potential prognostic biomarker in colorectal cancer PMID: 28465494
    4. The effects of IRF2 suppresses non-small cell lung cancer by promoting cell apoptosis, inhibiting cell proliferation and migration ability. PMID: 28471447
    5. In a genome wide are study to identify acute kidney injury risk in critically ill patients, the locus on chromosome 4, located 150 kb upstream of IRF2 was identified to regulate immunity pathways related to kidney disease risk gene APOL1. Disruption of IRF-2 has been found to up-regulate the inflammatory response to infection. PMID: 27576016
    6. Study shows that IRF2 knockdown inhibits growth, colony formation of OCI/AML-2, OCI/AML-3, and THP-1 cells. In addition, IRF2 knockdown induces apoptosis of acute myeloid leukemia (AML) cells by regulating apoptotic effectors. Further mechanism analysis shows that INPP4B contributes to the effects of IRF2 on apoptosis and growth of AML cells. Thus, IRF2 serves as an important regulator in AML by targeting INPP4B. PMID: 28579269
    7. miR-450 targets IRF2 and thus supresses lung cancer cell proliferation and invasion. PMID: 27246609
    8. It might play as a tumor suppressor by regulating P53 signaling in gastric cancer. PMID: 26173586
    9. the association of IRF2 with susceptibility to systemic lupus erythematosus PMID: 25285625
    10. IRF2genes were not associated with pancreatitis. 4 variants were found: c.123G>A (novel), c.651C>T, c.744G>A, and c.638C>T, p.P213L. PMID: 25207663
    11. miR-221 directly inhibits the expression of SOCS3 and IRF2. PMID: 24607843
    12. IFN regulatory factor 2 (Irf2) has a regulatory role in trypsinogen5 gene transcription, which is resistant to a major endogenous trypsin inhibitor, Spink3 PMID: 22042864
    13. IRF2 overexpression protects against I/R injury by decreasing IRF1-dependent injury and may represent a novel therapeutic strategy. PMID: 22744333
    14. The results suggested that distinct markers in IRF2 may be associated with atopic dermatitis and eczema herpeticum (which may depend upon ethnic ancestry) and genetic variants in IRF2 may contribute to an abnormal immune response to herpes simplex virus. PMID: 22113474
    15. these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer. PMID: 22119988
    16. IRF-2 activates the HPV-16 P97 promoter in vivo. PMID: 20129639
    17. IRF-2 activates RIG-I promoter through ISRE-like site as well as IRF-1 and IFN-alpha stimulation. PMID: 20034464
    18. PTB binding to multiple sites within IRF2 5'UTR leads to a conformational change in the RNA that facilitate binding of other trans-acting factors to mediate internal initiation of translation PMID: 19756143
    19. IRF2 is a potential susceptibility gene for psoriasis. PMID: 14962090
    20. IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression in cell differentiation PMID: 15496418
    21. In cells transfected with both IRF-2 and p300/CBP-associated factor , IRF-2 associated with endogenous nucleolin. PMID: 16582966
    22. IRF8 cooperates with PU.1 and IRF-2 to activate a composite ets/IRF-cis element in the NF1 promoter. The conserved IRF domain tyrosine in ICSBP/IRF8 is required for interaction with the DNA-bound PU.1-IRF2 heterodimer. PMID: 17200120
    23. IRF-2 regulates NF-kappaB activity via the modulation of NF-kappaB subcellular localization. PMID: 18395009
    24. IRF2 interacts with the SUMO-E3 ligase PIASy and is sumoylated in vivo PMID: 18514056

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    IRF family
  • 組織特異性:
    Expressed throughout the epithelium of the colon. Also expressed in lamina propria.
  • 數據庫鏈接:

    HGNC: 6117

    OMIM: 147576

    KEGG: hsa:3660

    STRING: 9606.ENSP00000377218

    UniGene: Hs.654566



主站蜘蛛池模板: 真人无码作爱免费视频| 中文午夜乱理片无码| 国产老熟女老女人老人| 伊人精品无码av一区二区三区| 国产精品久久久久影院老司| 亚洲精品www久久久久久| 亚洲精品久久久久久成人| 伊人狼人大焦香久久网| 50岁熟妇大白屁股真爽| 成年无码av片在线| 国产亚洲精品久久久久5区| 蜜臀性色av免费| 国产在线不卡精品网站| 中文在线8资源库| 成人精品一区日本无码网站 | 无套内射chinesehd熟女| 亚洲国产欧美在线人成最新| 中文区中文字幕免费看| 天天综合亚洲色在线精品| 久久99日韩国产精品久久99| 亚洲图片小说激情综合| 大陆国语对白国产av片| 无遮挡国产高潮视频免费观看| 国产福利萌白酱精品tv一区| 色琪琪丁香婷婷综合久久| 99久久99久久精品免费看蜜桃| 欧美国产日产一区二区| 国产免费人成在线视频app| 国产乱子伦精品无码码专区| 97精品久久久久中文字幕| 欧美成va视频网站| 在线观看的av免费网站| 国产乱妇无码大片在线观看 | 国产精品一区二区av| 成人性三级欧美在线观看| 日韩人妻无码一区二区三区俄罗斯| 女人被狂躁的高潮免费视频| 好爽毛片一区二区三区四| 国产成人亚洲高清一区| 无码av最新高清无码专区| 大肉大捧一进一出好爽视频|