在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IGBP1 Antibody

  • 中文名稱:
    IGBP1兔多克隆抗體
  • 貨號:
    CSB-PA011082GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Alpha 4 antibody; B cell signal transduction molecule alpha 4 antibody; B-cell signal transduction molecule alpha 4 antibody; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ) antibody; bA351K23.1 antibody; CD79a binding protein 1 antibody; CD79a-binding protein 1 antibody; IBP 1 antibody; IBP1 antibody; IGBP 1 antibody; Igbp1 antibody; IGBP1_HUMAN antibody; Immunoglobulin (CD79A) binding protein 1 antibody; Immunoglobulin binding protein 1 antibody; Immunoglobulin-binding protein 1 antibody; Protein alpha 4 antibody; Protein alpha-4 antibody; Protein phosphatase 2/4/6 regulatory subunit antibody; Protein phosphatase 2A regulatory subunit alpha 4 antibody; Renal carcinoma antigen NY REN 16 antibody; Renal carcinoma antigen NY-REN-16 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human IGBP1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits.
  • 基因功能參考文獻:
    1. Knockdown of Alpha4 preferentially impacts the expression of PP4c and PP6c compared to expression levels of PP2Ac. PMID: 27169767
    2. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC)-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A) through alpha4 phosphoprotein by caveolin-1 (cav-1). PMID: 26876307
    3. MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac in X-linked Opitz syndrome. PMID: 25207814
    4. alpha4 is an important regulatory molecule of apoptosis and Bcl-xL phosphorylation induced by BCR crosslinking. PMID: 25876659
    5. the alpha4 N-terminus binding to endogenous PP2Ac and PABP, and the C-terminus to EDD, is reported. PMID: 24145130
    6. A potential important role of alpha4 in control of cell migration and/or invasion via the regulation of E-cadherin expression in bladder urothelial carcinoma. PMID: 24388773
    7. The structure of alpha45 reveals two distinct surfaces, one that can interact with a negatively charged surface, which is present on PP2A, and one that interacts with the Bbox1 domain of MID1. PMID: 22194938
    8. alpha4 is highly expressed in carcinogen-transformed human cells and primary human cancers. PMID: 21339737
    9. both the C-terminal Mid1-binding domain and the PP2Ac-binding determinants are required for Alpha4-mediated protection of PP2Ac from polyubiquitination and degradation. PMID: 21454489
    10. IGBP-1 is expressed universally in advanced lung adenocarcinomas, and its overexpression is significantly related to outcome. PMID: 21355954
    11. Data show that in addition to PP2Ac, alpha4 interacts with EDD and PABP, suggesting its involvement in multiple steps in the mTOR pathway that leads to translation initiation and cell-cycle progression. PMID: 20544796
    12. Alpha 4, a regulatory subunit of PP2-type phosphatases and a key component of the rapamycin-sensitive signaling pathway, has been indentified as a strong interactor of both MID1 and MID2. PMID: 11806752
    13. alpha4 C-terminal deletion mutants at 222 (alpha4Delta222), 236 (alpha4Delta236) & 254 (alpha4Delta254) were expressed. alpha4Delta222 & alpha4Delta236 possess a higher content of alpha-helix, indicating that C-terminal region is less structured. PMID: 16517231
    14. a new role for mTOR and alpha4/PP2Ac in the control of STAT1 nuclear content, and the expression of interferon-gamma-sensitive genes involved in immunity and apoptosis. PMID: 19553685

    顯示更多

    收起更多

  • 相關疾病:
    Mental retardation, X-linked, syndromic, 28 (MRXS28)
  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    IGBP1/TAP42 family
  • 組織特異性:
    Ubiquitously expressed with highest levels in heart, skeletal muscle and pancreas.
  • 數據庫鏈接:

    HGNC: 5461

    OMIM: 300139

    KEGG: hsa:3476

    STRING: 9606.ENSP00000348784

    UniGene: Hs.496267



主站蜘蛛池模板: 中文字幕av无码免费一区| 国产精品无码电影在线观看| 国产香蕉尹人在线视频你懂的| 国精品人妻无码一区免费视频电影| 亚洲精品国产一区二区图片| 漂亮人妻洗澡被公强 日日躁| 真人与拘做受免费视频| 国产又色又爽无遮挡免费| av无码一区二区二三区1区6区| 在线精品亚洲第一区焦香| 亚洲性猛交xxxx| 国产免费视频| 高清国产一区二区三区在线| av综合网男人的天堂| 一本一本久久a久久精品综合麻豆| 人人妻人人澡人人爽| 久久99国产精品成人| 日本一卡2卡三卡4卡免费网站 | 激情久久av一区av二区av三区| 日本japanese丰满白浆 | 丰满岳乱妇一区二区三区| 美女被张开双腿日出白浆| 精品伊人久久久大香线蕉下载| 午夜成人理论无码电影在线播放| 么公的好大好硬好深好爽视频| 亚洲国产精品久久久久婷婷软件| 四虎永久在线精品免费无码| 亚洲色欲色欲www在线观看| 精品人伦一区二区三区蜜桃免费| 中文字幕乱码一区av久久| 亚洲国产成人精品无码区二本| 国产真人做爰视频免费| 精品乱码一区二区三区四区| 人妻少妇乱子伦无码专区| 国语对白嫖老妇胖老太| 天天摸天天做天天爽水多| 狠狠色噜噜狠狠狠狠97首创麻豆| 亚洲欧美另类成人综合图片| 少妇极品熟妇人妻200片| 国产成人无码一区二区三区在线| 日日躁夜夜躁狠狠躁|