在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HTR7 Antibody

  • 中文名稱:
    HTR7兔多克隆抗體
  • 貨號:
    CSB-PA010899LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA010899LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) HTR7 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    HTR7; 5-hydroxytryptamine receptor 7; 5-HT-7; 5-HT7; 5-HT-X; Serotonin receptor 7
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human 5-hydroxytryptamine receptor 7 protein (1-83AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,HTR7 Antibody (CSB-PA010899LA01HU),的標記方式是Non-conjugated。對于HTR7 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA010899LB01HU HTR7 Antibody, HRP conjugated ELISA
    FITC CSB-PA010899LC01HU HTR7 Antibody, FITC conjugated
    Biotin CSB-PA010899LD01HU HTR7 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
  • 基因功能參考文獻:
    1. Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Galphas upon receptor activation. PMID: 29079700
    2. The dizygotic twins presented here carry a compound heterozygous variant in the HTR7 gene. No other coding sequence abnormalities (CNVs and SVs) were observed in their fully sequenced genomes consistent with either dominant or recessive inheritance. This provides a first suggestive genetic link between the 5-HT7 receptor and autism spectrum disorder in patients. PMID: 27380831
    3. Placental expression of HTR7 was significantly increased in women with pre-eclampsia compared to controls. PMID: 26797415
    4. PTP1B directly regulates STAT5 phosphorylation and its activation via the cAMP/PKA pathway downstream of the 5-HT7 receptor is involved in the suppression of beta-casein expression in MCF-12A cells PMID: 27016479
    5. Study shows that HTR7 variants are not related to the overall improvement in schizophrenia symptoms following perospirone or aripiprazole treatment PMID: 26609891
    6. Study demonstrated that binding of clozapine or olanzapine to the 5-HT7 receptor leads to antagonist-mediated lysosomal degradation by exposing key residues in the C-terminal tail that interact with GASP-1 PMID: 25706089
    7. This is a review of literature about how 5-HT7 receptor has been implicated in cognitive disturbances, sleep and circadian rhythmicity disorders, anxiety and depression PMID: 25228519
    8. Genetic variations in HTR7 serotonin receptor contribute to the predisposition for alcohol dependence. PMID: 25070732
    9. There is a cross-reactivity between 5-HT7 and 5-HT1A receptors and in this review they are shown to have a role in depressive disorders. PMID: 24935787
    10. the expression of 5-HT7 receptors in brain tissues was higher in the epilepsy group compared with the nonepileptic group; the results suggested that 5-HT7 receptors participate in the pathogenesis of temporal lobe epilepsy PMID: 22543085
    11. The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor. PMID: 22245496
    12. The role of the 5-HT7 receptor in the central nervous system, is discussed. PMID: 21424680
    13. The association with rs7916403 in serotonin receptor gene HTR7 on chromosome 10q23 (combined P = 1.53 x 10), implicates the serotonergic system in the neurophysiological underpinnings of theta event-related brain oscillations. PMID: 21184583
    14. Ability of non-inactivating drugs to bind h5-HT(7) orthosteric sites and reverse wash-resistant effects of risperidone/9-OH-risperidone, also bound to h5-HT(7) orthosteric sites, is evidence for protomer-protomer interactions between h5-HT(7) homodimers. PMID: 20827463
    15. HEK293 cells stably or transiently expressing either of the 5-HT7 receptor splice variants show elevated basal adenylyl cyclase (AC) activity as well as concentration-dependent inhibition of basal AC activity by 5-HT7 antagonists (inverse agonism). PMID: 11906971
    16. The decrease in affinity of 5-HT and other 5-HT receptor agonists at the (Thr92Lys) h5-HT7 receptor may be associated with changes of sleep physiology and of actions of new 5-HT7 receptor agonists designed to treat circadian dysregulation. PMID: 15896881
    17. HTR7 is a susceptibility gene for schizophrenia in this Japanese group. PMID: 16192982
    18. This may indicate that the h5-HT7 receptor is part of a subfamily of G-protein-coupled receptors (GPCRs) possessing this property or that many GPCRs have the potential to be irreversibly blocked, but only select drugs can induce this effect. PMID: 16870886
    19. These observations suggest that PLAC-24 may play a role in the transport and the stabilisation of newly synthesised 5-HT(7) receptor towards the plasma membrane. PMID: 16935469
    20. Results support the essential role of Sp factors in regulating 5-HT(7) promoter activity. PMID: 17321075
    21. data demonstrate a role for sphingomyelin and gangliosides in regulating binding of [(3)H]5-HT to 5-HT(7) receptors; these observations further strengthen that actions of 5-HT via 5-HT(7) receptors are dependent upon lipid raft integrity PMID: 17428232
    22. Caveolin-1, specifically localized in cholesterol-enriched lipid rafts, appears to regulate constitutive and agonist-stimulated cell surface levels of 5-HT7 receptors via a clathrin-independent mechanism. PMID: 17936759
    23. Data show that 5-HT(7) receptors are involved in the modulation of learning and memory processes. PMID: 18243350
    24. The results of this study demonstrate that variations in the HTR7 gene may not be good genetic markers for predicting the therapeutic efficacy of risperidone. PMID: 19233240

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Isoform A is the predominant isoform in spleen, caudate and hippocampus. Isoform B is expressed at lower levels. Isoform D is a minor isoform in terms of expression.
  • 數據庫鏈接:

    HGNC: 5302

    OMIM: 182137

    KEGG: hsa:3363

    STRING: 9606.ENSP00000337949

    UniGene: Hs.73739



主站蜘蛛池模板: 国产欧美成人xxx视频| 精品少妇人妻av免费久久洗澡| 一二三四在线视频社区3| 波多野结衣av无码| 国内大量揄拍人妻精品視頻| 一区二区久久久久草草| 亚洲成αv人片在线观看| 粉嫩大学生无套内射无码卡视频| 后入内射无码人妻一区| 欧美老肥妇做爰bbww | 国产精品久久久天天影视| 欧美黑人异族videos| 欧美日韩一本无线码专区| 国产亚洲精品a片久久久| 野花社区视频在线观看| 亚洲啪啪综合av一区| 青青青国产免a在线观看| 久久无码高潮喷水抽搐| 欧美精品人人做人人爱视频| 蜜臀av夜夜澡人人爽人人| 亚洲欧美日韩成人一区| 中文字幕av久久激情亚洲精品| 开心色怡人综合网站| 亚洲 a v无 码免 费 成 人 a v| 99久久精品日本一区二区免费| 中文字幕久久久久人妻中出| 亚洲成av 人片在线观看无码| 欧美疯狂xxxxbbbb喷潮| 巨爆乳中文字幕爆乳区| 18禁成年免费无码国产| 亚洲精品乱码一区二区三区| 2020国产精品午夜福利在线观看 | 国产成人久久精品二区三区| 精品三级av无码一区| 久久久久 亚洲 无码 av 专区| 欧美人与动牲交zooz| 成人爽a毛片免费啪啪| 国产二级一片内射视频播放| 无码免费无线观看在线视| 亚洲欧洲日韩综合久久| 中文天堂国产最新|