在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ILF3 Antibody

  • 中文名稱:
    ILF3兔多克隆抗體
  • 貨號:
    CSB-PA011684GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    ILF3
  • 別名:
    CBTF antibody; Double stranded RNA binding protein 76 antibody; Double-stranded RNA-binding protein 76 antibody; DRBF antibody; DRBP76 antibody; ILF3 antibody; ILF3_HUMAN antibody; Interleukin enhancer binding factor 3 antibody; Interleukin enhancer-binding factor 3 antibody; M phase phosphoprotein 4 antibody; M-phase phosphoprotein 4 antibody; MPHOSPH4 antibody; MPP4 antibody; NF AT 90 antibody; NF-AT-90 antibody; NF110 antibody; NF90 antibody; NFAR antibody; Nuclear factor associated with dsRNA antibody; Nuclear factor of activated T cells 90 kDa antibody; Nuclear factor of activated T-cells 90 kDa antibody; TCP80 antibody; Translational control protein 80 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NF90,ILF3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs.
  • 基因功能參考文獻:
    1. DNA- and RNA-binding protein NF90/ILF3/NF110 associates with chromatin to hierarchically regulate transcription factors that promote proliferation and suppress differentiation. PMID: 29590119
    2. Reprot a coordinated regulation of circRNA biogenesis and function by NF90/NF110 in viral infection. PMID: 28625552
    3. The NF90 regulates PARP1 mRNA stability in hepatocellular carcinoma cells, and NF90 is a potential target to inhibit PARP1 activity. PMID: 28487110
    4. Variants in ILF3 gene is associated with thrombosis. PMID: 26908601
    5. these data establish miR-590-5p as an anti-onco-miR that inhibits colorectal cancer angiogenesis and metastasis through a new mechanism involving NF90/VEGFA signaling axis. PMID: 27735951
    6. NF90 exerts its antiviral activity by antagonizing the inhibitory role of NS1 on PKR phosphorylation PMID: 27423063
    7. These data suggest that, like ADAR2, underlying sequences in dsRNA may influence how NF90 recognizes its target RNAs PMID: 26712564
    8. The NF90 C-terminus is involved in conformational changes in the protein after RNA binding. PMID: 26795062
    9. Taken together, our discovery of the function of TCP80 and RHA in regulating p53 IRES and p53 induction following DNA damage provides a better understanding of the mechanisms that regulate IRES-mediated p53 translation in response to genotoxic stress. PMID: 26273641
    10. data suggest that lncRNA SALNR modulates cellular senescence at least partly through changing NF90 activity PMID: 26491010
    11. Data indicate the role of cyclin-dependent kinase inhibitor 1A (p21) and interleukin enhancer binding factor 3 (ILF3) pathway in mediating the anti-leukemic activity of sodium dichloroacetate (DCA) in oncoprotein p53null leukemic cells. PMID: 25544776
    12. Suppression of NF90 caused a decrease in the half-life of cyclin E1 mRNA PMID: 25399696
    13. the role of the human NF90 protein isoforms in DNA and RNA virus replication PMID: 25447144
    14. NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells. PMID: 24623135
    15. The function of NF90 in posttranscriptional gene regulation and microRNA biogenesis. [Review] PMID: 23965975
    16. Data indicate that knockdown of interleukin enhancer-binding factor 3 (ILF3) leads to the increased levels of mature urokinase-type plasminogen activator (uPA) mRNA-targeting miRNAs miR-193a, miR-193b and miR-181a. PMID: 22986534
    17. contributes to maintaining low levels of senescence-associated secretory phenotype factors in non-senescent cells PMID: 23117626
    18. The unique C-terminal region of ILF3/NF110 is important for promoting survivin expression and for high affinity binding to YM155. PMID: 22442257
    19. high expression of ERCC1, XPB and ILF3 was observed in human epithelial ovarian cancer PMID: 21971700
    20. These data suggest that DRBP76, via its association with VP35, exerts an anti-Ebola virus function. PMID: 21987769
    21. The protein polymorphism of Ilf3/NF90 and the various subcellular localizations of their isoforms may partially explain the various functions previously reported for these proteins. PMID: 21811582
    22. associations of rs2569512 of ILF3 to myocardial infarction among individuals stratified by the absence or presence of hypertension, diabetes mellitus and chronic kidney disease PMID: 21347509
    23. Production of HIV particles is regulated by altering sub-cellular localization and dynamics of Rev induced by double-strand RNA binding protein. PMID: 21364984
    24. NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus. PMID: 21386893
    25. The relationship between rs6929846 of BTN2A1 or rs2569512 of ILF3 and myocardial infarction is influenced by the serum concentrations of high density lipoprotein cholesterol and low density lipoprotein cholesterol, respectively. PMID: 21468600
    26. Data suggest that physiologic DRBP76 expression, isoform distribution and subcellular localization are profoundly altered upon malignant transformation. PMID: 20668518
    27. Nuclear export of this protein is required for interleukin-2 mRNA stabilization. PMID: 12504009
    28. Results describe the expression of four isoforms of nuclear factor 90, including NF110, by cDNA cloning and mass spectrometric analysis of proteins isolated from human cells PMID: 12946349
    29. nuclear export of ILF3 is mediated by exportin-5 and minihelix-containing RNA PMID: 14570900
    30. the multiple cellular functions, i.e., translation control, interleukin-2 enhancer binding, or cell division, of ILF3 are fulfilled by alternatively spliced isoforms. PMID: 14654356
    31. NF90 and NF110 engage RNA differentially and translocate from the nucleus to the cytoplasm in mitosis PMID: 15811368
    32. ADAR1 has the potential both to change information content through editing of mRNA and to regulate gene expression through interacting with NF90 PMID: 16055709
    33. The human Nuclear Factor 90 c-terminal variant protein encoded by ILF3 interacts with Rev to inhibit Rev-mediated RNA transport. PMID: 17125513
    34. Our results show that perturbation Tat/TAR RNA interaction by the dsRNA binding nuclear factor 90 protein is sufficient to inhibit transcriptional activation of HIV-1. PMID: 17565699
    35. DRBP76/NF90 isoform facilitates VEGF expression by promoting VEGF mRNA loading onto polysomes PMID: 18039850
    36. NFARs exert influence on mRNA trafficking and the modulation of translation rates and may constitute an innate immune translational surveillance mechanism important in host defense countermeasures against virus infection PMID: 18337511
    37. MKP-1 upregulation by oxidative stress is potently influenced by increased mRNA stability and translation, mediated at least in part by the RNA-binding proteins HuR and NF90. PMID: 18490444
    38. ILF-3, which has been known to regulate IL-2 expression in T cells, up-regulates synoviolin expression with GABPalpha in rheumatoid synovial cells PMID: 19116932
    39. NF90 inhibits influenza virus replication during the early phase of infection through direct interaction with viral NP. PMID: 19494010

