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Your Good Partner in Biology Research

ING5 Antibody

  • 中文名稱:
    ING5兔多克隆抗體
  • 貨號:
    CSB-PA011716GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ING5
  • 別名:
    1700001C14Rik antibody; 1700027H23Rik antibody; 1810018M11Rik antibody; FLJ23842 antibody; ING 5 antibody; Ing5 antibody; ING5_HUMAN antibody; Inhibitor of growth family member 5 antibody; Inhibitor of growth protein 5 antibody; p28 ING 5 antibody; p28 ING5 antibody; p28ING5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human ING5
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator. Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner.
  • 基因功能參考文獻:
    1. our results demonstrate, for the first time that overexpression of ING5 in osteosarcoma cells induces apoptosis PMID: 29528777
    2. ING5 promotes brain tumor initiating cells stemness by maintaining intracellular calcium levels and activating the follicle stimulating hormone pathway. PMID: 28925404
    3. Nucleocytoplasmic translocation of ING5 protein occurs in breast cancer, and the high expression of nuclear ING5 is inversely related to some poor clinicopathological behaviors of breast cancer. PMID: 29595458
    4. Overexpression of ING5 inhibited cell proliferation, neoplasm invasion and epithelial-mesenchymal transition of thyroid cancer cells. PMID: 29272787
    5. We revealed that miR-24 had the opposite effects to those of ING5 on breast cancer cells and could accelerate xenografted tumor growth in vivo. Our findings uncover the tumor-suppressive role of ING5 and the regulatory pathway of ING5 in breast cancer and may provide insights into the molecular mechanisms of breast carcinogenesis PMID: 28490335
    6. ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-kappaB/MMP-9 signaling pathway. PMID: 29326045
    7. Data suggest that inhibitor of growth protein 5 (ING5) downregulation might involved in carcinogenesis, growth, and invasion of lung cancer and could be considered as a promising marker to gauge the aggressiveness of lung cancer. PMID: 27409347
    8. miR-1307 could promote ovarian cancer chemoresistance by targeting the ING5 expression and miR-1307 might serve as a therapeutic target for ovarian cancer. PMID: 28086946
    9. miR-331-3p is upregulated by HBV and promotes proliferation of hepatocellular carcinoma cells though repression of ING5 expression. PMID: 26497554
    10. Suggest that ING5 expression might be a good marker for gastric carcinogenesis and its subsequent progression by inhibiting proliferation, growth, migration, invasion and metastasis. PMID: 25980581
    11. Loss of ING5 expression is associated with lung cancer. PMID: 25938545
    12. Identified ING5 as a novel CDK2 substrate. ING5 is phosphorylated at a single site, threonine 152, by cyclin E/CDK2 and cyclin A/CDK2. This site is also phosphorylated in cells in a cell cycle dependent manner, consistent with it being a CDK2 substrate. PMID: 25860957
    13. Results showed that ING5 gene expression is inhibited by miR-193a-3p and is instrumental in miR-193a-3p's role in activating BCa chemoresistance. PMID: 25991669
    14. Data indicate that ING5 associates with Tip60 (KAT5) to form a complex with p53. PMID: 23576563
    15. ING5 down-regulation promotes bone mesenchymal stem cell proliferation. PMID: 22384930
    16. Results indicate that ING5 is a growth suppressor with suppressed expression in AML whose functions depend on its interaction with INCA1. PMID: 21750715
    17. EBNA3C negatively regulate p53-mediated functions by interacting with ING4 and ING5. PMID: 21177815
    18. Aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas. PMID: 21193223
    19. ). Survival analysis indicated that nuclear ING5 was closely linked to favorable prognosis of carcinoma patients (P < .05), albeit not independent. PMID: 21062663
    20. Our study indicates for the first time, that oncogenic ras and loss of Smad signaling cooperate to upregulate EGFR and erbB2, which plays a role in promoting invasion. PMID: 20131318
    21. ING5 may function as a tumor suppressor gene or oncogene tightly linked with p53 status, and may play an important role in the prognosis of head and neck squamous cell carcinoma (HNSCC) patients. PMID: 20182888
    22. Tumor-specific mutation and down-regulation of ING5 mRNA suggested it as a tumor suppressor gene in oral squamous cell carcinoma PMID: 20131318
    23. p29ING4 and p28ING5 may be significant modulators of p53 function. PMID: 12750254
    24. the PHD domain of ING5 has the characteristic tertiary fold of a zinc finger. PMID: 18623064

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  • 亞細胞定位:
    Nucleus. Chromosome.
  • 蛋白家族:
    ING family
  • 組織特異性:
    Down-regulated in bone marrow cells in acute myeloid leukemia patients as compared with normal bone marrow cells.
  • 數據庫鏈接:

    HGNC: 19421

    OMIM: 608525

    KEGG: hsa:84289

    STRING: 9606.ENSP00000322142

    UniGene: Hs.529172



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