在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

ID2 Antibody

  • 中文名稱:
    ID2兔多克隆抗體
  • 貨號:
    CSB-PA448841
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA448841(ID2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA448841(ID2 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    bHLHb26 antibody; Cell growth inhibiting gene 8 antibody; class B basic helix loop helix protein 26 antibody; Class B basic helix-loop-helix protein 26 antibody; DNA binding protein inhibitor ID 2 antibody; DNA binding protein inhibitor ID2 antibody; DNA-binding protein inhibitor ID-2 antibody; GIG 8 antibody; GIG8 antibody; Helix loop helix protein ID2 antibody; ID2 antibody; ID2_HUMAN antibody; ID2A antibody; ID2H antibody; Inhibitor of differentiation 2 antibody; Inhibitor of DNA binding 2 antibody; Inhibitor of DNA binding 2, dominant negative helix loop helix protein antibody; MGC26389 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Fusion protein of Human ID2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Restricts the CLOCK and ARNTL/BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism.
  • 基因功能參考文獻:
    1. Results show that self-assembly decreases the backbone flexibility of ID2 protein regions: helix-loop-helix (HLH) and the nuclear export signal (NES), that are important for interaction with basic-HLH transcription factors or for nucleocytoplasmic shuttling. PMID: 29642431
    2. the results of the present study suggest that lncRNA H19 regulates the expression of ID2 through competitive binding to hsamiR19a and hsamiR19b, which may serve a role in acute myelocytic leukemia cell proliferation. PMID: 28765931
    3. ID2 is localized to peritoneal mesothelial and stromal cells of women with and without endometriosis. ID2 mRNA expression is lower in peritoneum adjacent to the endometriosis lesions compared to distal sites PMID: 27385728
    4. The ID2 gene expression was increased in the most advanced stage of endometriosis and in ovarian endometriomas. Considering that the genes studied participate either directly or indirectly in cellular processes that can lead to cell migration, angiogenesis, and inappropriate invasion, it is possible that the deregulation of these genes caused the development and maintenance of ectopic tissue. PMID: 28678915
    5. Data indicate that the expression level of ID2 in GBM cells can predict the sensitivity of GBM-derived tumor cells to decreased glucose levels. PMID: 28206987
    6. Results show that ID2 signaling was involved in BMP4-induced hepatocellular carcinoma proliferation and that Id2 was directly upregulated by BMP4, resulting in the mediated expression of cell cycle regulatory protein of CDKN1B. PMID: 28543546
    7. EYA4 functions as tumor suppressor gene in pancreatic ductal adenocarcinoma via repressing beta-catenin/ID2 activation, and was an independent prognostic factor in PDAC. PMID: 27378242
    8. Results show that MLL-AF9 reduces Id2 and increases E2-2 expression to drive and sustain leukemia stem cell potential in MLL-rearranged acute myeloid leukemia (AML). Low expression of Id2 or of an Id2 gene signature is associated with poor prognosis in not only MLL-rearranged but also t(8;21) AML patients. PMID: 27374225
    9. We further demonstrated, for the first time, that the degree of hypoxia-induced CSC-sphere formation (CD44(+) subpopulation) in vitro and of tumor metastasis/dissemination in vivo were markedly suppressed by knocking down Id2 expression PMID: 26965643
    10. ID2 knockdown triggers important changes in cell behavior, that is, it significantly reduces the expression of N-cadherin, vimentin and Snail, induces E-cadherin expression and leads to a more differentiated phenotype exemplified by changes in cell shape. ID2 therefore represents a potential therapeutic target during salivary gland cancer progression PMID: 27364596
    11. cell invasion drastically increased with increased expression and activity of MMP2. Immunoprecipitation revealed a direct interaction between ID2 and zinc finger transcription factor, snail family transcriptional repressor 1 (SNAIL1) PMID: 27807072
    12. High Id2 expression is associated with Neuroblatoma. PMID: 25771836
    13. ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Cullin 2, and impairs HIF2alpha ubiquitylation and degradation PMID: 26735018
    14. Downregulation of the Id2 gene by RNAi could increase the chemosensitivity of glioblastoma cells. Id2 could be a good molecular target for glioblastoma gene therapy. PMID: 25773386
    15. role of Id2-TGFbeta crosstalk in reversible adaptive plasticity in neuroblastoma PMID: 24376712
    16. Importantly, the distinct ID2 expression patterns in acute leukemias (AL) indicate a specific deregulation of ID2 in the various types of AL and may support subtyping of AL. PMID: 24292846
    17. ID2 was involved in cancer cell responses to Arsenic Tri-Oxide (ATO). Increased expression of ID2 was found in cancer cells following ATO treatment. In addition, specific silencing of ID2 enhanced cell apoptosis induced by ATO treatment. PMID: 25076250
    18. study shows that Id2, Id3 and Id4 are each able to overcome TGF-beta dependence, and establish a role for Ids as key mediators of TGF-beta melanomagenesis PMID: 24343358
    19. Id2 overexpression in neural stem cells is associated with inhibition of the Notch effector Hey1 and glioma formation in the brains of mice. PMID: 24425046
