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HSPA9 Antibody, HRP conjugated

  • 中文名稱:
    HSPA9兔多克隆抗體, HRP偶聯(lián)
  • 貨號:
    CSB-PA010830HB01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) HSPA9 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    75 kDa glucose regulated protein antibody; 75 kDa glucose-regulated protein antibody; CSA antibody; Glucose Regulated Protein antibody; Grp 75 antibody; GRP-75 antibody; GRP75 antibody; GRP75_HUMAN antibody; Heat shock 70 kDa protein 9 antibody; Heat shock 70kD protein 9 antibody; heat shock 70kDa protein 9 antibody; Heat shock 70kDa protein 9B antibody; Heat shock protein 74 kDa A antibody; Heat shock protein A antibody; Heat shock protein cognate 74 antibody; Hsc74 antibody; Hsp74 antibody; Hsp74a antibody; HSPA9 antibody; Hspa9a antibody; HSPA9B antibody; MGC4500 antibody; mitochondrial antibody; Mortalin 2 antibody; Mortalin antibody; Mortalin perinuclear antibody; Mortalin2 antibody; MOT 2 antibody; MOT antibody; MOT2 antibody; Mthsp70 antibody; p66 mortalin antibody; P66 MOT antibody; PBP74 antibody; Peptide binding protein 74 antibody; Peptide-binding protein 74 antibody; Stress 70 protein mitochondrial antibody; Stress 70 protein mitochondrial precursor antibody; Stress-70 protein antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Stress-70 protein, mitochondrial protein (458-679AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging.
  • 基因功能參考文獻(xiàn):
    1. Nfu is shown to bind to both chaperone proteins with binding affinities similar to those observed for IscU binding to the homologous HSPA9 and Hsc20, while Nfu can also stimulate the ATPase activity of HSPA9 PMID: 29211945
    2. this data demonstrates that cells can sense complement activation at the plasma membrane and in response, swiftly send GRP-75 to this region in order to deactivate it PMID: 27475989
    3. role of HAPA9 and its interaction with other mitochondria-related genes are not genetic risk factors for PD or AD. PMID: 28340952
    4. mortalin (HSPA9) directly interacts with PP1alpha and MEK1/2 and facilitates PP1alpha-mediated dephosphorylation of MEK1/2 by promoting their physical interaction, which is important in determining cellular steady-state levels of phosphorylated MEK1/2 and, subsequently, MEK/ERK activity. PMID: 28674184
    5. Identify Mortalin as a significant independent prognostic factor, in addition to location, clinical stage, and perineural invasion, for survival of pancreatic ductal adenocarcinoma patients. PMID: 28412209
    6. these findings indicate that reduced levels of HSPA9 may contribute to TP53 activation and increased apoptosis observed in del(5q)-associated MDS. PMID: 28178280
    7. mortalin is an oncogenic factor. PMID: 27374312
    8. endocytosis vesicle enrichment of GRP75 by mitochondria trafficking upregulates clathrin-independent endocytosis through an actin cytoskeleton reorganization mechanism mediated by the concurrent activation of Cdc42 and RhoA. PMID: 27090015
    9. Mortalin is up-regulated in non-small cell lung cancer, and it may be a potential biomarker of prognostic evaluation and a molecular therapeutic target for patients with early stage of non-small cell lung cancer PMID: 28349826
    10. the mitochondrial stress chaperone mortalin is crucial for melanogenesis. the hyperpigmented keloid skin possesses significantly higher level of mortalin expression. mortalin is increased during oxidative stress and drug-induced melanogenesis. overexpression of mortalin causes an increase in pigmentation and its compromise leads to reduction in melanin content. PMID: 27056733
    11. These findings suggest a regulatory role of human miRNA pathway especially GRP75 protein and hsa-mir-126 in dengue virus replication. PMID: 27039024
    12. UBXN2A binds to mortalin's binding pocket within the substrate-binding domain of mortalin. UBXN2A increases stability of p53 protein targeted by the mortalin-CHIP E3 ubiquitin ligase. PMID: 26634371
    13. Thus Hspa9 regulates erythroid differentiation through ISC cluster assembly, providing a pathophysiological mechanism for an MDS subtype characterized by HSPA9 haploinsufficiency PMID: 26702583
    14. Study shows that Mortalin is upregulated in breast cancer, and may be a useful poor prognostic biomarker for patients with breast cancer. PMID: 26955804
    15. This study showed that human post-mortem tissue indicated co-localization of mortalin within astrocytes. PMID: 26095919
    16. Biallelic mutations in HSPA9 are associated with the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia. PMID: 26598328
    17. veratridine enhances transactivation of UBXN2A, resulting in upregulation of UBXN2A in the cytoplasm, where UBXN2A binds and inhibits the oncoprotein mortalin-2 PMID: 26188124
    18. Impaired stoichiometry between mtHsp40 and mtHsp70 promotes Opa1L cleavage, leading to cristae opening, decreased OXPHOS, and triggering of mitochondrial fragmentation after reduction in their chaperone function. PMID: 25904328
    19. mutations in HSPA9 result in congenital sideroblastic anemia inherited as an autosomal recessive trait PMID: 26491070
