在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

HSD17B8 Antibody

  • 中文名稱:
    HSD17B8兔多克隆抗體
  • 貨號:
    CSB-PA010779GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    HSD17B8
  • 別名:
    17 beta HSD 8 antibody; 17 beta hydroxysteroid dehydrogenase 8 antibody; 17-beta-HSD 8 antibody; 17-beta-hydroxysteroid dehydrogenase 8 antibody; 17-beta-hydroxysteroid dehydrogenase VIII antibody; 3-oxoacyl-[acyl-carrier-protein] reductase antibody; 3-oxoacyl-acyl-carrier protein reductase, E. coli, homolog of antibody; Beta ketoacyl [acyl carrier protein] reductase like antibody; D6S2245E antibody; DHB8_HUMAN antibody; dJ1033B10.9 antibody; Estradiol 17 beta dehydrogenase 8 antibody; Estradiol 17-beta-dehydrogenase 8 antibody; Estrogen 17 oxidoreductase antibody; FABG antibody; FabG, E. coli, homolog of antibody; FabG-like antibody; FABGL antibody; H2 KE6 antibody; H2-KE6 antibody; HKE6 antibody; HSD17B8 antibody; Hydroxysteroid (17 beta) dehydrogenase 8 antibody; Ke-6 antibody; KE6 antibody; KE6, mouse homolog of antibody; Protein Ke6 antibody; Really interesting new gene 2 protein antibody; RING2 antibody; SDR30C1 antibody; Short chain dehydrogenase/reductase family 30C member 1 antibody; Testosterone 17 beta dehydrogenase 8 antibody; Testosterone 17-beta-dehydrogenase 8 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human HSD17B8
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol.
  • 基因功能參考文獻:
    1. The results indicate that aromatase, 17beta-HSD type 7 and 17beta-HSD type 12, but not 17beta-HSD type 1, are commonly expressed in human breast cancer. PMID: 16930994
    2. transcription in liver is regulated by C/EBPbeta PMID: 17583490
    3. Expression of the human Ke 6 gene, 17beta-hydroxysteroid dehydrogenase type 8, in E. coli and the substrate specificity of the expressed protein were examined. The tissue distribution of mRNA expression of the human Ke 6 gene was also studied. PMID: 17978863
    4. ERalpha is involved in the transcriptional regulation of HSD17B8 gene in response to E2 through its interaction with C/EBPbeta. PMID: 18852215
    5. Hs17beta-HSD8 and HsCBR4 show a strong genetic interaction in vivo in yeast, where, only if they are expressed together, they rescue the respiratory deficiency and restore the lipoic acid content of oar1Delta cells. PMID: 19571038
    6. HSD17B8 mRNA is expressed in human skin, at lower levels in face vs arm or hip. HSD17B8 levels are not altered by topical 17-beta-estradiol treatment. PMID: 18794456

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    Short-chain dehydrogenases/reductases (SDR) family
  • 組織特異性:
    Widely expressed, particularly abundant in prostate, placenta and kidney. Expressed at protein level in various tissues like brain, cerebellum, heart, lung, kidney, ovary, testis, adrenals and prostate.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 3554

    OMIM: 601417

    KEGG: hsa:7923

    STRING: 9606.ENSP00000363794

    UniGene: Hs.415058



主站蜘蛛池模板: 99久久久无码国产精品免费砚床 | 人妻在线无码一区二区三区| 99久久亚洲精品无码毛片| 成av免费大片黄在线观看| 中文字幕一二三区波多野结衣| 中美日韩毛片免费播放| 无码人妻h动漫| 日本免费一区二区三区四区五六区| 粉嫩粉嫩的18在线观看| 人人澡人人澡人人看添av| 一区二区传媒有限公司| 国产精品天干天干综合网| 亚洲欧美成人a∨观看| 亚洲成av人片高潮喷水| 欧美浓毛大泬视频| 51视频国产精品一区二区| 国产成人精品一区二区视频| 亚洲综合日韩av无码毛片| 国产偷亚洲偷欧美偷精品| 国产成人综合亚洲色就色| 国产成人欧美日韩在线电影| 浴室人妻的情欲hd三级国产| 国产精品日本一区二区在线播放| 婷婷丁香五月六月综合激情啪| 高清国产av一区二区三区| 日日碰狠狠躁久久躁婷婷| www国产亚洲精品久久网站| 国产日韩亚洲大尺度高清 | 一边吃奶一边做动态图| 一区二区三区国产亚洲网站| 免费无码成人av电影在线播放| 国产成人精选在线观看不卡| 在线视频网站www色| 亚洲国产高清在线一区二区三区| 最新国产精品久久精品| 熟女人妇 成熟妇女系列视频| www国产内插视频| 97精品免费公开在线视频| 日本成本人片免费网站| 男女性杂交内射妇女bbwxz| 国产成人av区一区二区三|