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IP6K1 Antibody, FITC conjugated

  • 中文名稱:
    IP6K1兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA011770LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) IP6K1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ATP:1D myo inositol hexakisphosphate phosphotransferase antibody; IHPK1 antibody; Inositol hexakisphosphate kinase 1 antibody; Inositol hexaphosphate kinase 1 antibody; InsP6 antibody; InsP6 kinase 1 antibody; Ip6k1 antibody; IP6K1_HUMAN antibody; Itpk6 antibody; Pi uptake stimulator antibody; PiUS antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Inositol hexakisphosphate kinase 1 protein (1-441AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4.
  • 基因功能參考文獻:
    1. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate. PMID: 28154132
    2. provides the first evidence for the involvement of IP6Ks in dynein function and proposes that inositol pyrophosphate-mediated pyrophosphorylation may act as a regulatory signal to enhance dynein-driven transport PMID: 27474409
    3. IP6K1 is also involved in early cytoskeleton remodeling events during cancer progression. PMID: 27140681
    4. IP6K1 is a novel CRL4 subunit that transduces UV signals to mediate disassembly of the CRL4-CSN complex, thereby regulating nucleotide excision repair and cell death. PMID: 25349427
    5. we identified IP6Ks as novel nuclear and cytosolic InsP6- (and InsP5-) dephosphorylating enzymes whose activity is sensitively driven by a decrease in the cellular ATP/ADP ratio PMID: 24865181
    6. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
    7. IHPK1 gene is disrupted at the 3p21.31 breakpoint of t(3;9) in a family with type 2 diabetes mellitus PMID: 15221640
    8. Results report the characterization of an inhibitor, N(2)-(m-(trifluoromethy)lbenzyl) N(6)-(p-nitrobenzyl)purine (TNP), selective for inositol hexakisphosphate kinases. PMID: 19208622

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  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Inositol phosphokinase (IPK) family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18360

    OMIM: 606991

    KEGG: hsa:9807

    STRING: 9606.ENSP00000323780

    UniGene: Hs.386168



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