在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. IL17RC Antibody

IL17RC Antibody

  • 中文名稱(chēng)：
    IL17RC兔多克隆抗體
  • 貨號(hào)：
    CSB-PA645798
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tosil tissue using CSB-PA645798(IL17RC Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    IL17RC antibody; UNQ6118/PRO20040/PRO38901Interleukin-17 receptor C antibody; IL-17 receptor C antibody; IL-17RC antibody; Interleukin-17 receptor homolog antibody; IL17Rhom antibody; Interleukin-17 receptor-like protein antibody; IL-17RL antibody; ZcytoR14 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Fusion protein of Human IL17RC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:5000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA. Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA. Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway. Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression. Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation. Primarily induces neutrophil activation and recruitment at infection and inflammatory sites. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers.; Receptor for both IL17A and IL17F.; Does not bind IL17A or IL17F.; Does not bind IL17A or IL17F.; Receptor for both IL17A and IL17F.
  • 基因功能參考文獻(xiàn)：
    1. Five SNPs in the IL17RC (and COL6A1) genes were found to be associated with susceptibility to ossification of the posterior longitudinal ligament in Han Chinese patients. PMID: 29764467
    2. IL-17RC rs708567 polymorphism in A/A genotype, G/G genotype, and G/a genotype did not seem to influence RA susceptibility in Tunisian population. PMID: 29584788
    3. methylation of IL17RC could play as a marker in CNV and degeneration of RPE cells in vitro. PMID: 26731132
    4. Interleukin 17A (IL17a) and interleukin-23 (IL-23) - dependent interleukin-17 receptor C (IL-17RC) are expressed by sputum and neutrophils in deltaF508-CFTR protein (F508del) cystic fibrosis patients. PMID: 27155366
    5. human IL-17RC is essential for mucocutaneous immunity to C. albicans but is otherwise largely redundant. PMID: 25918342
    6. results suggested a potential involvement of IL-17RC+CD8+ T cells in pathogenesis of ocular sarcoidosis PMID: 24885153
    7. IL-17RC predisposes to the development of adolescent idiopathic scoliosis in a Chinese Han population. PMID: 22999050
    8. Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS. PMID: 22744455
    9. IL-17 and its receptor IL-17RC are involved in rheumatoid arthritis synovial fluid-mediated chemotaxis in human lung microvascular endothelial cell culture. PMID: 20173024
    10. IL-17RL exists as multiple isoforms due to extensive alternative splicing. Changes in RNA IL-17RL splicing occur in advanced cancers. PMID: 16688746
    11. The biologic activity of IL-17 is dependent on a complex composed of receptors IL-17RA and IL-17RC. PMID: 16785495
    12. IL-17RC functions as a receptor for both IL-17A and IL-17F; a soluble version of this protein should be an effective antagonist of IL-17A and IL-17F mediated inflammatory diseases. PMID: 17911633
    13. IL-17A-induced IL-6, IL-8, and CCL20 secretion was dependent on both IL-17RA and IL-17RC, which are overexpressed in RA patients. PMID: 18097068
    14. Interleukin-17F is inhibited by the IL-17RC receptor, a combination of soluble IL-17RA/IL-17RC receptors is required for inhibition of the IL-17F/IL-17A activity. PMID: 18684971

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Candidiasis, familial, 9 (CANDF9)
  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type I membrane protein. Note=Soluble isoforms may be produced.
  • 組織特異性：
    Expressed in prostate, skeletal muscle, kidney and placenta (at protein level). Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate. Also detected in thyroid, trachea and adrenal gland. Low expressio
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 18358

    OMIM: 610925

    KEGG: hsa:84818

    STRING: 9606.ENSP00000295981

    UniGene: Hs.129959



主站蜘蛛池模板： 亚洲伊人成无码综合影院| 亚洲精品一区国产欧美| 久久青青草原国产毛片| 爆乳高潮喷水无码正在播放 | 久艹视频免费看| 丝袜熟女国偷自产中文字幕亚洲| 国产精品二区一区二区aⅴ污介绍| 激情综合色综合啪啪五月丁香搜索 | 69久久精品无码一区二区无码| 国产一区二区三区免费观看在线| 春色校园综合人妻av| 日本久久综合久久综合| 亚洲人成小说网站色在线观看| 日本乱偷人妻中文字幕| 成人免费的视频| 欧美激情一区二区成人| 春色校园亚洲愉拍自拍| 成人网站在线进入爽爽爽| 久久视频在线视频| 国语自产拍在线视频中文| 国产乱人伦偷精精品视频| 业余 自由 性别 成熟偷窥| 亚洲欧美日韩国产综合v| 青青草国产三级精品三级 | 久久国产超碰女女av| 日本阿v网站在线观看中文| 久久人人爽人人爽人人av东京热 | 337p日本欧洲亚洲大胆艺术图| 一本一久本久a久久精品综合| 忍不住的亲子中文字幕| 国产一卡三卡四卡无卡精品| 日本一丰满一bbw| 国产精品久久无码一区| 精品国产午夜肉伦伦影院| 国产欧美日韩综合在线成| 99re在线播放| 人人妻人人澡人人爽人人dvd| 午夜福利无遮挡十八禁视频| 粉嫩大学生无套内射无码卡视频| 综合 欧美 亚洲日本| 国产精品激情欧美可乐视频|