在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSPA1B Antibody, Biotin conjugated

  • 中文名稱:
    HSPA1B兔多克隆抗體, Biotin偶聯(lián)
  • 貨號:
    CSB-PA28047D0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) HSPA1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    HSPA1B antibody; HSP72 antibody; Heat shock 70 kDa protein 1B antibody; Heat shock 70 kDa protein 2 antibody; HSP70-2 antibody; HSP70.2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Heat shock 70 kDa protein 1B protein (418-641AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1. Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation. Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle. Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling. Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation.; (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell.
  • 亞細胞定位:
    Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
  • 蛋白家族:
    Heat shock protein 70 family
  • 組織特異性:
    HSPA1B is testis-specific.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 5233

    OMIM: 140550

    KEGG: hsa:3303

    UniGene: Hs.274402



主站蜘蛛池模板: 超碰cao已满18进入离开官网| 97色偷偷色噜噜狠狠爱网站| 2022国产成人精品视频人| 亚洲精品无码不卡| 成人麻豆日韩在无码视频| 久久婷婷人人澡人人爽人人喊 | 久久精品免费一区二区三区| 亚洲国产精华液网站w| 男女做爰真人视频直播| 亚洲永久精品ww47| 久久久久99精品成人片牛牛影视| 国产女人天天春夜夜春| 日本免费一区二区三区| 国产乱xxxxx97国语对白| 亚洲aⅴ无码国精品中文字慕| av一区二区三区人妻少妇| 国产美女精品中文网蜜芽宝贝 | 成年美女黄网站色大片免费看 | 久久亚洲熟女cc98cm| 老熟女乱子伦| 国产精品久免费的黄网站| 国产成人免费无码av在线播放| 乌克兰性欧美精品高清| 亚洲精品嫩草研究院久久| 欧美亚洲国产一区二区三区| 国产成人精品日本亚洲77上位| 国产一区二区三区免费高清在线播放| 一色屋精品视频在线观看免费| 日本无码一区二区三区不卡免费| 国产成人av一区二区在线观看| 欧洲熟妇色xxxxx欧美老妇伦| 亚洲精品日本一区二区三区 | 久久久综综合色一本伊人| 性色欲网站人妻丰满中文久久不卡| 99蜜桃在线观看免费视频网站| 玩弄少妇的肉体k8经典| 亚洲.日韩.欧美另类| 九九精品99久久久香蕉| 成人综合网站| 在线毛片片免费观看| 人人妻人人爽人人添夜夜欢视频|