在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. Htra1 Antibody

Htra1 Antibody

  • 中文名稱：
    Htra1兔多克隆抗體
  • 貨號：
    CSB-PA879501ZA01MO
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: Htra1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 39 kDa
      Observed band size: 40 kDa
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Serine protease HTRA1 (EC 3.4.21.-) (High-temperature requirement A serine peptidase 1) (Serine protease 11), Htra1, Htra Prss11
  • 反應(yīng)種屬：
    Salmonella enterica (Salmonella choleraesuis)
  • 免疫原：
    Recombinant Mouse Serine protease HTRA1 (Htra1), partial (141-480AA)
  • 免疫原種屬：
    Mus musculus (Mouse)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Protein G
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves or not. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
  • 基因功能參考文獻：
    1. transfection of cells with a constitutively active rapamycin-resistant p70S6K mutant could restore the mineralizing capacity of HtrA1-deficient mouse adipose-derived stromal cells. PMID: 26950191
    2. HtrA1 plays important roles in the differentiation of trophoblasts from Tpbpa-positive precursors in the ectoplacental cone PMID: 25446274
    3. The HtrA1 overexpression and mainstream cigarette smoke can independently lead to CNV. The HtrA1 gene is a strong risk factor for wet AMD PMID: 25205867
    4. the inhibitory effect of IFN-gamma on HTRA1 expression was evidenced in collagen-induced arthritis (CIA) mouse models and in human RA synovial cells. PMID: 24907345
    5. Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PMID: 24040176
    6. This study offers new insights into the regulation of HTRA-1 expression via LPS/TLR-4 and the role of HTRA-1 in rheumatoid arthrisis pathogenesis. PMID: 23982886
    7. suggest a critical role for LRP1 in maintaining the integrity of vessels by regulating protease activity as well as matrix deposition by modulating HtrA1 and connective tissue growth factor protein levels. PMID: 23868935
    8. a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD. PMID: 22049084
    9. showed that increased HTRA1 induced cardinal features of polypoidal choroidal vasculopathy, including branching networks of choroidal vessels, polypoidal lesions, severe degeneration of the elastic laminae, and tunica media of choroidal vessels PMID: 21844367
    10. HtrA1 may disrupt the pericellular matrix network, resulting in alteration of chondrocyte metabolisms. This eventually leads to osteoarthritis. PMID: 20238298
    11. HtrA1 has a role in promoting anoikis by attenuating activation of EGFR/AKT pathway that may contribute to its metastasis suppression capacity PMID: 20388781
    12. During embryo development, HtrA1 was expressed in specific areas where signaling by Tgfbeta family proteins plays important regulatory roles PMID: 14973287
    13. HtrA1 as a protease potentially important for trophoblast differentiation/invasion and uterine decidual regression during placental development PMID: 15861393
    14. bone matrix shows a high level of HtrA1 protein deposition akin to that of TGF-beta, suggesting a close functional interaction between TGF-beta and HtrA1 PMID: 15993670
    15. highly upregulated during mucosal mast cell differentiation PMID: 17292962
    16. HtrA1 and PRSS35 may be involved in ovulation and corpus luteum formation and regression, and that PRSS23 may play a role in follicular atresia PMID: 18566130

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane. Secreted. Cytoplasm, cytosol.
  • 蛋白家族：
    Peptidase S1C family
  • 組織特異性：
    In the brain, mainly expressed in cortical areas both in glial cells and neurons (at protein level). In bones, deposited in the matrix, with higher level in newly formed bone compared to fully calcified bone (at protein level). Also expressed in the tendo
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 强行交换配乱婬bd| 日本午夜看x费免| 国产精品自在自线视频| 亚洲中文字幕乱码一区| 亚洲国产aⅴ综合网| 日本熟妇乱人伦a片免费高清 | 欧美激情a∨在线视频播放| 免费大黄网站在线观| 日韩丝袜欧美人妻制服| 日日摸天天摸人人看| 日本特黄aaaaaa大片| 亚洲国产精品第一区二区| 亚欧美无遮挡hd高清在线视频| 丁香五月激情综合色婷婷| 中国精品无码免费专区午夜| 亚洲欧美成人中文日韩电影网站| gv天堂gv无码男同在线观看| 久久久久久九九99精品| 国产女人高潮视频在线观看| 国产欧美va天堂在线电影| 成人免费大片黄在线观看com| 欧美日韩一区二区三区在线观看视频| 一本一本久久a久久精品综合| 亚洲一卡2卡3卡4卡 精品| 午夜爱爱免费视频体验区| 亚洲第一狼人伊人av| 2022国产成人精品视频人| 国产精品欧美一区二区三区| 少妇仑乱a毛片无码| 国产未成女一区二区| 精品卡一卡二卡3卡高清乱码| 欧美成人看片黄a免费看| 色妞精品av一区二区三区| 日韩精品无码人成视频| 国产成人a人亚洲精v品无码| 人妻无码久久精品| 丰满人妻被公侵犯高清版| 巨熟乳波霸若妻在线播放| 欧美色欧美亚洲高清在线视频| 国产大屁股喷水视频在线观看| 国产成人午夜福利在线播放|