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  4. INTS6 Antibody, Biotin conjugated

INTS6 Antibody, Biotin conjugated

  • 中文名稱：
    INTS6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA011764LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) INTS6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    INTS6
  • 別名：
    DBI 1 antibody; DBI-1 antibody; DBI1 antibody; DDX26 antibody; DDX26A antibody; DEAD box protein antibody; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 26 antibody; Deleted in cancer 1 antibody; DICE1 antibody; DKFZp434B105 antibody; HDB antibody; Int6 antibody; INT6_HUMAN antibody; Integrator complex subunit 6 antibody; INTS 6 antibody; ints6 antibody; Notchl2 antibody; OTTHUMP00000018439 antibody; OTTHUMP00000215034 antibody; OTTHUMP00000215036 antibody; Protein DDX26 antibody; Protein deleted in cancer 1 antibody; RNA helicase HDB antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Integrator complex subunit 6 protein (571-795AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex. May have a tumor suppressor role; an ectopic expression suppressing tumor cell growth.
  • 基因功能參考文獻：
    1. DICE1 appears to be involved in prostate cancer progression rather than in the initiation of prostate cancer. PMID: 25660097
    2. Findings demonstrate INTS6P1 and INTS6 exert the tumor suppressive roles through competing for oncomiR-17-5p. PMID: 25686840
    3. In response to the DNA damage response, INTS3-hSSB1-INTS6 complex relocates to the DNA damage sites. PMID: 23986477
    4. Findings suggest that EBV encoded miR-BART3* miRNA targets DICE1 tumor suppressor to promote cellular growth and transformation in nasopharyngeal cancer(NPC). PMID: 23280823
    5. Molecular characterization of the tumor suppressor gene in lung carcinoma cells PMID: 11939413
    6. Somatic mutations were identified in three patients (3/56, 5%), and one novel polymorphism was identified in 3% of ESCC patients (4/136) and 3% of healthy individuals (6/232). We conclude that DICE1 mutations occur in ESCC but are infrequent. PMID: 12527901
    7. DICE1 has a growth-suppressing activity and interferes with anchorage-independent growth of IGF-IR transformed tumor cells dependent upon IGF-I signaling PMID: 15254679
    8. Not mutated in human cancer cell lines which demonstratse 13q14 deletions. PMID: 16271964

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Integrator subunit 6 family
  • 組織特異性：
    Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
  • 數據庫鏈接：

    HGNC: 14879

    OMIM: 604331

    KEGG: hsa:26512

    STRING: 9606.ENSP00000310260

    UniGene: Hs.439440



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