在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL32 Antibody, Biotin conjugated

  • 中文名稱:
    IL32兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA08309D0Rb
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IL32 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    IL32
  • 別名:
    IL 32alpha antibody; IL 32beta antibody; IL 32delta antibody; IL 32gamma antibody; IL-32 antibody; IL32 antibody; IL32_HUMAN antibody; Interleukin 32 antibody; Interleukin 32 small antibody; Interleukin 32 theta antibody; Interleukin-32 antibody; interleukin-32 eta antibody; Natural killer cell transcript 4 antibody; Natural killer cells protein 4 antibody; NK 4 antibody; NK4 antibody; OTTHUMP00000236040 antibody; OTTHUMP00000236041 antibody; OTTHUMP00000236042 antibody; OTTHUMP00000236043 antibody; OTTHUMP00000236044 antibody; OTTHUMP00000236045 antibody; OTTHUMP00000236046 antibody; OTTHUMP00000236047 antibody; OTTHUMP00000236048 antibody; OTTHUMP00000236049 antibody; OTTHUMP00000236050 antibody; OTTHUMP00000236051 antibody; OTTHUMP00000236052 antibody; OTTHUMP00000236053 antibody; OTTHUMP00000236054 antibody; OTTHUMP00000241545 antibody; OTTHUMP00000241602 antibody; OTTHUMP00000241603 antibody; OTTHUMP00000241604 antibody; OTTHUMP00000241605 antibody; OTTHUMP00000241606 antibody; OTTHUMP00000241607 antibody; OTTHUMP00000241608 antibody; OTTHUMP00000241609 antibody; OTTHUMP00000241610 antibody; OTTHUMP00000241611 antibody; OTTHUMP00000241612 antibody; TAIF antibody; TAIFa antibody; TAIFb antibody; TAIFc antibody; TAIFd antibody; Tumor necrosis factor alpha-inducing factor antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interleukin-32 protein (31-234AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cytokine that may play a role in innate and adaptive immune responses. It induces various cytokines such as TNFA/TNF-alpha and IL8. It activates typical cytokine signal pathways of NF-kappa-B and p38 MAPK.
  • 基因功能參考文獻:
    1. IL-32gamma functions as intracellular effector in hepatocytes for suppressing hepatitis b virus replication. PMID: 30115930
    2. Results indicate that interleukin-32 gamma (IL-32gamma) plays a protective role for bone loss, providing clinical evidence of a negative correlation between IL-32gamma and DKK1 (Dickkopf-1) as bone metabolic markers. PMID: 28079119
    3. Our study shows a functional effect of a promoter single-nucleotide polymorphism (SNP) in IL32 on lipid profiles in RA patients and individuals, suggesting a possible protective role of this SNP against CVD. PMID: 28134327
    4. IL-32 may be an important pro-inflammatory molecule involved in calcific aortic valve disease. PMID: 29748157
    5. High IL32 expression is associated with hepatocellular carcinoma. PMID: 29286122
    6. Strong expression of IL-32 was detected in cardiomyocytes from heart failure patients. PMID: 28747035
    7. The increase in serum levels of IL-32 in accordance with additive effect of the presence of C allele in Multiple sclerosis patients might introduce IL-32 as a key player in MS pathogenesis or immunedysregulation PMID: 28716229
    8. high expression of both IL17A and IL32 leads to enhancement of T cell responses in breast tumors PMID: 28470472
    9. In transgenic mice, the presence of IL-32gamma contributes to the lesion healing caused by Leishmania braziliensis but not by Leishmania amazonensis. PMID: 28709468
    10. High IL32 expression is associated with lung metastasis in melanoma. PMID: 27589563
    11. In Kaposi sarcoma (KS) splicing ratio of the IL-32 isoforms showed IL-32gamma as the highest expressed isoform, followed by IL-32beta, in HIV-related KS cases compared with controls. Our data suggest a possible survival mechanism by the splicing of IL-32gamma to IL-32beta and also IL-6, IL-8, and CXCR1 signaling pathways to reverse the proapoptotic effect of the IL-32gamma isoform, leading to tumor cell survival and th... PMID: 29037857
    12. Three single nucleotide polymorphisms (SNPs) (rs28372698, rs12934561, rs4786370) of the IL32 gene have been proposed as modifiers for different diseases. The present study found no significant differences in the genotypic frequencies between the patients and healthy controls and no relation to survival for any of the SNPs. PMID: 29277790
    13. This study showed that the induction level of IL-32 was increased in chronic rhinosinusitis with nasal polyps compared to normal nasal mucosa and that LPS-induced IL-32 expression in nasal polyp-derived fibroblasts was regulated via the TLR4/JNK/AKT/CREB signaling pathway. PMID: 27173130
    14. findings show that IL-32alpha acts on NK cells to inhibit IL-15-mediated STAT5 phosphorylation and to suppress their IL-15-induced effector molecule expression and cytolytic capacity. IL-32alpha also acted on DCs by downregulating IL-15-induced IL-18 production, an important cytokine in NK cell activity. PMID: 28701509
    15. Thus, endogenous IL-32 is a crucial cytokine involved in the host defense against Leishmania parasites. PMID: 28241012
    16. Study indicated the overexpression of IL-32 in induced sputum of smokers and chronic obstructive pulmonary disease (COPD) patients, which was correlated with smoking exposure index and the degree of airway obstruction. It demonstrated that IL-32 might play critical role in smokers with COPD. PMID: 24761997
