在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

IFIT2 Antibody, FITC conjugated

  • 中文名稱:
    IFIT2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA011021LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) IFIT2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    IFIT2
  • 別名:
    CIG-42 antibody; cig42 antibody; G10P2 antibody; GARG 39 antibody; Glucocorticoid attenuated response gene 39 antibody; IFI 54 antibody; IFI 54K antibody; IFI-54K antibody; IFI54 antibody; IFIT 2 antibody; IFIT-2 antibody; IFIT2 antibody; IFIT2_HUMAN antibody; Interferon induced 54 kDa protein antibody; Interferon induced protein 54 antibody; Interferon induced protein with tetratricopeptide repeats 2 antibody; Interferon, alpha inducible protein (MW 54kD) antibody; Interferon-induced 54 kDa protein antibody; Interferon-induced protein with tetratricopeptide repeats 2 antibody; ISG 54 K antibody; ISG 54K antibody; ISG-54 K antibody; ISG54 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Interferon-induced protein with tetratricopeptide repeats 2 protein (130-265AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.
  • 基因功能參考文獻:
    1. The results of the present study revealed that the inhibition of proteasome activity blocked the degradation of IFIT2 and promoted the aggregation of IFIT2 in the centrosome, which in turn induced cell apoptosis. In short, IFIT2 may be a potential target for cancer therapeutics. PMID: 28367102
    2. Mechanistic investigations reveal that AJUBA specifically binds the FERM domain of JAK1 to dissociate JAK1 from the IFNgamma recepter, resulting in an inhibition of STAT1 phosporylation and concomitantly its nuclear translocation. Clinically, the level of AJUBA in CRC specimens is negatively correlated with the levels of IFIT2 and pSTAT1 PMID: 27893714
    3. LINC00161 is an essential regulator in cisplatin-induced apoptosis, and the LINC00161-miR-645-IFIT2 signalling axis plays an important role in reducing osteosarcoma chemoresistance. PMID: 27609068
    4. there is a positive feedback loop between phosphorylated STAT1 and ISG56, ISG54 or ISG60. PMID: 26423178
    5. Data show that interferon-induced proteins with tetratricopeptide repeats 1 and 2 (IFIT1 and IFIT2) contribute to the regulation of hepatitis B virus (HBV) replication, likely at both transcriptional and posttranscriptional steps. PMID: 23867918
    6. Data shows that IFIT2 expression is downregulated in adenocarcinoma of gastric esophageal junction cells; its ectopic expression leads to cell apoptosis, suggesting its role as a tumor suppressor. PMID: 25174799
    7. IFIT2, a protein responsible for interferon stimulation, may prevent oral squamous cell carcinoma (OSCC) metastasis and serve as a valuable prognostic marker. PMID: 22986528
    8. ISG54 binds specifically to some RNAs, such as adenylate uridylate (AU)-rich RNAs, with or without 5' triphosphorylation. PMID: 22825553
    9. Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. PMID: 22065572
    10. The expression of OASL and IFIT2 was significantly higher in SLE patients than in controls. PMID: 20506645
    11. role of ISG54 in the induction of apoptosis via a mitochondrial pathway shedding new light on the mechanism by which IFN elicits anti-viral and anti-cancer effects PMID: 21190939
    12. The expression of interferon-induced genes IFI-54K and IFI-56K in the infected cells was found to increase 50-100-fold PMID: 12708317
    13. We observed that, although double-stranded RNA or Sendai virus infection induced the two genes with similar kinetics, their induction kinetics in response to interferon-beta were quite different. PMID: 16973618
    14. IFN-induced protein with tetratricopeptide repeats 2 inhibits migration activity and increases survival of oral squamous cell carcinoma. PMID: 18819931
    15. IFIT2/GARG39 was identified as a microtubule-associated protein enriched in the mitotic spindle of mouse NIH3T3 and B16F10 melanoma cells. PMID: 17030862

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Endoplasmic reticulum.
  • 蛋白家族:
    IFIT family
  • 數據庫鏈接:

    HGNC: 5409

    OMIM: 147040

    KEGG: hsa:3433

    STRING: 9606.ENSP00000360891

    UniGene: Hs.437609



主站蜘蛛池模板: 香蕉97超级碰碰碰免费公开| 欧美人与禽zoz0性伦交| 国语做受对白xxxxx在线| 欧洲精品一卡2卡三卡4卡影视| 国产新婚夫妇叫床声不断| 亚洲综合国产成人丁香五月激情| 成人性做爰aaa片免费看| 国产女人高潮抽搐叫床视频| 欧美日韩亚洲国产在线制服| 亚洲国产中文在线二区三区免 | 欧美喷潮久久久xxxxx| 国产麻豆成人精品av| 亚洲va在线va天堂xx xx| 亚洲一区二区三区在线网址| 日韩丰满少妇无码内射| 天堂资源中文网| 国产a线视频播放| 国产精品亚洲а∨无码播放麻豆| 亚洲精品国产一区二区精华液| 亚洲另类无码专区国内精品| 热の综合热の国产热の潮在线| 久久久亚洲精品一区二区三区| 亚洲综合无码精品一区二区三区| 国产高潮抽搐喷水高清| 亚洲欧洲无码av一区二区三区| 精品欧美一区二区在线观看| 精品人妻系列无码人妻免费视频 | 亚洲国产精品久久久久久| 一色屋精品视频在线观看免费| 无码潮喷a片无码高潮视频| 香蕉久久福利院| 亚洲va久久久噜噜噜久久男同| 艳妇乳肉豪妇荡乳在线观看| 国产精品综合色区在线观看| 国产精品理论片在线观看| 97久久超碰精品视觉盛宴| 欧美丰满熟妇bbb久久久| 日本一二三区视频在线| 99久久无码一区人妻a片潘金莲 | 国产区在线观看成人精品| 国内女人喷潮完整视频|