在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IL10RB Antibody

  • 中文名稱:
    IL10RB兔多克隆抗體
  • 貨號:
    CSB-PA011582GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cd210 antibody; CDw210b antibody; CRF2 4 antibody; CRF2-4 antibody; CRFB4 antibody; Cytokine receptor class II antibody; Cytokine receptor class II CRF2 4 antibody; Cytokine receptor class-II member 4 antibody; Cytokine receptor family 2 member 4 antibody; Cytokine receptor family II member 4 antibody; D21S58 antibody; D21S66 antibody; I10R2_HUMAN antibody; IL-10 receptor subunit beta antibody; IL-10R subunit 2 antibody; IL-10R subunit beta antibody; IL-10R2 antibody; IL-10RB antibody; IL10R2 antibody; IL10RB antibody; Interleukin 10 receptor beta antibody; Interleukin-10 receptor subunit 2 antibody; Interleukin-10 receptor subunit beta antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human IL10RB
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state.
  • 基因功能參考文獻:
    1. IFN-lambda4 suppressed HIV infection of macrophages. This IFN-lambda4-mediated HIV inhibition was compromised by the antibodies against IFN-lambda receptor complex, IFN-lambdaR1/IL-10R2. PMID: 30247785
    2. IL-10 and IL-10R gene polymorphisms may not contribute to the susceptibility to MM but may be associated with the severity and prognosis of MM. In particular, IL-10RB K47E polymorphism may contribute to the poor prognosis of MM patients treated with thalidomide and/or bortezomib. PMID: 27405747
    3. systemic mRNA expression of IL10RB strongly differentiated children who failed to achieve asthma control with triamcinolone administration PMID: 27665382
    4. IL10R2 Overexpression promotes IL22/STAT3 signaling in colorectal carcinogenesis. PMID: 26130064
    5. High IL10RB expression is associated with diffuse large B-cell lymphoma. PMID: 25733167
    6. PAPL, IL10RB and DEPDC5 polymorphisms have an impact on progression of hepatitis B virus-related liver disease. PMID: 25032264
    7. Results show that the distribution of IL10RB and IL28RA genotypes among the Hepatitis C virus-infected and control groups did not differ significantly. PMID: 24144988
    8. Mutations in the IL10RB gene is associated with ulcerative colitis. PMID: 24216686
    9. IL-10RB rs2834167 (A/G) polymorphism may be a potential biomarker for susceptibility to systemic lupus erythematosus. PMID: 23749100
    10. Case Report: pediatric ulcerative colitis patient compound heterozygote for the IL10RB E47K polymorphism, inherited from his father. PMID: 24379584
    11. IL10RB polymorphisms are associated with Crohn's disease. PMID: 22550014
    12. distinct receptor complex that is utilized by all three IFN-lambda proteins for signaling and is composed of two subunits, a receptor designated CRF2-12 (also designated as IFN-lambdaR1) and a second subunit, CRF2-4 (also known as IL-10R2) PMID: 12483210
    13. sensitivity to recombinant interleukin-26(IL-26) of various cell lines strictly correlated with the expression of IL-20 receptor 1 and blocking antibodies against either IL-10 receptor 2 or IL-20 receptor 1 inhibited IL-26-dependent signal transduction PMID: 15178681
    14. These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc. PMID: 18588853
    15. The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID: 18675824
    16. gene polymorphism in combination with IL-10 gene polymorphism is assiociated with GvHD in HLA-identical donor-recipient pairs PMID: 19409109
    17. Inhibition of S100A11 gene expression impairs the ability of keratinocytes to control vaccinia virus replication via downregulation of IFN-lambda receptor IL-10R2. PMID: 19577285
    18. The association with the susceptibility to HBV infection was only observed for IL10RB K47E when we compared the individuals with persistent HBV infection through nonmaternal transmission to the controls with asymptomatic self-limited HBV infection. PMID: 19714778

    顯示更多

    收起更多

  • 相關疾病:
    Inflammatory bowel disease 25 (IBD25)
  • 亞細胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Type II cytokine receptor family
  • 數據庫鏈接:

    HGNC: 5965

    OMIM: 123889

    KEGG: hsa:3588

    STRING: 9606.ENSP00000290200

    UniGene: Hs.654593



主站蜘蛛池模板: 国产又大又粗又爽的毛片| 扒开双腿疯狂进出爽爽爽视频| 黑人玩弄出轨人妻松雪| 无码人妻aⅴ一区二区三区有奶水| 综合自拍亚洲综合图区欧美| 婷婷综合缴情亚洲| 欧美丰满熟妇xxxx性| 高潮添下面视频免费看| 国产人妻大战黑人第1集| 少妇人妻精品无码专区视频| 久久久久高潮综合影院| 日韩av无码一区二区三区| 欧洲vat一区二区三区| 中文字幕久久精品无码| 精品亚洲国产成人av| 欧美丰满少妇xxxx性| 少妇spa推油被扣高潮| 欧美最新精品videossexohd| 久久久久成人精品免费播放动漫| 亚洲一卡一卡二新区无人区| 超caopor在线公开视频| 欧美真人做爰在线观看| 狼色精品人妻在线视频| 一本大道一卡2卡三卡4卡国产| 天堂久久久久va久久久久| 青青草大香焦在线综合视频| 亚洲国产精品久久亚洲精品| 99精品产国品一二三产区| 日本一区午夜艳熟免费| 色综合久久无码中文字幕| 日本久久综合久久综合| 丰满的少妇hd高清中文字幕| 中文字幕亚洲无线码| 成年无码动漫av片在线观看羞羞| 四虎国产精品永久地址入口| 极品人妻videosss人妻| 色欲麻豆国产福利精品| 国产精品免费观看调教网| 最新亚洲人成无码网站| 人妻 丝袜美腿 中文字幕| 久久三级中文欧大战字幕|