在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSPB6 Antibody

  • 中文名稱:
    HSPB6兔多克隆抗體
  • 貨號:
    CSB-PA085605
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA085605(HSPB6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA085605(HSPB6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    HSPB6
  • 別名:
    epididymis luminal protein 55 antibody; FLJ32389 antibody; Heat shock 20 kDa like protein p20 antibody; Heat shock 20 kDa-like protein p20 antibody; Heat shock protein alpha crystallin related B6 antibody; Heat shock protein beta 6 antibody; Heat shock protein beta-6 antibody; Heat shock protein; 20-KD antibody; Heat-shock 27-KD protein 6 antibody; HEL55 antibody; Hsp20 antibody; HspB6 antibody; HSPB6_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human HSPB6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Seems to have versatile functions in various biological processes. Plays a role in regulating muscle function such as smooth muscle vasorelaxation and cardiac myocyte contractility. May regulate myocardial angiogenesis implicating KDR. Overexpression mediates cardioprotection and angiogenesis after induced damage. Stabilizes monomeric YWHAZ thereby supporting YWHAZ chaperone-like activity.
  • 基因功能參考文獻:
    1. Structural basis for the interaction of a human HSPB6 protein with the 14-3-3 universal signaling regulator has been reported. PMID: 28089448
    2. Data suggest that HSPB6 forms hetero-oligomers with HSPB1 under the following rules: (1) highly conserved motif RLFDQXFG is necessary for subunit exchange among oligomers, (2) a site about 20 residues downstream of this motif determines size of resultant hetero-oligomers, and (3) a region in the N-terminal domain that is unique to HSPB6 dictates preferential formation of heterodimers. (HSP = heat shock protein) PMID: 28487364
    3. findings strongly suggest that phosphorylated HSP20 inhibits TGF-alpha-induced HCC cell migration and invasion via suppression of the JNK signaling pathway PMID: 27046040
    4. multiple sclerosis lesions revealed exclusive induction of HSPB6 in astrocytes, as confirmed by co-localization of HSPB6 with GFAP. PMID: 26694816
    5. N-terminal mutations increase stability of large HspB1 homooligomers, prevent their phosphorylation-dependent dissociation, modulate their interaction with HspB6 and decrease their chaperoning capacity, preventing normal functioning of HspB1. PMID: 25965061
    6. Findings strongly suggest that HSP20 directly associates with Bax and stimulates caspase cascade in human hepatocellular carcinoma cells. PMID: 24969689
    7. Data suggest that heat shock protein 20 (HSP20) may have value as a prognostic tumor marker and its overexpression might be a novel strategy for colorectal cancer (CRC) therapy. PMID: 25187324
    8. peptides in heat-shock protein Hsp20 (G71HFSVLLDVKHFSPEEIAVK91) and Hsp27 (D93RWRVSLDVNHFAPDELTVK113) with sequence homology to alpha-crystallin also have robust chaperone and anti-apoptotic activities. PMID: 25332102
    9. These findings strongly suggest that HSP20 might decrease the IKK-alpha protein level and that it down-regulates the TNF-alpha-stimulated intracellular signaling in HCC, thus resulting in the suppression of HCC progression. PMID: 25447820
    10. HSP20 may play a protective role against the progression of ovarian cancer. PMID: 25423708
    11. HSP20 directly associates with PI3K subunits and suppresses its activity in hepatocellular carcinoma, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of hepatocellular carcinoma. PMID: 24223153
    12. 14-3-3zeta and possibly other 14-3-3 isoforms may have additional functional roles conducted by the monomeric state PMID: 22794279
    13. the cytosolic protein AKAP-Lbc (AKAP13) as the anchoring protein responsible for directing PKA phosphorylation of Hsp20 on Ser(16) PMID: 22731613
    14. Hsp20 serves as a novel cardiokine in regulating myocardial angiogenesis through activation of the VEGFR signaling cascade. PMID: 22427880
    15. cofilins 1 and 2 only weakly interact with 14-3-3 and therefore cannot directly compete with phosphorylated small heat shock protein HspB6 for its binding to 14-3-3 PMID: 22450169
    16. Properties of the monomeric form of 14-3-3zeta protein and its interaction with tau and HspB6. This interaction requires phosphorylation of tau protein and HspB6. PMID: 21978388
    17. A potential molecular mechanism by which Hsp20 acetylation can affect myometrial activity by liberating cofilin PMID: 21803775
    18. Overexpression of HSPB1, as well as HSPB6, HSPB7 and HSPB8 independently protect against tachycardia remodeling by attenuation of the RhoA GTPase pathway at different levels. PMID: 21731611
    19. Nevertheless, in solution, both alpha-crystallin domain proteins form stable dimers via the symmetric antiparallel interaction of beta7 strands. PMID: 21641913
    20. The 14-3-3 zeta mutation mimicking phosphorylation of Ser184 does not markedly affect interaction with tau protein and improves the interaction of 14-3-3 zeta with HspB6. PMID: 21081103
    21. Data show that the interaction between HspB6 and Bag3 requires the same regions that are involved in the HspB8-Bag3 association. PMID: 19845507
    22. Our results suggest that a variety of oligomers composed of different proportions of different sHSPs may form in cell types expressing multiple sHSPs. PMID: 16225851
    23. Phosphorylation led to changes in actin cytoskeletal morphology in 3T3 cells, delineating strategies for the expression and activation of therapeutic molecules for intracellular protein based therapeutics. PMID: 17084643
    24. Interaction of human 14-3-3gamma with the small heat shock protein Hsp20 was analyzed by means of size-exclusion chromatography and chemical crosslinking. PMID: 17109079
    25. Data support a novel role for pHSP20 in the modulation of cyclic-nucleotide-mediated myometrial relaxation, through interaction with actin. pHSP20 represents an important new target for future tocolytic therapy. PMID: 18755793
    26. AZX100, an analogue of the small heat shock protein, HSP20, reduces TGF-beta1-induced CTGF expression in keloid fibroblasts PMID: 18787533
    27. Human mutation in the anti-apoptotic heat shock protein 20 abrogates its cardioprotective effects PMID: 18790732
    28. Here, crystal structures of excised alpha-crystallin domain from rat Hsp20 and that from human alphaB-crystallin show that they form homodimers with a shared groove at the interface by extending a beta sheet. PMID: 19646995
    29. Report increased levels of phosphorylated Hsp20 in failing hearts. PMID: 19850943

