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  4. IKZF4 Antibody

IKZF4 Antibody

  • 中文名稱：
    IKZF4兔多克隆抗體
  • 貨號：
    CSB-PA050030
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    IKZF4
  • 別名：
    EOS antibody; Eos protein antibody; IKAROS family zinc finger 4 (Eos) antibody; IKAROS family zinc finger 4 antibody; Ikaros family zinc finger protein 4 antibody; IKZF4 antibody; IKZF4_HUMAN antibody; KIAA1782 antibody; Zinc finger protein Eos (IKAROS family zinc finger protein 4) antibody; Zinc finger protein Eos antibody; Zinc finger protein; subfamily 1A; 4 (Eos) antibody; Zinc finger protein; subfamily 1A; member 4 antibody; Zinc finger transcription factor Eos antibody; ZNFN1A4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human Eos.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1.
  • 基因功能參考文獻：
    1. IKZF4 polymorphism (rs1701704) was strongly associated with insulin autobody positivity at the time of type 1 diabetes diagnosis PMID: 23721563
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Ikaros C2H2-type zinc-finger protein family
  • 組織特異性：
    Highly expressed in skeletal muscle, low levels of expression in heart, thymus, kidney, liver, and spleen. Expressed in the hematopoietic cell lines MOLT-4, NALM-6 and K-562. Highly expressed in THP-1 and M-07e cell lines, which have characteristics of my
  • 數據庫鏈接：

    HGNC: 13179

    OMIM: 606239

    KEGG: hsa:64375

    STRING: 9606.ENSP00000262032

    UniGene: Hs.553221



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