在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSPH1 Antibody

  • 中文名稱:
    HSPH1兔多克隆抗體
  • 貨號:
    CSB-PA010869GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Antigen NY CO 25 antibody; Antigen NY-CO-25 antibody; DKFZp686M05240 antibody; Heat shock 105kD alpha antibody; Heat shock 105kD antibody; Heat shock 105kD beta antibody; Heat shock 105kDa protein 1 antibody; Heat shock 105kDa protein antibody; Heat shock 105kDa/110kDa protein 1 antibody; Heat shock 110 kDa protein antibody; Heat shock 110kDa protein antibody; Heat shock protein 105 kDa antibody; HS105_HUMAN antibody; HSP105 antibody; HSP105A antibody; HSP105B antibody; HSP110 antibody; HSPH 1 antibody; Hsph1 antibody; KIAA0201 antibody; NY CO 25 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HSPH1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release. Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities.
  • 基因功能參考文獻:
    1. expression not an independent prognostic factor in gastric cancer patients with peritoneal metastasis, but might be a new marker of chemosensitivity PMID: 29204054
    2. Established heat shock protein 110 (HSP110) as a prognostic biomarker of colorectal carcinomas (CRCs) with microsatellite instability-high (MSI-H) by considering the intratumoral heterogeneity of HSP110 expression. The HSP110wt-low MSI-H CRCs were significantly correlated with larger deletions in the HSP110 T17 mononucleotide repeat (>/=4 bp; p < 0.001). PMID: 28971530
    3. HSP110 HT17 alone correctly classified samples judged to be uncertain with the pentaplex panel. PMID: 26831756
    4. deletion of the HSP110 T17 repeat was frequently observed in microsatellite-unstable advanced gastric cancers. PMID: 28811251
    5. Hsp105alpha localizes to the nucleus, interacts with HIF-1alpha and induces HIF-1a accumulation in CoCl2-treated cells. PMID: 28185835
    6. the expression of HSP110 in colon cancer contributes to STAT3-dependent tumor growth PMID: 27819670
    7. About 25% of patients with stages II-III colorectal tumors with microsatellite instability have an excellent response to chemotherapy, due to large, biallelic deletions in the T(17) intron repeat of HSP110 in tumor DNA. PMID: 24512910
    8. HSP105 depletion disrupts the integration of protein phosphatase 2A into the beta-catenin degradation complex, favoring the hyperphosphorylation and degradation of beta-catenin. PMID: 25645927
    9. A receiver operating characteristic curve constructed with HSP105 and TIM gave a sensitivity of 54.3% and 95% (38/40) specificity in discriminating esophageal squamous cell carcinoma from matched controls. PMID: 24157810
    10. we measured the binding of human Hsp72 (HSPA1A) to BAG1, BAG2, BAG3, and the unrelated NEF Hsp105. These studies revealed a clear hierarchy of affinities: BAG3 > BAG1 > Hsp105 >> BAG2. PMID: 24318877
    11. HSPH1 and HSPH2 are bona fide chaperones on their own that collaborate with DNAJA1 and DNAJB1 to hydrolyze ATP and unfold polypeptides and HSPA1A and HSPH1 formed a powerful molecular machinery. PMID: 23737532
    12. High HSP105 expression is associated with Barrett's esophagus. PMID: 22901192
    13. It restricts aggregation of denaturated proteins,plays a role in protein folding in cytoplasms,and enhance expression of hsp70 in cell nucleus.(review) PMID: 22712230
    14. The Hsp105-mediated multilevel regulation of DeltaF508 CFTR folding and quality control provides new opportunities to understand how chaperone machinery regulates the homeostasis and functional expression of misfolded proteins in the cell. PMID: 22505710
    15. A direct correlation between HSP105 expression and lymphoma aggressiveness was also apparent. PMID: 21860023
    16. Hsp105alpha and Hsp105beta suppressed the expanded polyQ tract-induced protein aggregation and apoptosis through the induction of Hsp70. PMID: 20542028
    17. Heat shock protein 105 is overexpressed in a variety of human tumors PMID: 14534695
    18. HSP105 appears to chaperone the responses to endoplasmic reticulum (ER) stress through its interactions with GRP78 and GSK3, and without HSP105 cell death following ER stress proceeds by a non-caspase-3-dependent process. PMID: 18083346
    19. HSP105 analysis may be a helpful tool as a poor prognostic indicator and as a diagnostic aid in problematic lesions. PMID: 18477890
    20. HSP 105 is thought to be a more relevant tumor-associated antigen in malignant melanoma than is HSP 70. PMID: 19476517

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Heat shock protein 70 family
  • 組織特異性:
    Highly expressed in testis. Present at lower levels in most brain regions, except cerebellum. Overexpressed in cancer cells.
  • 數據庫鏈接:

    HGNC: 16969

    OMIM: 610703

    KEGG: hsa:10808

    STRING: 9606.ENSP00000318687

    UniGene: Hs.743267



主站蜘蛛池模板: 男女啪啪激烈高潮喷出gif免费| 国产亚洲日韩在线三区| 国产欲女高潮正在播放| 中文字幕av久久激情亚洲精品 | 亚洲制服有码在线丝袜| 国产精品亚洲片在线观看不卡 | 久久久中文久久久无码| 东京热人妻无码一区二区av | 熟妇人妻av中文字幕老熟妇| 亚洲性啪啪无码av天堂| 99精品国产在热久久婷婷| 国产精品青青在线观看爽香蕉| 国产av国内精品jk制服| 天天做天天欢摸夜夜摸狠狠摸| 国产av影片麻豆精品传媒| 韩国和日本免费不卡在线v| 国产欧美成人一区二区a片| 无码日韩人妻精品久久蜜桃| 级毛片内射视频| 曰韩欧美群交p片内射| 国产成人亚洲综合图区| 色老99久久精品偷偷鲁| 伊人久久大香线蕉综合75| 大又大粗又爽又黄少妇毛片| 亚洲国产精品成人一区二区在线| 超碰国产精品人人做人人爱| 国产精品丝袜亚洲熟女| 国产激情电影综合在线看| 新香蕉少妇视频网站| 精品香蕉99久久久久网站| 人妻体内射精一区二区三区| 国产婷婷成人久久av免费高清| 在线aⅴ亚洲中文字幕| 久久人人爽人人爽爽久久小说 | 国产精品久久久久久久久绿色| 国产成人精品一区二区在线小狼| 欧美多人片高潮野外做片黑人 | 人妻少妇乱孑伦无码专区蜜柚| 日本无码一区二区三区不卡免费| 粉嫩小泬无遮挡久久久久久| 中国亚洲女人69内射少妇|