在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL26 Antibody

  • 中文名稱:
    IL26兔多克隆抗體
  • 貨號:
    CSB-PA179989
  • 規格:
    ¥1090
  • 圖片:
    • Western blot analysis of RAT-MUSLE RAT-SPLEEN 293T SH-SY5Y using IL26 antibody. Antibody was diluted at 1:2000. Secondary antibody was diluted at 1:20000
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    AK155 antibody; IL 26 antibody; IL-26 antibody; IL26 antibody; IL26_HUMAN antibody; Interleukin 26 antibody; Interleukin-26 antibody; Protein AK155 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human IL-26.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin.
  • 基因功能參考文獻:
    1. this paper shows that IL-26 is overexpressed in Behcet's disease and enhances Th17 related -cytokines PMID: 28811236
    2. The varIL26 genotype is associated with reduced PMN capacity to kill bacteria. A varIL26 genotype is associated with decreased levels of anti-TNF-alpha in CD patients. IL26 may help explain the role of bactDNA as a risk factor of flare in CD patients. PMID: 28879509
    3. IL-26 activates STAT1/3 and leads to the induction of IL-6 and IL-8 expression in non-transformed cells derived from human colon. PMID: 28852311
    4. IL-26 levels are higher in synovial fluid compared to plasma in spondyloarthritis. IL-26 was identified in axial facet joints of spondyloarthritis patients. Myofibroblasts from the spondyloarthritis synovium produce large amounts of IL-26. IL-26 induces bone mineralization in human osteoblasts. PMID: 28365787
    5. this study shows that IL-26 is a unique cationic protein more similar to a soluble pattern recognition receptor than to conventional cytokines PMID: 28356384
    6. this study shows that single nucleotide polymorphism near IL-26 gene is associated with familial vitiligo and existence of halo nevi in Estonian patients PMID: 26429320
    7. Our study indicates that IL-26 is a potential biomarker of disease severity in pediatric asthma without signs of Th2-mediated inflammation. PMID: 27029915
    8. IL-26 is emerging as a potentially important player in host defense and may also be a pathogenic factor in the chronic inflammatory disorders of humans. [Review] PMID: 26202572
    9. The negative influence of IL-26 on the anti-mycobacterial activity and its constitutive presence in both serum and monocyte supernatants prompt a proposal that IL26 as a candidate gene for tuberculosis susceptibility. PMID: 25157980
    10. IL-26 differentially modulates the infection by different enveloped viruses. PMID: 23875025
    11. Elevated levels of IL-26 in human gastric cancer promote proliferation and survival by modulating STAT1/STAT3 signaling. PMID: 23704922
    12. IL-26 appears as a novel proinflammatory cytokine, located upstream of the proinflammatory cascade, that may constitute a promising target to treat rheumatoid arthritis and chronic inflammatory disorders. PMID: 23055831
    13. Identify a second enhancer element positioned between IL26 and IFNG required for both IL26 and IFNG expression. One function of this enhancer is to facilitate recruitment of RNA polymerase II to promoters of both genes. PMID: 22622197
    14. common polymorphisms in the IFNgamma/IL-26 gene region may contribute to sex bias in susceptibility to rheumatoid arthritis, by distorting the propensity of female carriers versus male carriers to contract this disease. PMID: 14558082
    15. The active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20 receptor 1 and IL-10 receptor 2. Signaling through the IL-26 receptor results in activation of STAT1 and STAT3. PMID: 14764663
    16. sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 receptor 1 and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction PMID: 15178681

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    IL-10 family
  • 組織特異性:
    Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protei
  • 數據庫鏈接:

    HGNC: 17119

    OMIM: 605679

    KEGG: hsa:55801

    STRING: 9606.ENSP00000229134

    UniGene: Hs.272350



主站蜘蛛池模板: 97人人模人人爽人人少妇| 久久国产劲爆∧v内射| 免费国产黄网站在线观看动图| а天堂8中文最新版在线官网| 日本亲近相奷中文字幕| 国产一区二区三区在线蜜桃| 国产极品白嫩精品| 亚洲欧洲自拍拍偷精品 美利坚| 亚洲精品无码久久毛片波多野吉衣 | 人人爽人人澡人人人妻、百度| 粉嫩极品国产在线观看| 亚洲一区二区三区四区五区六| 国产精品一线二线三线| 一本色综合网久久| 怡春院久久国语视频免费| 久久婷婷狠狠综合激情| 色琪琪av中文字幕一区二区| 国产精品无码一区二区三区在| 又粗又硬又大又爽免费视频播放| 波多野结衣的av一区二区三区| 亚洲一二三四2021不卡| 中文无码伦av中文字幕在线| 黑人大战欲求不满人妻| 大黑人交xxxx18视频| 日本添下边视频全过程| 国产精品无码无卡无需播放器| 亚洲性夜夜综合久久7777| 久久狼人大香伊蕉国产| 中国白嫩丰满人妻videos| 黄页网址大全免费观看| 99久久精品国产一区二区三区| 日本中文字幕人妻不卡dvd| 亚洲乱码中文字幕小综合| 亚洲色精品aⅴ一区区三区| 天天爽夜夜爽夜夜爽精品视频| 久久五月丁香激情综合| 丰满又黄又爽少妇毛片| 一二区成人影院电影网| 97人妻人人做人碰人人爽| 少妇白浆呻吟爽| 国产成人综合久久免费|