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  4. INVS Antibody

INVS Antibody

  • 中文名稱：
    INVS兔多克隆抗體
  • 貨號：
    CSB-PA011769LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: INVS antibody IgG at 14μg/ml + K562 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 118, 100, 11 kDa
      Observed band size: 118 kDa
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA011769LA01HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA011769LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) INVS Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    INVS antibody; INV antibody; NPHP2 antibody; Inversin antibody; Inversion of embryo turning homolog antibody; Nephrocystin-2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Inversin protein (1-101AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，INVS Antibody (CSB-PA011769LA01HU)，的標記方式是Non-conjugated。對于INVS Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA011769LB01HU INVS Antibody, HRP conjugated ELISA
    FITC CSB-PA011769LC01HU INVS Antibody, FITC conjugated
    Biotin CSB-PA011769LD01HU INVS Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis.
  • 基因功能參考文獻：
    1. Collectively, these results indicated that inversin might promote the tumorigenicity of lung cancer cells and serve as a novel therapeutic target of non-small cell lung cancer. PMID: 28618971
    2. Akt phosphorylates inversin at amino acids 864-866 that are required not only for Akt interaction, but also for inversin dimerization. PMID: 27220846
    3. Truncating mutations in NPHP2 gene is associated with nephronophthisis-related ciliopathy. PMID: 23559409
    4. INVS mutation can cause juvenile nephronophthisis with abnormal reactivity of the Wnt/beta-catenin pathway. PMID: 20798123
    5. has conserved ankyrin repeat and IQ domains and interacts with calmodulin PMID: 11941489
    6. analysis of a homozygous mutation in exon 13 of inversin (INVS) (C2719T, R907X) in a patient with retinitis pigmentosa and renal failure [case report] PMID: 16522655
    7. Thus, although considered a common variant, inv(10)(p11.2q21.2) has a single ancestral founder among northern Europeans. PMID: 16642442
    8. new mutant genes might be responsible for the early onset of ESRD in infantile NPHP with features of JBTS PMID: 17216245
    9. Cystic kidney disease has been linked to mutations in the Invs gene in mice with an inversion of embryonic turning (inv/inv) and the INVS (NPHP2) gene in human infantile nephronophthisis (NPH). PMID: 18218308

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  • 相關疾病：
    Nephronophthisis 2 (NPHP2)
  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Membrane; Peripheral membrane protein. Nucleus. Cell projection, cilium. Note=Associates with several components of the cytoskeleton including ciliary, random and polarized microtubules. During mitosis, it is recruited to mitotic spindle. Frequently membrane-associated, membrane localization is dependent upon cell-cell contacts and is redistributed when cell adhesion is disrupted after incubation of the cell monolayer with low-calcium/EGTA medium.
  • 組織特異性：
    Widely expressed. Strongly expressed in the primary cilia of renal tubular cells.
  • 數據庫鏈接：

    HGNC: 17870

    OMIM: 243305

    KEGG: hsa:27130

    STRING: 9606.ENSP00000262457

    UniGene: Hs.558477



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