    17. this study shows that IL-32 might be involved in the pathogenesis of hepatic fibrosis by inducing TIMP-1 expression PMID: 27302771
    18. serum levels of IL-32 and TNF-alpha may be diagnostic markers, and serum IL-29 levels may be associated with good prognosis in patients with gastric cancer PMID: 26219901
    19. the importance of IL-32 polymorphism and mRNA expression in susceptibility and influence of survival status in lung cancer PMID: 27775437
    20. Data identify interleukin-32 (IL-32) as a potential therapeutic target. PMID: 26978598
    21. Low IL-32 expression is associated with colon cancer. PMID: 26824417
    22. Results show low plasma IL-32 levels in patients with systemic lupus erythematosus (SLE) and the rs28372698 SNP was associated with the susceptibility to SLE suggesting a possible role as a candidate marker to monitor SLE disease stability and screening in future. PMID: 27069296
    23. High IL32 expression is associated with acute myeloid leukemia. PMID: 26516703
    24. highlight some of the potential mechanisms by which the immunomodulatory effect of IL-32 occurs against mycobacterial infections but also areas where mechanistic clarifications are needed PMID: 26144292
    25. Additional IL-32gamma stimulation in precursor cells enhanced osteoblast differentiation potentially PMID: 26634249
    26. This study demonstrates that IL-32gamma and IL-32beta can induce caspase-8-dependent cell death whereas this was not observed for IL-32alpha PMID: 26678222
    27. High IL32 expression is associated with Sezary syndrome. PMID: 26551670
    28. soluble IL-6R expression upregulated the levels of its own ligand, IL-6 and those of the pro-inflammatory cytokine IL-32. PMID: 25176527
    29. Our results suggest that NKP30-B7-H6 interaction can aggravate hepatocyte damage, probably through up-regulation of IL-32 expression in hepatitis B virus-related acute-on-chronic liver failure PMID: 26241657
    30. These results suggest that IL-32beta could activate NF-kappaB and STAT3, and thus affect neuroinflammation as well as amyloidogenesis, leading to worsening memory impairment. PMID: 25159479
    31. IL-32 is involved in the pathogenesis of airway inflammation. PMID: 26151454
    32. High IL-32 expression may stimulate the organic metastasis and the lymph node metastasis of colorectal cancer. PMID: 25889282
    33. data further confirms that reduced IL32 methylation is associated with JIA, and that SNPs play an interactive role PMID: 26057774
    34. IL-32alpha can prevent cerebral ischemia damage via STAT3 activation and inhibition of NF-kappaB activation. PMID: 24854197
    35. In IL-32alpha-Tg mice, azoxymethane-induced colon cancer incidence was decreased, but expression of TNFR1 and TNFR1-mediated apoptosis was increased. IL-32alpha increased ROS production, prolonging JNK activation. In colon cancer patients, IL-32alpha was increased. PMID: 25909160
    36. IL-32 stimulation promotes the invasion and motility of osteosarcoma cells, possibly via the activation of AKT and the upregulation of MMP-13 expression. PMID: 25846944
    37. The anti-Mycobacterium tuberculosis effects of IL-32gamma are mediated through classical caspase-3-dependent apoptosis as well as caspase-3-independent apoptosis. PMID: 25887904
    38. IL-32 gamma delays, in a dose-dependent manner, the spontaneous apoptosis of human blood neutrophils by activating mainly p38 MAPK through rapid p38 phosphorylation. PMID: 25275312
    39. we demonstrate that the newly discovered isoform, IL-32theta;, suppresses monocyte differentiation by regulating the expression of the PU.1 transcription factor. PMID: 25726525
    40. This study demonstrates that IL-32 gene polymorphisms are significantly associated with increased endometrial cancer susceptibility in Chinese Han women PMID: 25663496
    41. These results suggest that IL-32gamma enhances an innate immune response against local infection but inhibits the spread of immune responses, leading to systemic immune disorder. PMID: 24743568
    42. Transgenic mice that express human interleukin-32 are protected from high-fat diet-induced hepatic steatosis. PMID: 25645248
    43. overexpression of IL-32gamma contributes to initial islet beta-cells injury and inflammation in pancreas and aggravates streptozotocin-induced type 1 diabetes. PMID: 25022955
    44. IL32 may play a unique role in mycosis fungoides progression as an autocrine cytokine PMID: 24938282
    45. Our results clearly suggest that IL-32 is an important mediator for gastric cancer metastasis and independent prognostic predictor of gastric cancer. PMID: 24602839
    46. The Epstein-Barr virus LMP1-induced IL-32 traps protein kinase Cdelta in the cytoplasm and prevents it from binding to the Zta promoter, which is the key event for virus activation. PMID: 25810549
    47. IL-32theta;, through its interaction with PKCdelta, downregulates CCL5 expression by mediating the phosphorylation of STAT3 on Ser727 to render it transcriptionally inactive. PMID: 25280942
    48. IL-32gamma enhances host immunity to Mycobacterium tuberculosis. PMID: 25820174
    49. IL-32alpha inhibits BCL6 SUMOylation by activating PKCepsilon, resulting in the modulation of BCL6 target genes and cellular functions of BCL6. PMID: 25245533
    50. IL-32gamma prevents ethanol-induced hepatic injury via the inhibition of oxidative damage and inflammatory responses. PMID: 25583360

