在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL17RB Antibody

  • 中文名稱:
    IL17RB兔多克隆抗體
  • 貨號:
    CSB-PA882088ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA882088ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA882088ESR2HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IL17RB Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    IL17RB antibody; CRL4 antibody; EVI27 antibody; IL17BR antibody; UNQ2501/PRO19612 antibody; Interleukin-17 receptor B antibody; IL-17 receptor B antibody; IL-17RB antibody; Cytokine receptor-like 4 antibody; IL-17 receptor homolog 1 antibody; IL-17Rh1 antibody; IL17Rh1 antibody; Interleukin-17B receptor antibody; IL-17B receptor antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interleukin-17 receptor B protein (18-292AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.
  • 基因功能參考文獻:
    1. The expression of HOXB13, IL17BR, and mammaglobin 1 in sentinel lymph nodes predict the outcome of primary breast cancer patients. PMID: 29729704
    2. The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID: 27146881
    3. IL-17RB can enhance thyroid cancer cell invasion and metastasis via ERK1/2 pathway-mediated MMP-9 expression, suggesting that IL-17RB may act as a potential therapeutic target for thyroid cancer therapy. PMID: 28715683
    4. IL-4 signaling up-regulates the IL-25 axis in human monocytic cells, and IL-25 may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation. PMID: 28421819
    5. Our results identify a biochemical role for WDTC1 and extend the functional range of the CRL4 complex to the suppression of fat accumulation. PMID: 27113764
    6. Atopic IL-17RB(+) DCs can be up-regulated by LPS and promote a TH2-type response, implying that the IL-25/IL-17RB pathway may represent a potential molecular mechanism underlying the regulation of ECs on DCs in allergic airway disease. PMID: 28132739
    7. IL-17RB(+) granulocytes and T2M cells from peripheral blood were increased in subjects with asthma, and the 2 cell types correlated with degree of airflow obstruction. PMID: 27979026
    8. collectively, this study uncovers a new role for CRL4CDT2 in protecting genomic integrity against replication stress via regulated proteolysis of PCNA-associated SDE2 and provides insights into how an integrated UBL domain within linear polypeptide sequence controls protein stability and function. PMID: 27906959
    9. This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID: 28160754
    10. The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio PMID: 26728744
    11. Therefore, IL-17E/IL-17RB signaling represents a potential therapeutic target for treatment of hepatocellular carcinoma PMID: 27000993
    12. GS is acetylated at lysines 11 and 14, yielding a degron that is necessary and sufficient for binding and ubiquitylation by CRL4(CRBN) and degradation by the proteasome. PMID: 26990986
    13. Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID: 26285835
    14. IL-17RB has an essential role in pancreatic cancer growth, invasion, and metastasis. PMID: 25732306
    15. High IL17RB expression is associated with breast cancer. PMID: 23497539
    16. Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID: 23851503
    17. The increased IL-25 levels in plasma and the expression of IL-17RA and IL-17RB on eosinophils in allergic asthma patients suggests that IL-25 may activate eosinophils during allergic inflammation. PMID: 24247484
    18. Allergen provocation induces functionally relevant, increased expression of IL-25 and its receptor in the asthmatic bronchial mucosa and dermis of sensitized atopic subjects. PMID: 21570719
    19. In summary we established a new mechanism of IL17RB regulation-Smurf2 dependent degradation of its adaptor protein DAZAP2. PMID: 22070932
    20. The present study identified upregulation of IL17RB during natural allergen exposure in patients with seasonal allergic rhinitis (SAR). PMID: 21252617
    21. Results indicate that IL17RB may be the only gene expressed in CD4+ T cells whose transcript measurement is correlated with the variation in IgE level in asthmatics, but correlation between IL17RB and IgE was restricted to males only. PMID: 21473777
    22. Increased expression of IL-17RB on allergen-challenged basophil is regulated by IL-3, inhibits apoptosis and promotes IgE-mediated degranulation of basophils PMID: 20545698
    23. The IL17RB protein expression increases during disease progression of breast cancer to hormonal therapy. PMID: 16609001
    24. HOXB13 and IL17BR has a role in progression of early-stage breast cancer PMID: 17008703
    25. HOXB13 and IL17BR have roles in breast cancer PMID: 17453342
    26. An index composed of inherited (CYP2D6) and tumor (HOXB13/IL17BR) gene variation identifies patients with varying degrees of resistance to tamoxifen. PMID: 18794098
    27. Our results revealed that the IL-17RB +5661 G>A locus has a dominant and protective genetic effect on the development of asthma. PMID: 19118269

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.
  • 組織特異性:
    Expressed in several endocrine tissues, mostly in fetal and adult liver, kidney, pancreas, testis, colon, brain and small intestine; not detected in peripheral blood leukocytes, lymphoid organs, and most cell lines.
  • 數據庫鏈接:

    HGNC: 18015

    OMIM: 605458

    KEGG: hsa:55540

    STRING: 9606.ENSP00000288167

    UniGene: Hs.654970



主站蜘蛛池模板: 884aa四虎影成人精品| 亚洲乱码卡一卡二卡新区中国| 99精品日本二区留学生| 免费无码又爽又刺激高潮的app | 国产精品一区二区在线观看| 中文久久乱码一区二区| 久久国产精品一国产精品| 98视频精品全部国产| 97无码免费人妻超级碰碰碰碰| 国产乱子伦在线一区二区| 欧美乱妇高清无乱码| 三级在线看中文字幕完整版| 中国内射xxxx6981少妇| 久久精品aⅴ无码中文字字幕| 人妻少妇偷人精品视频| 丰满爆乳无码一区二区三区| 国产精品久久久久久免费软件| 99久久国产成人免费网站| 国产精品无码午夜福利| 欧洲熟妇性色黄| 人人玩人人添人人澡超碰偷拍 | 亚洲中文字幕av每天更新 | 一区一区三区产品乱码亚洲| 精品一二三区久久aaa片| 97精品人人a片免费看| 无码人妻丰满熟妇区五十路| 亚洲精品国产品国语原创| 男女啪啪高清无遮挡免费| 香蕉影院在线观看| 国产真实野战在线视频| 无码人妻一区二区中文| 已婚少妇美妙人妻系列| 日韩一区二区三区无码影院| 婷婷五月俺也去人妻| 午夜福利日本一区二区无码| 国产亚洲精品久久久久蜜臀| 欧美gv在线观看| 寂寞人妻瑜伽被教练日| 无人区乱码区1卡2卡三卡网站| 香港三级精品三级在线专区| 欧美疯狂性受xxxxx喷水|