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  4. INPP5K Antibody

INPP5K Antibody

  • 中文名稱：
    INPP5K兔多克隆抗體
  • 貨號(hào)：
    CSB-PA866277ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA866277ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) INPP5K Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    43 kDa form skeletal muscle and kidney enriched inositol phosphatase antibody; Inositol polyphosphate 5-phosphatase K antibody; INP5K_HUMAN antibody; INPP5K antibody; muscle and kidney-enriched inositol phosphatase antibody; PPS antibody; skeletal muscle and kidney enriched inositol phosphatase antibody; Skeletal muscle and kidney-enriched inositol phosphatase antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Inositol polyphosphate 5-phosphatase K protein (149-448AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate. Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle.
  • 基因功能參考文獻(xiàn)：
    1. the distribution of genotype frequency exhibited no significant differences between the Parkinson's disease and control groups (P > 0.025) in INPP5K rs1109303 (P = 0.048, OR = 0.806, 95%CI = 0.650 - 0.998). PMID: 29607885
    2. In individuals exhibiting congenital muscular dystrophy, early-onset cataracts, and mild intellectual disability but normal cranial magnetic resonance imaging, we identified bi-allelic mutations in INPP5K, encoding inositol polyphosphate-5-phosphatase K. PMID: 28190456
    3. Mutations in INPP5K cause a congenital muscular dystrophy syndrome with short stature, cataracts, and intellectual disability. PMID: 28190459
    4. These findings suggest a model by which GRP78 regulates intracellular localization of SKIP and how SKIP binds to Pak1 on insulin stimulation. PMID: 26940976
    5. Study reveals that SKIP is a significant regulator of glioblastoma cell migration and that increased expression of SKIP may confer a survival advantage. PMID: 25241900
    6. SKIP controls the IGF-II-PI 3-kinase-Akt-mTOR auto-regulation loop during myogenesis. PMID: 22815484
    7. Specific suppression of insulin signaling is achieved via the spatiotemporal regulation of SKIP through the scaffolding function of Pak1. PMID: 22751929
    8. identification of novel domain that mediates membrane ruffle localization PMID: 12536145
    9. The authors report that HBV core protein interacts with a cellular SKIP (skeletal muscle and kidney enriched inositol phosphatase) protein, an endoplasmic reticulum-located phosphoinositide 5-phosphatase, both in vivo and in vitro. PMID: 18774950

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  • 相關(guān)疾病：
    Muscular dystrophy, congenital, with cataracts and intellectual disability (MDCCAID)
  • 亞細(xì)胞定位：
    Endoplasmic reticulum. Cytoplasm.
  • 蛋白家族：
    Inositol 1,4,5-trisphosphate 5-phosphatase type II family
  • 組織特異性：
    Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 33882

    OMIM: 607875

    KEGG: hsa:51763

    STRING: 9606.ENSP00000413937

    UniGene: Hs.632238



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