在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL18RAP Antibody

IL18RAP Antibody

  • 中文名稱(chēng)：
    IL18RAP兔多克隆抗體
  • 貨號(hào)：
    CSB-PA584612
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-3: RAW264.7 cells, human liver cancer tissue, SP20 cell, Primary antibody: CSB-PA584612(IL18RAP Antibody) at dilution 1/650, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    IL18RAP; IL1R7; Interleukin-18 receptor accessory protein; IL-18 receptor accessory protein; IL-18RAcP; Accessory protein-like; AcPL; CD218 antigen-like family member B; CDw218b; IL-1R accessory protein-like; IL-1RAcPL; Interleukin-1 receptor 7; IL-1R-7; IL-1R7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta; IL-18R-beta; IL-18Rbeta; CD antigen CD218b
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human IL18RAP
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation. May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable).
  • 基因功能參考文獻(xiàn)：
    1. Polymorphisms in IL18RAP influence susceptibility to obesity. We demonstrated that the A allele in rs7559479 increases MIR136 binding, which regulates IL-18 system activity. PMID: 29146643
    2. An association of IL18RAP single nucleotide polymorphism rs2058660 with Behcet's disease, but not Vogt-Koyanagi-Harada disease in Han Chinese. PMID: 27775096
    3. These findings suggested that IL-18RAP rs917997, IL-32 rs2015620, IL-22 rs1179251, and interactions between these polymorphisms and H. pylori infection were associated with risks of gastric lesions PMID: 26358252
    4. some SNPs of ST2-IL18R1-IL18RAP gene cluster might increase the risk of susceptibility of Graves' disease (GD) and Hashimoto's thyroiditis (HT) in Chinese Han population. PMID: 26566691
    5. This meta-analysis provides robust estimates that IL18RAP rs917997 and chemokine (C-C motif) receptor 3 rs6441961 are potential risk factors for celiac disease in European populations. PMID: 26289103
    6. results demonstrate clear functional consequences of the rs917997 risk polymorphism; this polymorphism leads to a loss-of-function through decreased IL-18RAP, IL-18R1, and IL-1R1 protein expression, which impairs autocrine IL-18 and IL-1 signaling PMID: 24842757
    7. The SNP modified IL18RAP surface protein expression by NK cells. PMID: 23891168
    8. Data indicate that MyD88 works together with the IL-1/IL-18 receptors, can interact with two distinct sorting adaptors, TRAM and Mal, in a conserved manner. PMID: 22685567
    9. Data suggest that IL-18RAP and IL-18R1 single-nucleotide polymorphisms identify African-American infants at risk for bronchopulmonary dysplasia. PMID: 22289858
    10. IL-18, IL-18 receptor alpha, and CD48 complex formation via glycosylphosphatidylinositol anchor glycan triggers binding to IL-18 receptor beta, and thereby induces intracellular signal transduction and IFN-gamma production. PMID: 15760905
    11. Truncated forms of IL-18RAP may be involved in the complex mechanism of IL-18 activity regulation. PMID: 17897836
    12. Variations in IL18RAP is associated with celiac disease PMID: 18311140
    13. CARD9 and IL18RAP are IBD loci important in innate immunity in the predisposition to both CD and UC. PMID: 18439550
    14. study provides suggestive evidence for associations of SNPs in the IL1RL1 gene and adjacently located family members IL18R1 and IL18RAP with asthma and atopy in 2 independent Dutch asthma populations PMID: 18774397
    15. IL18RAP is a novel predisposing gene for coeliac disease. PMID: 19103669
    16. Our analysis suggests that the variability of IL18RAP genes is unlikely to contribute to modulate the risk of cardiovascular disease PMID: 19473509
    17. Investigated the regions 2q12 (IL18RAP) and 3p21 (CCR3)in regards to celiac disease risk in the Spanish population.Two SNPs, rs917997 (2q12) and rs6441961 (3p21), were genotyped; Assoc'n was found w/rs6441961, a non-sign. result was obtained for rs917997. PMID: 19542083
    18. The mechanism of the impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis involves a defect in IL-18Rbeta phosphorylation. PMID: 19714583

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Interleukin-1 receptor family
  • 組織特異性：
    Detected in adrenal gland, bone marrow, brain, fetal brain, fetal liver, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, prostate, salivary gland, skeletal muscle, spinal cord, testis, thymus, thyroid, trachea and uterus. Strongly expre
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 5989

    OMIM: 604509

    KEGG: hsa:8807

    STRING: 9606.ENSP00000264260

    UniGene: Hs.158315



主站蜘蛛池模板： 国产精品无码av片在线观看播| 天天摸天天做天天爽| 亚洲伊人久久综合影院| 成片免费观看视频大全| 欧美成 人影片 aⅴ免费观看 | 伊人久久精品无码麻豆一区| 免费看又黄又无码的网站| 99国产精品久久久久久久成人 | 国产三级农村妇女在线 | 水蜜桃亚洲一二三四在线| 亚洲人成亚洲精品| 国产精品乱子伦xxxx裸| 国产aⅴ精品一区二区三区| 中文无码av一区二区三区| 日日碰狠狠躁久久躁96avv| 中文字幕+乱码+中文乱码www | 日本免费一区二区三区视频观看 | 精品国产综合成人亚洲区| 亚洲中文字幕人成乱码| 在线精品自偷自拍无码| 久久久久久久久久久国产| 亚洲日韩欧美一区久久久久我| 任我爽橹在线精品视频| 夜夜添无码一区二区三区| 欧美牲交a欧美在线| 精品久久久久久中文墓无码| 老头把我添高潮了a片| 国产艳妇av在线观看果冻传媒| 日韩国产亚洲欧美中国v| 久久天天躁夜夜躁狠狠躁| 久久av无码αv高潮αv喷吹| 少妇特殊按摩高潮惨叫无码| 国产成人18黄网站在线观看| 大肉大捧一进一出好爽视频mba| 99在线精品免费视频| 137裸交肉体摄影| 国农村精品国产自线拍| 亚洲日韩乱码久久久久久| 无遮挡午夜男女xx00动态| 伊人久久大香线蕉av五月天| 亚洲日韩成人无码|