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Secreted.
  • 蛋白家族:
    Small heat shock protein (HSP20) family
  • 數據庫鏈接:

    HGNC: 26511

    OMIM: 610695

    KEGG: hsa:126393

    STRING: 9606.ENSP00000004982

    UniGene: Hs.534538



主站蜘蛛池模板: 插一插射一射视频| 在线精品国精品国产尤物| 一区二区三区四区在线不卡高清| 特黄做受又粗又大又硬老头| 凹凸国产熟女精品视频app| 中文字幕精品久久久久人妻红杏ⅰ| 成年免费视频黄网站在线观看| 国产精品久久久久久无码五月| 成人爽a毛片在线视频淮北| 国产日产欧产精品品不卡| 女人下边被添全过视频| 精品国产免费一区二区三区 | 免费又黄又爽1000禁片 | 国产午夜无码片在线观看| 久久久久99精品成人片试看 | 亚洲人亚洲人成电影网站色| 国产成人精品日本亚洲第一区 | 国产乱来乱子视频| 777精品出轨人妻国产| 在线精品国精品国产尤物| 国产免费午夜a无码v视频| 亚洲区日韩精品中文字幕| 337人体做爰大胆视频| 尤物色综合欧美五月俺也去| 九九综合va免费看| 特级毛片爽www免费版| 国产亚洲精品久久久久动漫| 一边做一边喷17p亚洲乱妇50p| 四虎www成人影院观看| 精品国产一区二区三区av性色| 日本丰满妇人成熟免费中文字幕| 成人国产一区二区三区精品不卡| 欧美午夜精品一区二区蜜桃 | 久久婷婷久久一区二区三区| 国产综合视频一区二区三区| 欧美亚洲国产片在线播放| 欧美一进一出抽搐大尺度视频| 久久婷婷色香五月综合缴缴情| www一区二区乱码www| 国产亚州精品女人久久久久久| 欧美性大战久久久久久久|