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 組織特異性:
    Selectively expressed in lymphocytes. Expression is more prominent in immune cells than in non-immune cells.
  • 數據庫鏈接:

    HGNC: 16830

    OMIM: 606001

    KEGG: hsa:9235

    UniGene: Hs.943



主站蜘蛛池模板: 精品久久久无码中文字幕| 噜噜色综合天天综合网mp3 | 强行从后面挺进人妻| 日韩激情无码不卡码| 国产欧美另类久久精品蜜芽| 亚洲粉嫩高潮的18p| 国产又黄又湿无遮挡免费视频| 裸身美女无遮挡永久免费视频| 丁香色欲久久久久久综合网| 在线岛国片免费无码av| 中国丰满熟妇av| 欧美黑人乱大交| 成人影片麻豆国产影片免费观看 | 国内揄拍国内精品对白| 综合激情五月综合激情五月激情1| 亚洲成a人v电影在线观看| 精品国产va久久久久久久冰| 欧美日韩精品一区二区三区不卡| 特级a做爰全过程片| 丰满又黄又爽少妇毛片| 国产裸拍裸体视频在线观看| 巨胸美乳无码人妻视频| 国产av区男人的天堂| 亚洲一区二区av在线观看| 久在线观看福利视频| 久久久精品2020免费观看| 日日碰狠狠添天天爽超碰97| 最新国产在线拍揄自揄视频| 特大巨黑吊xxxx高潮| 日韩在线永久免费播放| 日韩人妻无码精品二专区| 国产精品免费大片| 天天躁日日躁狠狠躁超碰97| 久久青青草原精品国产app| 好男人社区影院www| 亚洲精品久久久久久一区二区| 日产乱码一区二区三区在线| 日本 精品 高清不卡| 一本色道无码不卡在线观看| 日本又色又爽又黄的视频免| 中文字幕一区二区三区久久网站|