    20. PreBII large cells in adults, but not in children, showed highly upregulated expression of the differentiation inhibitor, inhibitor of DNA binding 2 (ID2), in absence of changes in expression of the ID2-binding partner E2A. PMID: 23825313
    21. A reduction in Id2 is critical for transforming growth factor (TGF)beta1-induced alpha-SMA expression in renal proximal tubule epithelial cells but is not sufficient in it self to induce alphaSMA (smooth muscle actin) even in the context of reduced E-cadherin. PMID: 23320068
    22. ID2 expression affects the susceptibility hepatoma cell lines to an HDAC inhibitor by regulating the expression of anti-apoptotic genes. PMID: 23403953
    23. Id2 induces squamous cell carcinoma tumor growth and proliferation through the NF-kappaB/cyclin D1 pathway. PMID: 22835384
    24. Higher ID2 expression was associated with advanced breast cancer. PMID: 23645773
    25. upregulated H19 increases bladder cancer growth by regulating ID2 expression PMID: 23399020
    26. Data indicate that ID2.K47A, ID2.Q55A and ID3.R52A, ID3.R60A had wildtype like expression levels in E. coli. PMID: 23119064
    27. preliminary X-ray data analysis of the human ID2 homodimer PMID: 23143248
    28. A critical role of Id2 is revealed in the control of effector CD4 T cell population size and the development of T helper (Th) cell type 17-mediated autoimmune encephalomyelitis. PMID: 22745378
    29. ID2 in nucleus was increased in nasopharyngeal carcinoma when compared with that in normal nasopharynx tissues. Higher expression level of nuclear ID2 was significantly associated with tumor size, lymph node metastasis, and clinical stage. PMID: 22551584
    30. Id2 mutations do not seem to be involved in ureteropelvic junction obstruction. PMID: 21927809
    31. Id2 and Id4 regulated glioblastoma multiforme neurosphere differentiation through downregulating of another bHLH family member, the oligodendroglial lineage-associated transcription factors (Olig) 1 and 2 PMID: 22380883
    32. This review reported that ID2 protein is a negative transcription factor regulating oligodendroglia differentiation. PMID: 22253220
    33. Findings indicate that Id2 functions as a proproliferative gene that antagonizes p53-mediated cell cycle regulation in NPCs and may contribute to the malignant proliferation of glioma-derived tumor stem cells. PMID: 21608079
    34. Large scale RNAi screen reveals that the inhibitor of DNA binding 2 (ID2) protein is repressed by p53 family member p63 and functions in human keratinocyte differentiation. PMID: 21478550
    35. AMP-activated protein kinase (PRKAA1/2, aka AMPK) mediates the stress-induced proteasome-dependent loss of ID2 at high stress levels. PMID: 20876741
    36. expression of vFLIP decreased the expression levels of Id2 and Id3 as well as cyclin E and cyclin A compared with the vFLIP-null cells PMID: 20512523
    37. ID2 can interact with the canonical clock components CLOCK and BMAL1 and mediate inhibitory effects on mPer1 expression PMID: 20861012
    38. T cell development is impaired by Id2, most likely by sequestering HEB, whereas NK cell development is promoted by increasing a pool of CD1a-CD5+ NK cell progenitors, which together with IL-15 differentiate into mature NK cells PMID: 20483740
    39. VEGF165 may partially inhibit TGF-beta1-induced epithelial-mesenchymal transition by upregulating the expressions of BMP-7 and Id2. PMID: 19180920
    40. Metastatic tumor cells overexpress c-myc, leading to upregulation of Id2 expression; the aberrantly elevated amount of Id2 represses SEMA3F expression and, as a consequence, enhances the ability of tumor cells to migrate and invade. PMID: 20388805
    41. Hypoxia-induced ID-2 may contribute to joint destruction in rheumatoid arthritis patients by promoting synovial fibroblast-dependent osteoclastogenesis. PMID: 19950294
    42. Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma. PMID: 11782392
    43. determination as a novel target of transcriptional activation by EWS-ETS fusion proteins in Ewing family tumors PMID: 12447693
    44. upregulation is mediated by the chimeric EWS/ets protein in Ewing sarcoma PMID: 12527902
    45. We found no correlation between MYCN and ID2 expression in neuroblastoma cell lines or tumor specimens. However, we did find a significant positive correlation between MYC and ID2 expressions in both MYCN-amplified and single-copy tumor specimens PMID: 12545167
    46. Id2 is up-regulated during dendritic cells development in vitro and crucial for the development of distinct dendritic cells subsets in vivo PMID: 12598895
    47. Transcriptional regulation of ID2 by the MycN oncoprotein is unlikely to be a seminal molecular event resulting in a highly malignant neuroblastoma phenotype. PMID: 12670915
    48. Mad expression and Id2 down-regulation are important events during the TGF-beta cytostatic program in epithelial cells. PMID: 12824180
    49. The decreased level of Id2 was associated with growth suppression and does support the prevalent conception of the action of Id2 as a stimulator of cell growth PMID: 14582708
    50. ID-2 appears to act as an important protein for the maintenance of a differentiated and noninvasive phenotype in normal and transformed breast cells. PMID: 14612502

