在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IFNGR2 Antibody

  • 中文名稱:
    IFNGR2兔多克隆抗體
  • 貨號:
    CSB-PA149561
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA149561(IFNGR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA149561(IFNGR2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: Mouse muscle tissue, Primary antibody: CSB-PA149561(IFNGR2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    IFNGR2; IFNGT1; Interferon gamma receptor 2; IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1; AF-1; Interferon gamma receptor beta-chain; IFN-gamma-R-beta; Interferon gamma transducer 1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthetic peptide of Human IFNGR2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Associates with IFNGR1 to form a receptor for the cytokine interferon gamma (IFNG). Ligand binding stimulates activation of the JAK/STAT signaling pathway. Required for signal transduction in contrast to other receptor subunit responsible for ligand binding.
  • 基因功能參考文獻:
    1. The study identified an SNP rs9978223 on IFNGR2 gene, associated with increased risk in acute myocardial infarctionpatient from India. PMID: 29434065
    2. In the Title. PMID: 27522156
    3. A crystal structure of the extracellular part of human interferon-gamma receptor 2 (IFNGR2) was solved by molecular replacement at 1.8 A resolution. PMID: 27599734
    4. The IFNGR2Q64R polymorphism is correlated with male sex and paranoid schizophrenia in Tunisians. PMID: 27563937
    5. IFN-gammaR2 T168N mutant diffusion is confined by distinct actin nanodomains where conformational changes required for JAK/STAT activation by IFN-gamma could not occur. Removing IFN-gammaR2 T168N-bound galectins restored lateral diffusion in lipid nanodomains and JAK/STAT signaling in patient cells, whereas adding galectins impaired these processes in control cells. PMID: 27499022
    6. Fatal hemophagocytic lymphohistiocytosis has been described in two unrelated pediatric patients with underlying IFNGR2 deficiency. PMID: 25592983
    7. The expression of IFNGR2 was significantly higher in patients with RA compared with control subjects and was significantly higher in patients in whom radiographic damage was more severe. PMID: 25708927
    8. This is the first study that shows an association between SNPs and liver fibrosis in the general population PMID: 25301852
    9. We report a molecular study of the two known patients with autosomal recessive, partial interferon-gamma receptor (IFN-gammaR)2 deficiency PMID: 23963039
    10. IFN-gammaR2-deficient monocytes induce a higher percentage of IL-17(+) cells from both healthy and IFN-gammaR2-deficient CD4(+) T cells. PMID: 23459074
    11. IFNGR2 haploinsufficiency may underlie clinical tuberculosis in children living in areas of endemic disease. PMID: 23161749
    12. JAK2 is a critical factor that stabilizes IFN-gammaR2 surface expression in Th17 cells from AMS patients, making them sensitive to IFN-gamma. PMID: 22219326
    13. We conclude that the polymorphisms of IFNGR2 may confer resistance to the TB development of newly infected individuals PMID: 22057826
    14. Data indicate that perturbation of IFN-gammaR2 internalization by mutating the LI(255-256) motif induces a timely coordinated activation of IFN-gamma/STAT1 signaling pathways that leads to the apoptosis of T cells. PMID: 20709103
    15. HBV viraemia appears to have substantial heritability and polymorphisms in the IFNGR2 gene appear to be associated with the variability of viraemia. PMID: 20980339
    16. between the two IFNg receptors, IFNgR2 expression appears to be the deciding factor that controls the way in which target cells physiologically respond to IFNgamma. PMID: 20587546
    17. These results suggesedt that the microglial and oligodendrocytic expression levels of IFN-gamma-R2 are much lower than the astrocytic expression levels in the human CNS. PMID: 20554027
    18. The existence of abnormalities in the intracellular processing and protein expression of the IFN-gamma R2 in response to specific stimuli such as IFN-gamma and M. leprae membrane proteins in adherent cells of LL patients. PMID: 20039824
    19. Results show that the discovery of the anti-Bax activity of the cytoplasmic domain of IFNgammaR2 may shed new light on the mechanism of how cell death is controlled by IFNgamma and Bax. PMID: 19657228
    20. Phages displaying fusion proteins with full-length PNRC2 (proline-rich nuclear receptor co-regulatory protein 2), already shown to be a cofactor for other nuclear receptors, and with a polypeptide of the bHLH corepressor TLE1 bound to AF-1. PMID: 14651967
    21. In pre eclampsia IFN-gamma R2 protein expression mimicked that in early placental development. PMID: 15585559
    22. Higher frequency of +874T interferon gamma, both in hetero and in homozygosis and mostly whether simultaneous, plays a role in predisposing to gluten intolerance and an increased risk for coeliac disease. PMID: 15979955
    23. Two IFN-gammaR2 chains interact through species-specific determinants in their extracellular domains. Finally, these determinants also participate in the interaction of IFN-gammaR2 with IFN-gammaR1. PMID: 16467876
    24. interferon-gamma (IFN-gamma) receptor PMID: 16467883
    25. Single Nucleotide Polymorphisms in IFNGR2 is associated with gastric cancer PMID: 16885196
    26. Therefore, our results suggest that the interaction between Sirt2 and 14-3-3 beta/gamma is a novel mechanism for the negative regulation of p53 beside the well-characterized Mdm2-mediated repression. PMID: 18249187
    27. No significant change was demonstrated in the expression of IFN-gamma receptor beta-chain on surfaces of alveolar macrophages acquired from smokers. PMID: 19269302

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency 28 (IMD28)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm.
  • 蛋白家族:
    Type II cytokine receptor family
  • 組織特異性:
    Expressed in T-cells (at protein level).
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5440

    OMIM: 147569

    KEGG: hsa:3460

    STRING: 9606.ENSP00000290219

    UniGene: Hs.634632



主站蜘蛛池模板: av在线播放无码线| 99在线精品视频观看免费| 在线观看片免费人成视频无码| 亚洲精品毛片一区二区三区| 国产老熟女伦老熟妇露脸| 起碰免费公开97在线视频| 久久不见久久见免费影院www日本| 偷窥 亚洲 另类 图片 熟女| 超碰cao已满18进入离开官网| 久久国产精品福利一区二区三区| 无码无套少妇18p在线直播 | 国产亚洲精品久久久久久入口| 中文字幕一区日韩精品| 中文国产成人精品久久app| 国产成人午夜高潮毛片| 国产私人尤物无码不卡| 国产精品自产拍在线18禁| 青楼妓女禁脔道具调教sm| 色综合久久网| 免费三级现频在线观看免费| 欧美亚洲国产精品久久蜜芽| 国产在线清纯极品美女援交| 99久久精品视香蕉蕉| 国产午夜精品一区理论片飘花 | 亚洲国产欧美中文丝袜日韩| 日韩少妇内射免费播放18禁裸乳| 欧美在线 | 亚洲| 狠狠精品久久久无码中文字幕| 97夜夜澡人人双人人人喊| 黑人巨茎大战白人美女| av在线亚洲男人的天堂| 亚洲午夜成人精品无码app| 亚洲欧美日韩综合俺去了| 国产精品h片在线播放| av无码小缝喷白浆在线观看| 日本一区二区无卡高清视频| 国产无吗一区二区三区在线欢 | 51视频国产精品一区二区| 97人洗澡从澡人人爽人人模| 天堂网在线www中文| 蜜桃视频无码区在线观看|