    20. Expression of mortalin decreased significantly in dopaminergic cells overexpressing A53T alpha-syn PMID: 25665531
    21. Results present the functional structure of human mortalin showing at least two domains and interacts with adenosine nucleotides with high affinity depending on the presence of Mg2+ ions. PMID: 25615450
    22. Mortalin is a key regulator of multiple signaling and metabolic pathways pivotal to medullary thyroid carcinoma cell survival and proliferation. PMID: 25435367
    23. Human mot-1, R126W, or P509S mutants lack mot-2 functions involved in carcinogenesis. PMID: 25645922
    24. The functional interaction of mortalin with Parkin and PINK1, was investigated. PMID: 24743735
    25. Data indicate that nuclear mortalin (mot-N) efficiently protects cancer cells against endogenous and exogenous oxidative stress. PMID: 25012652
    26. Mortalin-positive tumors were deeper in invasion and had more lymph node and liver metastases in gastric cancer with normal p53 function. PMID: 23828548
    27. Data indicate that complement C9 binds to the ATPase domain of mortalin. PMID: 24719326
    28. UBXN2A binds to mot-2 and releases sequestrated p53, which leads to p53- dependent apoptosis in colon cancer cells with high mot-2. PMID: 24625977
    29. CRP40 is genetically dysregulated in Parkinson disease and presents a significant opportunity for further investigation of molecular chaperone proteins as biomarkers. PMID: 23520075
    30. Bcl-2 and Bcl-xL interact with mortalin and activate p53 function leading to an induction of senescence in cancer cells. PMID: 24050266
    31. Our findings demonstrated that the overexpression of Mortalin is correlated with the metastatic phenotype of HCC cells and can promote EMT, but cannot induce angiogenesis in HCC. PMID: 24190572
    32. Mortalin mediates a switch in tumor-suppressive signaling of Raf/MEK/extracellular signal-regulated kinase. PMID: 23959801
    33. Intracellular localization of apoptin is tightly associated with HSPA9 expression and its crucial role in cellular apoptosis. PMID: 23589050
    34. The results indicate that hHep1 shares some structural similarities with the yeast ortholog despite the low identity and functional differences. PMID: 23462535
    35. elevated levels of mortalin expression increase cancer cell resistance to cisplatin-induced cytotoxicity PMID: 23665506
    36. mortalin and cytosolic HSP70 may have roles in colorectal cancer PMID: 23319326
    37. These results suggest a possible functional role of CRP40 in the pathogenesis of schizophrenia. PMID: 23182727
    38. HSPA9 secreted by oral squamous cell carcinoma cells interacts with podoplanin (PDPN) on their cell surface in an autocrine manner and regulates their growth and invasiveness PMID: 23541579
    39. these data reveal the characteristic cytoplasmic sequestration of p53 by the heat shock protein mortalin in human colorectal adenocarcinoma cell lines, as is the case for other cancers, such as glioblastomas and hepatocellular carcinomas. PMID: 22683628
    40. DNLZ/HEP zinc-binding subdomain is critical for regulation of the mitochondrial chaperone HSPA9. PMID: 22162012
    41. Cytoprotective efficacy of mortalin under Abeta-induced stress in SH-SY5Y cells is mediated, at least in part, by inhibition of mPTP opening. PMID: 22001761
    42. Nef's interaction with cellular mortalin is required for Nef secretion. PMID: 22013042
    43. The present study further demonstrated that GRP75 translocates into the nucleus and physically interacts with retinoid receptors (RARalpha and RXRalpha) to augment retinoic acid-elicited neuronal differentiation. PMID: 22022577
    44. Mortalin is up-regulated in liver tumors. PMID: 21714113
    45. Cisplatin resistance of lung cancer cells is associated with overexpression of GRP75 gene PMID: 21496427
    46. the relatively decreased mortalin expression level and its impaired interaction with Parkin could affect its roles in mitochondrial function. PMID: 21640711
    47. Targeting mortalin-p53 interaction with either mortalin small hairpin RNA or a chemical or peptide inhibitor could induce p53-mediated tumor cell-specific apoptosis in hepatocellular carcinoma; p53-null hepatoma or normal hepatocytes remain unaffected. PMID: 21233847
    48. These findings implicate a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity. PMID: 21530495
    49. Data show that mortalin can afford protection against Abeta(1-42)-induced neurotoxicity in SH-SY5Y cells. PMID: 20974113
    50. the activating mechanism of mitochondrial outer membrane-bound m-calpain and the release of mitochondrial m-calpain PMID: 21145877

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  • 相關(guān)疾?。?/div>
    Anemia, sideroblastic, 4 (SIDBA4); Even-plus syndrome (EVPLS)
  • 亞細(xì)胞定位:
    Mitochondrion. Nucleus, nucleolus.
  • 蛋白家族:
    Heat shock protein 70 family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5244

    OMIM: 182170

    KEGG: hsa:3313

    STRING: 9606.ENSP00000297185

    UniGene: Hs.184233



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