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Cytoplasm. Nucleus.
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 6038

    OMIM: 603182

    KEGG: hsa:3609

    STRING: 9606.ENSP00000404121

    UniGene: Hs.465885



主站蜘蛛池模板: 极品国产主播粉嫩在线| 久久天天躁狠狠躁夜夜躁2014| 国产免费观看黄av片| 国产情侣激情在线视频| 亚洲国产欧美中文丝袜日韩| 日本不卡一区| 亚洲欧美日韩国产手机在线| 国产成人精品久久久久精品日日| 无码伊人66久久大杳蕉网站谷歌| 一二三四在线视频观看社区| 国产内射合集颜射| 久久婷婷六月综合色液啪| 欧美两根一起进3p在线观看| 久久亚洲精品成人av| 一本一道av无码中文字幕| 久久精品99无色码中文字幕| 久久精品无码av| 日韩成人无码中文字幕| 两个美女裸体舌吻互扒内裤| 在线观看国产精品av | 精品熟女日韩中文十区| 东京道一本热中文字幕| 国产亚洲精选美女久久久久| 国产香蕉尹人在线观看视频| 成品人视频ww入口| 成人无码a片一区二区三区免| 99国产揄拍国产精品人妻| 国产亚州精品女人久久久久久| 国产亚洲精品久久久久久久软件| 亚洲春色av无码专区在线播放| 少妇裸交aa大片| 亚洲人成无码网站久久99热国产 | 中文精品久久久久国产网址| 乱中年女人伦av| 少妇爆乳无码专区网站| 无码午夜人妻一区二区三区不卡视频| 日韩综合无码一区二区| 日本中文一二区有码在线| 精品国产成人网站一区在线| 亚洲精品无码永久在线观看性色| 亚洲中文字幕永久在线不卡|