在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. HSPA1L Antibody

HSPA1L Antibody

  • 中文名稱：
    HSPA1L兔多克隆抗體
  • 貨號：
    CSB-PA010823GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Heat shock 70 kDa protein 1 Hom antibody; Heat shock 70 kDa protein 1 like antibody; Heat shock 70 kDa protein 1-Hom antibody; Heat shock 70 kDa protein 1-like antibody; Heat shock 70 kDa protein 1L antibody; Heat shock 70kD protein like 1 antibody; HS71L_HUMAN antibody; HSP70 1L antibody; HSP70 HOM antibody; HSP70-Hom antibody; HSPA1L antibody; hum70t antibody; Spermatid specific heat shock protein 70 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human HSPA1L
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
  • 基因功能參考文獻：
    1. HSP70-HOM gene polymorphism associated with susceptibility to noise-induced hearing loss. PMID: 29072670
    2. In a cohort of youth at risk for bipolar disorder, pathway analysis showed an enrichment of the glucocorticoid receptor (GR) pathway with the genes MED1, HSPA1L, GTF2A1 and TAF15, which might underlie the previously reported role of stress response in the risk for bipolar disorder in vulnerable populations. PMID: 28291257
    3. A heterozygous de novo mutation (c.830C > T; p.Ser277Leu) in HSPA1L in ulcerative colitis patient. Five additional rare HSPA1L mutations (p.Gly77Ser, p.Leu172del, p.Thr267Ile, p.Ala268Thr, p.Glu558Asp) were found in six other patients. All six rare HSPA1L variant proteins showed decreased chaperone activity in vitro. Moreover, three variants demonstrated dominant negative effects on HSPA1L and HSPA1A protein activity. PMID: 28126021
    4. Polymorphism of HSPA1L gene is associated with the development of esophageal Carcinoma. PMID: 26745065
    5. may be a predictive biomarker for chronic graft-versus-host disease following allogeneic stem cell transplantation PMID: 25680846
    6. HSPA1L (rs2227956) is associated with a decreased risk of idiopathic pulmonary fibrosis in a Mexican population. PMID: 26496868
    7. Infertility in males with normal sperm parameters was not significantly associated with HSPA1L:c.1478C>T gene polymorphism. PMID: 26160076
    8. HSP70-hom polymorphisms modify the association of diethylhexyl phthalates exposure with insulin resistance. PMID: 25044062
    9. In HSPA1L T2437C polymorphisms, there was no significant differences in frequencies of the variant homozygous in patients compared to controls. PMID: 23666708
    10. findings show polymorphisms of HSP70 genes are associated with the development of gastric cancer and duodenal ulcers in a population at high risk for gastric cancer in Costa Rica PMID: 24051039
    11. studied the relationship between blood levels of HSP70 and HSP90 and genotypes of HSP70, GSTT1, and GSTM1 polymorphic variants in individuals chronically exposed to mercury PMID: 23330093
    12. HSP70-hom gene polymorphism may have a role in graft-versus-host disease after hematopoietic stem cell transplantation PMID: 17060867
    13. examined the relationship between the HSP70-hom polymorphism and the clinical characteristics of the malignancy at the time of diagnosis PMID: 17578680
    14. A strong association was found between HSP-70/Hom rs2075800 G and uveitis in patients with sarcoidosis. PMID: 17591867
    15. polymorphisms in HSP70-HOM genes associated with noise-induced hearing loss PMID: 18813331

    顯示更多

    收起更多

  • 蛋白家族：
    Heat shock protein 70 family
  • 組織特異性：
    Expressed in spermatids.
  • 數據庫鏈接：

    HGNC: 5234

    OMIM: 140559

    KEGG: hsa:3305

    STRING: 9606.ENSP00000364805

    UniGene: Hs.690634



主站蜘蛛池模板： 少妇被又大又粗又爽毛片久久黑人| 天天摸天天做天天爽天天弄| 精品无人乱码高清在线观看| 影音先锋久久久久av综合网成人| 日本大尺度吃奶呻吟视频| 国产精品无码专区在线观看| 欧美婷婷丁香五月社区| 亚洲精品网站在线观看你懂的| 在线欧美中文字幕农村电影| www片香蕉内射在线88av8| 无码中文字幕人妻在线一区| 午夜大片男女免费观看爽爽爽尤物| 亚洲五月天综合| 国产在线精品一区二区| 全部露出来毛走秀福利视频| 成 人影片 aⅴ毛片免费观看 | 亚洲免费观看在线视频| 24小时日本在线www免费的| 尤物色综合欧美五月俺也去 | 国产中老年妇女精品| 亚洲国产欧美一区二区好看电影| 图片区小说区亚洲欧美自拍| 东北女人啪啪对白| 国产精品毛片av在线看| 色先锋影音岛国av资源| 久久99国产精品久久| 最近2019中文字幕大全第二页| 国产精品久久无码不卡 | 无码国产激情在线观看| 波多野结衣潮喷视频无码42 | 国产免费久久久久久无码| 青青草国产线观看| 久久一日本综合色鬼综合色| 亚洲天堂男人影院| 国产成人精品午夜福利在线观看 | 奶真大水真多小荡货av| 亚洲人成无码网站在线观看| 国产毛片欧美毛片久久久 | 中文字幕在线观看亚洲日韩| 久久精品人人做人人爽老司机| 久久人人97超碰国产公开|