在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL1RAP Antibody

IL1RAP Antibody

  • 中文名稱：
    IL1RAP兔多克隆抗體
  • 貨號：
    CSB-PA878844ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA878844ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA878844ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) IL1RAP Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C3orf13 antibody; FLJ37788 antibody; IL 1 receptor accessory protein antibody; IL 1R 3 antibody; IL 1R3 antibody; IL 1RAcP antibody; IL 1RAP antibody; IL-1 receptor accessory protein antibody; IL-1R-3 antibody; IL-1R3 antibody; IL-1RAcP antibody; IL-1RAP antibody; IL1 receptor accessory protein antibody; IL1AP_HUMAN antibody; IL1R3 antibody; IL1RAcP antibody; Il1rap antibody; Interleukin 1 Accessory Protein antibody; interleukin 1 receptor 3 antibody; Interleukin 1 receptor accessory protein antibody; interleukin 1 receptor accessory protein beta antibody; Interleukin-1 receptor 3 antibody; Interleukin-1 receptor accessory protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Interleukin-1 receptor accessory protein (21-356AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable).; Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling.; Unable to mediate canonical IL-1 signaling. Required for Src phosphorylation by IL1B. May be involved in IL1B-potentiated NMDA-induced calcium influx in neurons.
  • 基因功能參考文獻：
    1. Expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas PMID: 29238884
    2. These results provide novel insights into the role of IL1RAP in CML and a strong rationale for the development of an IL1RAP antibody therapy to target residual CML stem cells. PMID: 27621309
    3. single nucleotide polymorphism A471T in the Toll-interleukin 1 receptor domain (TIR) of the IL-1Rrp2 that is present in approximately 2% of the human population, down-regulated IL-36R signaling by a decrease of interaction with IL-1RAcP. PMID: 27307043
    4. The findings of this study support IL1RAP as a novel potential Alzheimer's disease target and highlight the use of amyloid PET as a valuable Alzheimer's disease endophenotype, particularly in a longitudinal framework. PMID: 26268530
    5. The SNP rs4624606 in IL-1RAcP was nominally associated with CAD risk. PMID: 25517029
    6. Data suggest serum levels of soluble IL1RAP (from alternative splicing) are down-regulated in endometriosis throughout menstrual cycle; IL1RAP levels (which peak in proliferative phase in fertile women) exhibit minor variations in endometriosis. PMID: 24935223
    7. Plasma sIL1RAP levels are reduced in obesity and can potentially act as biomarkers of obesity. PMID: 24915116
    8. Combined crystallography and small-angle X-ray-scattering studies reveal that ST2 possesses hinge flexibility between the D3 domain and D1D2 module, whereas IL-1RAcP exhibits a rigid conformation in the unbound state in solution. PMID: 23980170
    9. Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells. PMID: 22723552
    10. Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. PMID: 22778412
    11. decreased protein levels in the peritoneal fluid of women with endometriosis PMID: 21958553
    12. Studies indicate that new targets have recently been investigated as potential modulators in myeloid leukemia pathogenesis, including miR-328, BMI1, FOXOs and IL1RAP. PMID: 21373837
    13. This study showed a significant downregulation of soluble interleukin-1 receptor accessory protein expression in the endometrium of women with endometriosis. PMID: 21272866
    14. identifies IL1RAP as a unique cell surface biomarker distinguishing Ph(+) from Ph(-) candidate chronic myeloid leukemia (CML) stem cells and opens up a previously unexplored avenue for therapy of CML PMID: 20805474
    15. Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling PMID: 11880380
    16. soluble form of IL-1R AcP contributes to the antagonism of IL-1 action by the type II decoy receptor PMID: 12530978
    17. The dramatic changes in levels of IL-1RAcP mRNAs suggest important functions in regulating sensitivity to IL-1 during stress and may play a role in oncogenic processes that are engaged during chronic inflammation. PMID: 12781872
    18. IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP in Jurkat cells PMID: 14734551
    19. Specific destabilization of membrane-bound IL-1 receptor accessory protein mRNA in HepG2 hepatoma cells is mediated by its 2.8-kilobase 3'-untranslated region. PMID: 15528363
    20. Analysis of a three-dimensional docking model of the TIR-TIR interaction between MyD88 and IL1RAcP PMID: 15849357
    21. IL-1ra is associated with preserved beta-cell capacity in type 1 diabetes. PMID: 18299313
    22. an isoform of the IL-1 receptor accessory protein (termed AcPb) was identified that is expressed exclusively in the CNS. PMID: 19481478

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia
  • 數據庫鏈接：

    HGNC: 5995

    OMIM: 602626

    KEGG: hsa:3556

    UniGene: Hs.478673



主站蜘蛛池模板： 偷柏自拍亚洲综合在线| 爆乳熟妇一区二区三区 | 人妻无码一区二区三区av| 久久天天躁夜夜躁狠狠85台湾| 好紧好爽好深再快点av在线| 国产亚洲精品第一综合麻豆| 精品国精品国产自在久国产应用| 欧美一区内射最近更新| 国产精品一区二区久久乐下载| 动漫精品无码h在线观看| 午夜伦费影视在线观看| 好吊色欧美一区二区三区四区 | 国产 精品 自在 线免费 | 欧美做受视频播放| 日韩精品无码熟人妻视频| 18禁止看的免费污网站| 亚洲熟妇无码八av在线播放| av无码国产在线观看岛国| 亚洲精品久久久久中文字幕一福利| 欧美综合在线激情专区| 精品无码无人网站免费视频| 国产肉体xxxx裸体137大胆| 成人网站色52色在线观看| 免费的污污的网站在线观看| 日日噜噜噜噜夜夜爽亚洲精品| 日韩中文字幕在线一区二区三区 | 国产午夜草莓视频在线观看| 国产3p露脸普通话对白| 成人精品视频一区二区| 四虎一区二区成人免费影院网址| 中文字幕有码无码人妻在线| 大又大又粗又硬又爽少妇毛片| 国产精品亚洲欧美大片在线看| 亚洲在av人极品无码| 国产美熟女乱又伦av果冻传媒| 国产精品区av| 性按摩xxxx在线观看| 扒开双腿猛进入喷水高潮叫声| 日本一卡二卡四卡无卡国产| 免费中文字幕日韩欧美| 国产白丝无码免费视频|