在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL4I1 Antibody, Biotin conjugated

IL4I1 Antibody, Biotin conjugated

  • 中文名稱：
    IL4I1兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA850426LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) IL4I1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    IL4I1
  • 別名：
    IL4I1 antibody; FIG1 antibody; UNQ636/PRO1265 antibody; L-amino-acid oxidase antibody; LAAO antibody; LAO antibody; EC 1.4.3.2 antibody; Interleukin-4-induced protein 1 antibody; IL4-induced protein 1 antibody; Protein Fig-1 antibody; hFIG1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human L-amino-acid oxidase protein (139-339AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Secreted L-amino-acid oxidase that acts as a key immunoregulator. Has preference for L-aromatic amino acids: converts phenylalanine (Phe), tyrosine (Tyr) and tryptophan (Trp) to phenylpyruvic acid (PP), hydroxyphenylpyruvic acid (HPP), and indole-3-pyruvic acid (I3P), respectively. Also has weak L-arginine oxidase activity. Acts as a negative regulator of anti-tumor immunity by mediating Trp degradation via an indole pyruvate pathway that activates the transcription factor AHR. IL4I1-mediated Trp catabolism generates I3P, giving rise to indole metabolites (indole-3-acetic acid (IAA) and indole-3-aldehyde (I3A)) and kynurenic acid, which act as ligands for AHR, a ligand-activated transcription factor that plays important roles in immunity and cancer. AHR activation by indoles following IL4I1-mediated Trp degradation enhances tumor progression by promoting cancer cell motility and suppressing adaptive immunity. Also has an immunoregulatory function in some immune cells, probably by mediating Trp degradation and promoting downstream AHR activation: inhibits T-cell activation and proliferation, promotes the differentiation of naive CD4(+) T-cells into FOXP3(+) regulatory T-cells (Treg) and regulates the development and function of B-cells. Also regulates M2 macrophage polarization by inhibiting T-cell activation. Also has antibacterial properties by inhibiting growth of Gram negative and Gram positive bacteria through the production of NH4(+) and H2O2.
  • 基因功能參考文獻(xiàn)：
    1. the presence of IL4I1 during T-cell activation decreases early signaling events downstream of t-cell receptor stimulation, resulting in global T-cell inhibition which is more pronounced when there is CD28 costimulation. PMID: 28891065
    2. Data showed proteome changes in alveolar epithelial cells type II exposed to an infection with A. fumigatus with IL4I1 showing the most prominent increase in abundance both, in terms of relative abundance as well as activity. Also, in the infected lungs, there was levels of IL4I1 metabolic products. PMID: 28951444
    3. reviewed SNPs of the IL4I1 isoform 1, which is expressed in lymphoid tissue; the N92D SNP leads to a hyperactive enzyme, while the R102G mutation is hypomorphic; show that IL4I1 activity is not only directed against phenylalanine, as initially described, but also at a lower level against arginine PMID: 26673964
    4. The immunosuppressive enzyme IL4I1 expressed differentially in human induced Aiolos+, but not natural Helios+, FOXP3+ Treg cells. PMID: 25446972
    5. IL4I1 upregulation in human Th17 cells limits their TCR-mediated expansion not only by blocking the molecular pathway involved in the activation of the IL-2 promoter, but also by maintaining high levels of Tob1, which impairs entry into the cell cycle. PMID: 24307243
    6. IL4I1 plays a distinct role compared to other antibacterial enzymes produced by mononuclear phagocytes. PMID: 23355881
    7. participates in the downregulation of Th1 inflammation PMID: 20683900
    8. genomic structure, cDNA sequence, chromosome location and RNA expression in immune tissues PMID: 12031486
    9. is activated in primary mediastinal large B-cell lymphoma, which might be due to a constitutive activation of a cytokine signaling pathway PMID: 12446450
    10. hIL4I1 inhibited the proliferation of CD3-stimulated T lymphocytes with a similar effect on CD4(+) and CD8(+) T cells. In contrast, memory T cells were more strongly affected by hIL4I1 and its catabolite H(2)O(2) than naive T cells PMID: 17356132
    11. strong IL4I1 expression is associated with B-cell lymphomas. PMID: 19436310

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Secreted. Lysosome. Cytoplasmic vesicle, secretory vesicle, acrosome.
  • 蛋白家族：
    Flavin monoamine oxidase family, FIG1 subfamily
  • 組織特異性：
    Primarily found in immune tissues, with the highest expression in lymph nodes and spleen. Present in germinal center macrophages and inflammatory myeloid cells and antigen-presenting cells (at protein level). Also present in spermatozoa (at protein level)
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19094

    OMIM: 609742

    KEGG: hsa:259307

    STRING: 9606.ENSP00000342557

    UniGene: Hs.574492



主站蜘蛛池模板： 久久久精品波多野结衣| 人妻少妇av无码一区二区| 欧美熟妇的性裸交| 四虎影视无码永久免费| 亚洲精品色播一区二区| 精品国产av一区二区果冻传媒| 亚洲性av网站| 欧美肥老太交性506070| 日日摸日日碰人妻无码| h肉动漫无码无修6080动漫网| 亚洲日韩av一区二区三区中文| 无码国产欧美一区二区三区不卡| 52熟女露脸国语对白视频| 国产福利一区二区麻豆| 国产内射爽爽大片| 女人下边被添全过视频| 色老久久精品偷偷鲁| 成人午夜电影福利免费| 午夜人成免费视频| 日本一区二区三区免费播放| 精品无人区无码乱码毛片国产| 免费人成视频x8x8入口| 一本色道av久久精品+网站| 亚洲色欲色欲天天天www| 亚洲色素色无码专区| 久久国产一区二区三区| 久久精品无码一区二区三区| 熟女熟妇伦av网站| 亚洲精品无码精品mv在线观看| 国产精品久久久久蜜芽| 天天摸日日摸狠狠添| 亚洲国产天堂久久综合| 麻豆国产人妻欲求不满| 久久精品娱乐亚洲领先| 色噜噜狠狠狠综合曰曰曰| 久久午夜夜伦鲁鲁片无码免费| 永久免费的av在线电影网| 在线不卡av片免费观看| 国产suv精品一区二区| 国产a√精品区二区三区四区| 中文天堂在线资源www|