在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL22RA1 Antibody

  • 中文名稱:
    IL22RA1兔多克隆抗體
  • 貨號:
    CSB-PA011636GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CRF2 9 antibody; CRF2-9 antibody; Cytokine receptor class-II member 9 antibody; cytokine receptor classII member 9 antibody; Cytokine receptor family 2 member 9 antibody; I22R1_HUMAN antibody; IL-22 receptor subunit alpha-1 antibody; IL-22R-alpha-1 antibody; IL-22RA1 antibody; IL22 Receptor Alpha antibody; IL22R antibody; IL22R1 antibody; Il22ra1 antibody; ILTIF R1 chain antibody; Interleukin 22 Receptor alpha 1 antibody; Interleukin 22 Receptor antibody; Interleukin-22 receptor subunit alpha-1 antibody; ZcytoR11 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human IL22RA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.
  • 基因功能參考文獻:
    1. increased expression of IL-22Ralpha therefore promotes keratinocyte proliferation and pro-inflammatory cytokine production during UVB-induced skin inflammation, suggesting that UVB facilitates skin inflammation by increasing the responsiveness of keratinocytes to IL-22 PMID: 28558005
    2. IL-22 and its receptor have a crucial role in the development and pathogenesis of uveitis by facilitating inflammatory cell infiltration. PMID: 27166675
    3. high expression profile of IL-22R1 in nonsmall cell lung cancer is an independent indicator of poor overall survival PMID: 26846835
    4. phosphorylation of STAT3 and AKT was highly induced by treatment with IL-22 via IL-22R1. IL-22R1 was also consistently overexpressed in recurrent NSCLC tissues PMID: 26983629
    5. These data suggest that imbalance of IL-22/IL-22R1 signaling regulates the pathogenesis of chronic rhinosinusitis with nasal polyps, including local eosinophilia, via alteration of MUC1 expression. PMID: 27502468
    6. FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment. PMID: 26171402
    7. IL-22R1 is over-expressed in primary Sjogren's syndrome and Sjogren-associated non-Hodgkin lymphomas and is regulated by IL-18. PMID: 25880879
    8. IL-22 has restricted tissue specificity as its unique receptor IL-22R1 is exclusively expressed on epithelial and tissue cells, but not immune cells. PMID: 24856143
    9. serum IL-22 levels are significantly higher in patients with pituitary macroadenomas than in healthy controls and IL-22R is variably expressed in both prolactinoma and non-functioing pituitary adenoma cells. PMID: 23512698
    10. High expression of interleukin-22 receptor is associated with pancreatic ductal adenocarcinoma. PMID: 24132627
    11. the CC genotype of rs3795299 polymorphism in the IL-22R1 gene is associated with the reduced risk of IgAN, and this genetic association was supported by the higher renal expression of IL-22R1 in healthy controls compared with patients with IgAN. PMID: 23659670
    12. Letter: calcipotriol inhibits the IL-22-induced epidermal hyperplasia by decreasing keratinocyte proliferation and down-modulating IL-22R expression. PMID: 23688404
    13. Data show that IL-17RA, IL-17RC, IL-22R1, ERK1/2 MAPK and NF-kappaB pathways are involved in Th17 cytokine-induced proliferation. PMID: 22898922
    14. IL-22R1 mRNA and protein expressions in HASMCs were significantly increased after stimulation by serum from asthmatic patients, but decreased after co-stimulation with dexamethasone. PMID: 21690049
    15. This study documents a previously unknown role of IL-22R1 in inflammation and identifies the involvement of IL-22R1/IL-22 in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma PMID: 20971950
    16. Tyr251 and Tyr301 of IL-22R1 are required for Shp2 binding and IL-22-induced Erk1/2 activation. PMID: 20671117
    17. study demonstrated IL-22R1 mRNA and protein expression on nasal epithelial cells; failure of medical and surgical therapy in chronic rhinosinusitis with nasal polyps is associated with significantly decreased expression of IL-22R1 PMID: 17906500
    18. The islets of Langerhans are the local site for IL-22R1 expression in the human pancreas. PMID: 18376313
    19. Molecular basis for the distinct affinities and specificities of IL-22 and IL-10 receptor chains that regulate cellular targeting and signal transduction to elicit effective immune responses. PMID: 18599299
    20. A 1.9A crystal structure of the IL-22/IL-22R1 complex is reported. PMID: 18675809
    21. identifies those amino acid side chains of IL-22 that are individually important for optimal binding to IL-22R PMID: 18675824
    22. Comparison of IL-22/IL-22BP and IL-22/IL-22R1 crystal structures shows that both receptors display an overlapping IL-22 binding surface, which is consistent with the inhibitory role played by IL-22 binding protein. PMID: 19285080
    23. Data show that deletion of the C-terminal part of IL-22R dramatically decreased its ability to activate STAT3. PMID: 19632985
    24. Increased IL-22R expression in epidermal keratinocytes contributes to the pathogenesis of psoriasis through enhancing the coordinated effects of IL-22 and IL-17, inducing the production of the IL-20 subfamily, chemokines, and growth factors. PMID: 19731362

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Type II cytokine receptor family
  • 組織特異性:
    Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial
  • 數據庫鏈接:

    HGNC: 13700

    OMIM: 605457

    KEGG: hsa:58985

    STRING: 9606.ENSP00000270800

    UniGene: Hs.110915



主站蜘蛛池模板: 六月丁香综合在线视频| 欧美牲交a欧美牲交aⅴ一| 天堂在线观看www| 久久亚洲一区二区三区四区五区| 国内精品伊人久久久久影院对白| 亚洲国产精品无码久久秋霞| 国产福利免费视频不卡| 精品少妇无码av无码专区| 青娱乐极品视觉盛宴国产视频| 久久精品女人的天堂av| 人妻系列无码专区喂奶| 情侣激情18内射骚话国产 | 亚洲 激情 小说 另类 欧美| 性欧美俄罗斯极品| 久久久久国色av∨免费看| 青青草视频免费观看| 亚洲亚洲人成网站网址| 青青青国产免a在线观看| 伊人成伊人成综合网222| 人人狠狠综合久久亚洲爱咲| 欧美极品少妇无套实战| 最近2019中文字幕大全第二页| 亚洲va久久久噜噜噜久久天堂| 色欲久久综合亚洲精品蜜桃 | 中文字幕一区在线观看视频| 久久午夜福利无码1000合集| 特黄特级毛片免费视频| 久久久久久成人综合网| 日本xxxxx片免费观看喷水| 精品欧美一区二区三区久久久| 又污又爽又黄的网站| 尹人香蕉久久99天天拍欧美p7| 色偷偷久久一区二区三区| 亚洲高清最新av网站| 午夜福利国产成人无码gif动图| av色国产色拍| 亚洲人成人无码www影院 | 国产尤物精品视频| 看国产黄大片在线观看| a欧美爰片久久毛片a片| 天天av天天翘天天综合网|