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  4. ILKAP Antibody, HRP conjugated

ILKAP Antibody, HRP conjugated

  • 中文名稱：
    ILKAP兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA011686HB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) ILKAP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ILKAP
  • 別名：
    DKFZp434J2031 antibody; FLJ10181 antibody; ILKAP antibody; ILKAP_HUMAN antibody; ILKAP2 antibody; ILKAP3 antibody; Integrin linked kinase associated phosphatase antibody; Integrin linked kinase associated serine/threonine phosphatase 2C antibody; Integrin linked kinase associated serine/threonine phosphatase antibody; Integrin-linked kinase-associated serine/threonine phosphatase 2C antibody; MGC4846 antibody; PP2C DELTA antibody; Protein phosphatase 2c delta isozyme antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Integrin-linked kinase-associated serine/threonine phosphatase 2C protein (1-392AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.
  • 基因功能參考文獻：
    1. ILKAP physically interacted with HIF-1A and induced its dephosphorylation. Both the HIF-1A-p53 interaction and apoptosis relied on ILKAP. PMID: 29742494
    2. our data suggest an essential role of PINCH1, ILK and ILKAP for the radioresistance of p53-wildtype glioblastoma multiforme cells PMID: 26460618
    3. The expression of ILKAP was considerably lower in eutopic and ectopic endometrial samples from women with endometriosis than in control endometrium. Expression varied depending on the phase of the menstrual cycle. PMID: 25872452
    4. Data show involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma PMID: 24743186
    5. ILKAP is a nuclear protein that regulates cell survival and apoptosis through the regulation of RSK2 signaling. PMID: 23329845
    6. these results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. PMID: 21782789

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    PP2C family
  • 組織特異性：
    Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.
  • 數據庫鏈接：

    HGNC: 15566

    KEGG: hsa:80895

    STRING: 9606.ENSP00000254654

    UniGene: Hs.92033



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