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Highly expressed in early fetal tissues, including those of the central nervous system.
  • 數據庫鏈接:

    HGNC: 5361

    OMIM: 600386

    KEGG: hsa:3398

    STRING: 9606.ENSP00000234091

    UniGene: Hs.180919



主站蜘蛛池模板: 巨乳美乳一区二区三区| 少妇的肉体k8经典| 夜夜欢性恔免费视频| 伊人久久大香线蕉综合5g| 国产午夜福利小视频合集| 国产裸体舞一区二区三区 | 性欧美丰满熟妇xxxx性仙踪林| 99久热在线精品视频观看| 羞羞视频在线观看| 国产av区男人的天堂| 日本无码一区二区三区不卡免费| 国产日韩成人内射视频| 精品亚洲一区二区三区在线观看| 中文字幕一区二区人妻电影| 丰满人妻被公侵犯完整版| 国产亚洲精品第一综合麻豆| 亚洲人妻av伦理| 香蕉午夜福利院| 人人做人人爽国产视| 热99re久久国超精品首页| 激情按摩系列片aaaa| 久久这里只精品国产免费10| 亚洲一本大道av久在线播放| 国产成人无码午夜福利在线直播| 骚动漫十八禁在线观看| 久久人妻av一区二区软件| 色欲av无码一区二区人妻| 亚洲电影天堂av2017| 伊人精品无码av一区二区三区| 亚洲中文字幕无码中文字| 女人与拘性猛交视频| 成人亚洲精品久久99狠狠| 色天使久久综合给合久久97色| 欧美浓毛大泬视频| 精品无人区卡一卡二卡三乱码| 中文www天堂| 奇米影视7777久久精品人人爽| 亚洲熟女乱综合一区二区| 大肉大捧一进一出好爽视频动漫 | 日产精品一区2区卡四卡二卡| 丁香婷婷六月综合交清|