在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL1RAPL1 Antibody, FITC conjugated

  • 中文名稱:
    IL1RAPL1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA011624LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IL1RAPL1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    IL 1 RAPL 1 antibody; IL 1RAPL 1 antibody; IL-1-RAPL-1 antibody; IL-1RAPL-1 antibody; IL1R8 antibody; IL1RAPL 1 antibody; IL1RAPL antibody; IL1RAPL-1 antibody; IL1RAPL1 antibody; Interleukin 1 receptor 8 antibody; Interleukin 1 receptor accessory protein like 1 antibody; Interleukin-1 receptor accessory protein-like 1 antibody; IRPL1_HUMAN antibody; Mental retardation X linked 10 antibody; Mental retardation X linked 21 antibody; Mental retardation X linked 34 antibody; MRX 21 antibody; MRX 34 antibody; MRX10 antibody; MRX21 antibody; MRX34 antibody; Oligophrenin 4 antibody; Oligophrenin-4 antibody; Oligophrenin4 antibody; OPHN 4 antibody; OPHN4 antibody; Three immunoglobulin domain containing IL 1 receptor related 2 antibody; Three immunoglobulin domain-containing IL-1 receptor-related 2 antibody; TIGIRR 2 antibody; TIGIRR-2 antibody; TIGIRR2 antibody; X linked interleukin 1 receptor accessory protein like 1 antibody; X-linked interleukin-1 receptor accessory protein-like 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interleukin-1 receptor accessory protein-like 1 protein (564-679AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
  • 基因功能參考文獻:
    1. Our study revealed that the expression of IL-1R8 significantly increased on in vitro-activated CD4+ T cells and was markedly higher on CD4+ T cells from allergic rhinitis patients than on cells from healthy controls. PMID: 29730558
    2. IL-1R8 serves as a checkpoint for NK cell maturation and effector function; its genetic blockade unleashes NK-cell-mediated resistance to hepatic carcinogenesis, haematogenous liver and lung metastasis, and cytomegalovirus infection in mice PMID: 29072292
    3. Altered DNA methylation in IL1RAPL1 involves in the etiology of Bipolar disorder and Major Depressive disorder . PMID: 27440233
    4. rs12007907 variant in IL1RAPL gene was negatively associated with asthma and IL-13 production in Latin American children. PMID: 28120837
    5. Our study expands the molecular repertoire of IL1RAPL1 mutations in intellectual disability and points out the need of more accurate clinical descriptions to better define the related phenotype PMID: 27470653
    6. It was indicated that a defect in IL1RAPL1 that controls excitatory synapsis formation results in the excitation-inhibition balance affecting various cerebral functions. PMID: 25864829
    7. Novel IL1RAPL1 mutations associated with intellectual disability impair synaptogenesis. PMID: 25305082
    8. The interaction of the IL1RAPL1 family of proteins with PTPdelta and RhoGAP2 reveals a pathophysiological mechanism of cognitive impairment associated with a novel type of trans-synaptic signaling. PMID: 21926414
    9. The IL1RAPL1 gene is of interest as a candidate gene for autism spectrum disorder as mutations or deletions in the gene have previously been reported in individuals from families with ASD. PMID: 21491612
    10. Intragenic deletions in IL1RAPL1are relevant to the pathogenesis of X-linked mental retardation. PMID: 21271657
    11. crystal structure at 2.3-A resolution of the TIR domain of IL-1RAPL PMID: 15123616
    12. Nearly all patients with deletions involving DAX1, but not DMD, had mental retardation if IL1RAPL1 was deleted. If ILIRAPLI & DMD were intact, the patients with DAX1 deletions only rarely had normal development. PMID: 15300857
    13. Report confirms the role of the IL1RAPL1 gene in causing nonspecific mental retardation in males. PMID: 16470793
    14. DMD gene and its immediately distal neighbor, the 1.8 Mb IL1RAPL1 gene are abundantly expressed in normal brain but were dramatically underexpressed in every brain tumor cell line and xenograft. PMID: 18253029
    15. Combined data suggested that IL1RAPL1 affected human cognitive ability to some extent, especially the memory and concentration capability. PMID: 18467032
    16. The function of truncated IL1RAPL1 protein in an autistic female with Asperger syndrome is severely altered in hippocampal neurons, demonstrated by its effect on neurite outgrowth activity. PMID: 18801879
    17. IL1RAPL1 plays an important role in the etiology of X-linked mental retardation. PMID: 19012350

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, X-linked 21 (MRX21)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasm. Cell projection, axon. Cell projection, dendrite.
  • 蛋白家族:
    Interleukin-1 receptor family
  • 組織特異性:
    Detected at low levels in heart, skeletal muscle, ovary, skin, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Detected at very low levels in tonsil, prostate, testis, small intestine, placenta, colon and fetal live
  • 數據庫鏈接:

    HGNC: 5996

    OMIM: 300143

    KEGG: hsa:11141

    STRING: 9606.ENSP00000305200

    UniGene: Hs.658912



主站蜘蛛池模板: 未满十八勿入午夜免费网站| 高清国产亚洲精品自在久久| 亚洲综合无码中文字幕第2页| 久久国产精品人妻丝袜| 亚洲一卡二卡三卡四卡无卡麻豆| 中文字幕亚洲无线码在线一区 | 一色屋精品视频在线观看免费| 欧美人与动牲交zooz| 国产精品久久久久无码av| 四虎影视久久久免费观看| 国产日产欧产精品精品免费| 日本一区不卡高清更新二区| 久久久久国产a免费观看rela| 四虎影视久久久免费观看| 日日橹狠狠爱欧美视频| 亚洲第一a在线观看网站| 性色做爰片在线观看ww | 日韩 欧美 动漫 国产 制服| 亚洲精品一区国产欧美| 变态另类牲交乱| 少妇人妻大乳在线视频| 18禁裸男晨勃露j毛免费观看| 成人高潮视频在线观看| 沈阳熟女露脸对白视频| 中文字幕一精品亚洲无线一区| 亚洲国产精品成人天堂| 亚洲国产精品无码久久久动漫| 伊人久久大香线蕉无码不卡| 成年无码av片| 99久久无码一区人妻a片蜜| 超清精品丝袜国产自在线拍| 免费人成在线观看视频高潮| 亚洲成a人片在线观看高清| 97精品国自产在线偷拍| 小13箩利洗澡无码视频网站| 少妇人妻互换不带套| 国产精品女上位好爽在线 | 国产女人高潮抽搐叫床视频| 国产日产欧产精品品不卡| 色翁荡熄又大又硬又粗又视频图片| 国产亚洲中文日韩欧美综合网|